In women of reproductive period all variants of cerebral circulation impairment can be seen, but more often initial manifestations of cerebral circulation impairment and transient manifestations have place. It was found a direct relationship between estradiol concentration decrease, sexual glands functions’ disturbance and increase of lipid contents in blood and lipoprotein atherogenic fractions.

There was performed investigation of rhelogic properties, of coagulation and anticoagulation blood systems in 88 patients of senile age with ischemic insult in the carotid system. It was determined that for elderly patients highly expressed tendencies for hyperaggregation and suppression of their own fibrinolytic blood activity are characteristic features. Initially increased level of aggregation and hypercoagulation, combined with presence in blood fibrin-monomer complexes were accompanied by progressing DIC syndrome, and as a rule, were associated with steady neurology deficiency and high incidence of mortality. Possible correction ways were considered for hemostasis system disorders in elderly patients.

Brain hemodynamics was studied in vertebra-basilar region in patients with vibration disease, resulting from local vibration. High percentage of clinical and roentgenologic manifestations of cervical octeochondrosis was revealed, as well as incidence increase of cephalgia syndrome while vibration disease progressing. Analysis of rheographic curves (deviation by E.Enin) and transcranial dopplerosonograms showed cerebral circulation dificiency in vertebrabasilar region. The highest level of hemodynamic disorders was marked in vertebral arteries. It is not excluded, that one of the factors, enfluencing hemodynamics disorders, is pathology of the vertebral column.

On the basis of analyzing clinical data and data from past history of patients with postinsult neurologic dificiency, a conclusion has been made by correlation analysis and determination of connection closeness between separate clinical signs. The conclusion tells about nonhomogeneity of motor disorders genesis in patients with hemi-sphere insult, foundation of which different chains of pathophysiology process make up.

It was performed complex ultrasound investigation of 50 patients with hemorragic fever at different stages of disease. Analysis of dopplerographic parameters showed, that in acute stage of disease the following patterns of changed cerebral blood flow can be determined: poor cerebral perfusion, stenosis and venous discirculation. In reconvalescent patients in comparison with the control group reliable deviations retained, presented mostly by autoregulatory disorders. For prognostic risk development evaluation of late neurologic complications in patients, having had hemorrhagic fever, cerebro-renal index was suggested.

Study of biorhythmostimulation efficiency in complex treatment of patients with initial forms of brain blood supply insufficiency was carried out. The obtained results are indicative of high efficiency of the given method of psychoemotional condition of patients. True reliable normalisation of arterial pressure, brain vascular tension, vegetative nervous system, cerebral cortex electrical activity took place. Biorhythmostimulatuion is a highly effective and pathogenically substantiated method of psychoemotional condition correction and can be widely used with medical purposes for patients with initial forms of brain blood supply insufficiency.

Results of epidemiologic reseach of environmental risс factors for multiple sclerosis among Moscow population are given. It was shown, that provoking factors for development or exacerbation this pathology are infections and stress situations. Diet habits, chronic bacterial infections of respiratory tract are significant too. The obtained results can be used in development of a certain diet and preventive measures.

Phosphoinositides in lymphocytes and machrophages in 20 patients with multiple sclerosis have been studied with the help of highly effective liquid and thin-layer chromatography. In all patients phosphoinositide metabolism inpairment was revealed, which can be caused both by impairment of phosphoinositide response of immunocompetent cells, and by connecting myelin with consequent demyelinization. The revealed fact may serve one of criteria of demyelinizathion process activity, and also evidences the certain role of the revealed impairment in multiple sclerosis pathogenesis.

Reliable dependence between factors of medicobiological, psychoemotional and social disadaptation in patients with neurologic manifestations of osteochondrosis of spine lumbar department was revealed. A model of correlation of different personal disadaptation factors of disease progressing has been developed. The obtained data can be used when planning and carrying out rehabilitation measures.

Hemodynamics of children with natal trauma of spinal cord’s cervical department was studied. It was determined, that among numerous manifestations of late complications of natal cervical traumas amyotrophy syndrome of shoulder girdle is widely spread, in which in 65% of cases hemodynamics insufficiency is determined in the carotid region, and in 37% - in vertebro-basilar region. Functional tests allowed to determine occult blood flow insufficiency in vertebro-basilar region in 80% of cases, thus confirming presence of chronic circulatory insufficiency in the system of vertebral arteries in patients with amyotrophy syndrome of shoulder girdle.

In 10 able-bodied individuals and 8 patients with the cerebral palsy reciprocal and non-reciprocal inhibitions of soleus motoneurones were investigated by means of the H-reflex conditioned by electrical stimulation of the tibialis and gastrocnemius medialis nerves, respectively. In normal individuals short- and long-latency periods of both reciprocal and non-reciprocal inhibitions were found. The cerebral palsy patients showed the increased inhibitory influence with more enhanced short-latency components of inhibition. A possible role of inhibitory systems in limitation of patologically activated antigravitant soleus motoneurones was discussed.

Peculiarities of infringement of the vegetative status in children, having had concussion of a head brain are revealed. Infringements of vegetative systems’ activity was displayed by an oppression of eigotrop’s link, causing unsufficient vegetative reaction and inadequate vegetative maintenance of activity. Interrelation of character of vegetative reaction with terms of remote period was shown. Influence of age of the children, character of perynatal anamnes, degree of clinical indemnification were revealed.

In experiments in vitro and in vivo competitive relationships of diphtheria toxin and nerves growth factor were shown: in organotypical culture (300 sensor ganglions) and in model of experimental diphtheria neuropathy in 66 white rats. There were given evidences of protective action of nerves growth factor, inhibiting the toxic effect of diphtheria toxin. Contents of free toxin and specific immune comlexes was studied in 25 children with diphtheria polyneuropathy. Favourable outcome of disease was observed in children with high presence of nerves growth factor in blood serum, thus giving new approach in treatment of nervous system diseases.

The problem of rehabilitation of stroke patients is being actively developed in modern medicine. According to the World Health Organization, 100-300 cases of stroke occur annually in developed countries for every 100 thousand people. In Russia, these numbers are 250-320 among the urban population (according to the registers of cerebral stroke in Moscow and Novosibirsk) and 170 among the rural population (according to the Stavropol Territory).

Neurofibromatosis is a hereditary disease characterized by the presence of many tumors located in the skin, along the peripheral nerves, in the central nervous system, skin pigmentation with bone anomalies, and damage to internal organs.

Vascular diseases of the brain are widespread and largely determine such indicators of public health as life expectancy, morbidity, and mortality. In the overall structure of mortality, cerebral strokes rank second after heart disease.

Paroxysmal states are interpreted ambiguously by different authors. A different assessment of their character creates additional difficulties for a practitioner, primarily a pediatric neuropathologist. One of the most difficult tasks that a specialist has to solve in everyday work is the differentiation of epilepsy and conditions of a non-epileptic nature that are similar in some features.

According to WHO statistics, from 40 to 80% of the world's adult population suffer from clinical syndromes of osteochondrosis of the spine. As one of the most common causes of temporary disability, they lead to significant economic losses.

The key mechanism of the pathogenesis of multiple sclerosis (MS) is demyelination and the associated impairment of axonal impulse conduction. This disease is genetically determined to a certain extent.

Since the discovery of the functional asymmetry of the cerebral hemispheres, interhemispheric lateralization and intrahemispheric organization of the brain have been a leading problem in clinical neurology.

The outstanding scientist V.M. Bekhterev is known as a pioneer in a number of fields of natural science and medicine - neurology and psychiatry, physiology, biology, psychology and pedagogy.

The scientific and social activities of the talented neuropathologist Alexander Alexandrovich Kornilov have not received due reflection in the neurological literature, monographs and articles on the history of Russian neurology.