Dynamics of a growth factors serum level in therapy of myocardial infarction with mesenchymalstem cells in an experiment

A S Golovkin; E A Velikanova; V G Matveeva; E A Saveleva; A V Eremeev; Yu I Sheina; A V Svetlakov

doi:10.23868/gc121658

Genes & Cells ›› 2011, Vol. 6 ›› Issue (2) : 43 -47. DOI: 10.23868/gc121658

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Dynamics of a growth factors serum level in therapy of myocardial infarction with mesenchymalstem cells in an experiment

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Kemerovo Cardiology Center, Siberian branch of the RAMS

Krasnoyarsk Center for Reproductive MedicineKrasnoyarsk State Medical InstituteInstitute of Biophysics, Siberian branch of the RAS, Krasnoyarsk

Krasnoyarsk Center for Reproductive MedicineKrasnoyarsk State Medical Institute

Kemerovo Cardiology Center, Siberian branch of the RAMS

Krasnoyarsk Center for Reproductive MedicineKrasnoyarsk State Medical InstituteInstitute of Biophysics, Siberian branch of the RAS, Krasnoyarsk

Krasnoyarsk Center for Reproductive MedicineKrasnoyarsk State Medical Institute

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Abstract

The aim of the work was to assess TGF в, VEGF-C andGM-CSF concentrations in the serum of rats after postinfarctintramyocardial injection of mesenchymal stem cells.Myocardial infarction was simulated by the criodestructionof the left ventricular anterior wall. Mesenchymal stemcells were derived from rat bone marrow and injected intomyocardium 21 days after the crioinjury. The levels of TGF в,VEGF-C and GM-CSF were measured at 3, 7 and 14 days. Thesynthetic activity of the transplanted cells to these growthfactors in vitro was also measured. It was shown that theadministration of mesenchymal cells leads to an increasedlevel of TGF в in the peripheral blood. The maximum TGF вconcentration was observed on Day 7 after transplantation.Despite the intensive synthesis of VEGF-C and GM-CSF bymesenchymal cells in vitro, they do not demonstrate asignificant effect on the level of the studied growth factors inthe peripheral blood.

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A S Golovkin, E A Velikanova, V G Matveeva, E A Saveleva, A V Eremeev, Yu I Sheina, A V Svetlakov. Dynamics of a growth factors serum level in therapy of myocardial infarction with mesenchymalstem cells in an experiment. Genes & Cells, 2011, 6(2): 43-47 DOI:10.23868/gc121658

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