TIME COURSE OF LL-37 ANTIBACTERIAL PEPTIDE IN PATIENTS WITH VULGAR ACNEDURING PHOTOTHERAPY

A V Makhmudov , O Yu Olisova , A S Borovaya , A V Makhmudov , O Yu Olisova , A S Borovaya

Russian Journal of Skin and Venereal Diseases ›› 2012, Vol. 15 ›› Issue (4) : 51 -52.

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Russian Journal of Skin and Venereal Diseases ›› 2012, Vol. 15 ›› Issue (4) : 51 -52. DOI: 10.17816/dv42742
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TIME COURSE OF LL-37 ANTIBACTERIAL PEPTIDE IN PATIENTS WITH VULGAR ACNEDURING PHOTOTHERAPY

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Abstract

Catelicidine (antibacterial peptide) in the LL-37 form is characterized by anti-infl ammatory,immunoregulatory, and bactericidal effects towards P. acnes. Serum levels of this peptide were measured in30 patients with acne of different severity (I, II, and III degree) by EIA before and after highly intense bluelight (405-420 nm) phototherapy. The level of LL-37 peptide directly correlated with the disease severityand normalized after phototherapy.

Keywords

LL-37 / acne / antibacterial peptides / catelicidine / LL-37

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A V Makhmudov, O Yu Olisova, A S Borovaya, A V Makhmudov, O Yu Olisova, A S Borovaya. TIME COURSE OF LL-37 ANTIBACTERIAL PEPTIDE IN PATIENTS WITH VULGAR ACNEDURING PHOTOTHERAPY. Russian Journal of Skin and Venereal Diseases, 2012, 15(4): 51-52 DOI:10.17816/dv42742

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