POLYMORPHISM OF INTERLEUKIN GENE-1 (IL-1β) IN PATIENTS WITH MULTIPLE SCLEROSIS

Abstract

There were examined 60 patients with remitting type of multiple sclerosis. Genotyping had been performed with the help of PCR by a polymorphic variant +3953 А1/А2 gene IL-1в. It was found that polymorphism IL-1в +3953 A1/A2 is not the leading factor in a susceptibility to multiple sclerosis and does not define the disease phenotype. At the same time presence of some or other allele can contribute into misbalance between proinflammatory and anti-inflammatory cytokines.

Keywords

genotype / allele / immune answer / multiple sclerosis

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RIGHTS & PERMISSIONS

Аlifirova V.М., Оrlova Y.Y., Тitova М.А., Cherdyntseva N.V.