Role of phosphoinositide metabolism in multiple sclerosis pathogenesis
М. М. Gerasimova , Т. V. Menshikova
Neurology Bulletin ›› 1998, Vol. XXX ›› Issue (3-4) : 27 -29.
Role of phosphoinositide metabolism in multiple sclerosis pathogenesis
Phosphoinositides in lymphocytes and machrophages in 20 patients with multiple sclerosis have been studied with the help of highly effective liquid and thin-layer chromatography. In all patients phosphoinositide metabolism inpairment was revealed, which can be caused both by impairment of phosphoinositide response of immunocompetent cells, and by connecting myelin with consequent demyelinization. The revealed fact may serve one of criteria of demyelinizathion process activity, and also evidences the certain role of the revealed impairment in multiple sclerosis pathogenesis.
Neurological archive of Bekhterev
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Gerasimova М.М., Menshikova Т.V.
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