ULTRASTRUCTURAL CHANGES IN AXON-DENDRITIC SYNAPSES OF CA1 OF HIPPOCAMPUS UNDER 96-HOUR PARADOXIAL SLEEP DEPRIVATION

Abstract

With the application of electron microscope technique the morphology of axon-dendritic synapses in area CA1 of rat hippocampus under 96-hour paradoxical sleep deprivation has been studied. On the basis of quantitative and qualitative-morphometric analysis it has been stated that the ultrastructure of the components of most symmetrical and asymmetrical axon-dendritic synapses were deeply affected in response to the 96-hour paradoxical sleep deprivation. The revealed ultrastructural alterations in axon-dendritic synapses of CA1 area can be considered as synaptic level of disturbances of neurophysiological mechanisms of learning and memory processes.

Keywords

deprivation of paradoxical sleep / CA1 area of hippocampus / synapse / dystrophic changes / learning and memory

References

[1] 1. Лакин Г.Ф. Биометрия. - М., 1990.

[2] 2. Семченко В.В., Степанов С.С., Боголепов Н.Н. Пластичность синапсов головного мозга. - Омск, 2008.

[3] 3. Brankaиk J., Platta B., Riedel G. // Progr. Neuro-Psychopharmacol. Biol. Psychiat. -2009. - Vol . 33. - P. 806-812.

[4] 4. Jouvet M. // Progr. Brain Res. - 1965. - Vol. 18. - P. 257-258.

[5] 5. Kasai H., Fukuda M., Watanabe S. // Tren. Neurosci. - 2010. - Vol. 33. - P. 121-129.

[6] 6. Kim E.Y., Mahmoud G.S., Grover L.M. // Neurosci. Let. - 2005. - Vol. 388, № 3. -P. 163-167.

[7] 7. Morgado-Bernal I. // Neuroscience. - 2011. - Vol. 176. - P. 12-19.

[8] 8. Penzes P., Jones K.A. Tren. Neurosci. - 2008. - Vol. 31. - P. 419-427.

[9] 9. Ruskin D.N., LaHostea G.J. // Behav. Brain Res. - 2008. - Vol. 191. - P. 67-71.

[10] 10. Sweatt J.D. Mechanisms of Memory. - N. Y., Elsevier LTD, 2010.

[11] 11. Walker M.P. // Progr. Brain Res. - 2010. - Vol.185. - P. 49-68.

[12] 12. Yang R.H., Hu S.J., Wang Y. et al. // Brain Res. - 2008. - Vol.1230. - P. 224-232.

RIGHTS & PERMISSIONS

Abushov B.M.