Changes in the phenotype and functional metabolic activity of immunocompetent blood cells in infants with Epstein-Barr virus infection

Abstract

Sixty-eight patients aged 1-3 years, with infectious mononucleosis caused by Epstein-Barr virus infection, were followed up in the acute period of the disease. Cellular and humoral immunological parameters, the lymphocyte activity of NAD(P)-dependent dehydrogenases, the phagocytic activity, spontaneous and induced chemiluminescence of peripheral blood neutrophils were studied. Changes were found in the immunophenotypic spectrum and enzyme status of peripheral blood lymphocytes. Impairments were detected in the phagocytic activity and chemiluminescent response of neutrophils.

Keywords

Epstein-Barr virus infection / immunity / enzymes / chemiluminescence

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