The clinical and epidemiological characteristics of parenteral hepatitides and opportunistic infections in women with obstetric and gynecological diseases

S M Kazaryan; E D Danilenko; E E Musina; S G Mardanly; T R Bakhshinyan; Arpik Ashotovna Asratyan; S M Kazaryan; E D Danilenko; E E Musina; S G Mardanly; T R Bakhshinyan; A A Asratyan

doi:10.17816/EID40551

Epidemiology and Infectious Diseases ›› 2011, Vol. 16 ›› Issue (2) : 23 -28. DOI: 10.17816/EID40551

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The clinical and epidemiological characteristics of parenteral hepatitides and opportunistic infections in women with obstetric and gynecological diseases

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N. F. Gamaleya Research Institute of Epidemiology and Microbiology, Russian Academy of Medical Sciences, Moscow

Institute for Postgraduate Training of Physicians, Ministry of Health and Social Development of the Chuvash Republic

L. A. Tarasevich State Research Institute for Standardization and Control of Medical Biological Preparations, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare, Moscow

OOO"Ecolab", Moscow Region

N. F. Gamaleya Research Institute of Epidemiology and Microbiology, Russian Academy of Medical Sciences, Moscow

Institute for Postgraduate Training of Physicians, Ministry of Health and Social Development of the Chuvash Republic

L. A. Tarasevich State Research Institute for Standardization and Control of Medical Biological Preparations, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare, Moscow

OOO"Ecolab", Moscow Region

N. F. Gamaleya Research Institute of Epidemiology and Microbiology, Russian Academy of Medical Sciences, Moscow

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Abstract

One hundred and twenty women with obstetric and gynecological diseases, such as women with infertility (Group 1), nonpregnant ones with a history of miscarriage (Group 2), and pregnant ones with a history of habitual miscarriage (Group 3) were examined. Comparison groups comprised 150 female blood donors and 200 pregnant women with physiological pregnancy (Cheboksary, Chuvash Republic).Enzyme immunoassay was used to determine IgM and IgG HBsAg, anti-HBs, anti-HBc, and anti-HCV; as well as IgM and IgG antibodies against cytomegalovirus (CMV) infection, herpes simplex virus (HSV) infection, and toxoplasmosis; polymerase chain reaction was employed to identify hepatitis B (HB) virus (HBV) DNA and hepatitis C (HC) virus (HCV) RNA.No substantial differences were found in the detection of markers of HB in women with a history of obstetric and gynecological diseases (HOGD) (30.8% of cases) and in the comparison groups (34 and 31%); markers of HC were more frequently seen in women with HOGD (5.8%): 10% (50% RNA+) in Group 1, 5% (all RNA+) in Group 2, and 2 and 3% in the control groups, respectively.In the HOGD groups A, there was a large proportion of patients having IgM antibodies against CMV infection (2.5 to 5%), HSV (5%), and T. gondi (10-15%).There was a high percentage of subjects with markers of HC among women with obstetric and gynecological diseases (5.8 and 2% in the blood donors). A combination of markers of infections, such as HBV+HSV, HBV+CMV, HBV+HSV+CMV, HCV+HSV, and HCV+HSV+CMV, was found in a considerable proportion of subjects with HOGD. Among the clinical manifestations, there was a preponderance of infertility, a history of miscarriage, threatening miscarriage during current pregnancy, fetal growth retardation, and placentitis. No clinical manifestations of the study infections were observed in all the examinees so serological assays rank first to diagnose these infections.

Keywords

hepatitides B and C / cytomegalovirus infection / herpes simplex virus-induced infection / toxoplasmosis / women with obstetric and gynecological diseases / pregnant women

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S M Kazaryan, E D Danilenko, E E Musina, S G Mardanly, T R Bakhshinyan, Arpik Ashotovna Asratyan, S M Kazaryan, E D Danilenko, E E Musina, S G Mardanly, T R Bakhshinyan, A A Asratyan. The clinical and epidemiological characteristics of parenteral hepatitides and opportunistic infections in women with obstetric and gynecological diseases. Epidemiology and Infectious Diseases, 2011, 16(2): 23-28 DOI:10.17816/EID40551

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