TITRE OF ANTIBODIES TO THE ACETYLCHOLINE RECEPTOR IN PATIENTS WITH MYASTHENIA

Abstract

There was studied titre of antibodies to the acetylcholine receptor in patients with myasthenia serum at pre-surgery stage. In patients with myasthenia with hyperplasia of thymus gland the average level of antibodiacetylcholine receptor exceeded 4 times the normal values and in patients with thymoma- 8 times. Level of antibodies to AChR did not correlate with the severity of myasthenia and myasthenia, combined with thymoma but tended to increase with the deterioration in specific cases. With a history of the disease more than a year there is a sharp increase in antibody levels in patients' serum, which leads to the progression of the disease.

Keywords

thymus / myasthenia gravis / antibody to the acetylcholine receptor (AChR)

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RIGHTS & PERMISSIONS

Nikishov V.N., Bogdanov E.I., Sigal E.I., Sigal A.M.