REACTIVITY MECHANISMS OF AIRWAYSMOOTH MUSCLE TISSUE IN EXPERIMENTALBRONCHIAL SPASM

Abstract

This investigation was aimed at the complex evaluation of the reactivity mechanisms of bronchial smooth muscle tissue (SMT)in experimental bronchial spasm. Morphometric, cytospectrophotometricand electron microscopical analysis demonstratedthe presence of three types of smooth muscle cells (SMC) withinthe bronchial SMT (small, medium, large), that differed in theirlinear and metabolic parameters. The findings of this study indicatethat under the conditions of experimental bronchial spasmdevelopment, the ratios of SMC in bronchial SMT are changedwith the increase in proportion of small SMC and the eliminationof large SMC. In the dynamics of experimental bronchial spasmdevelopment, the activation of cytoplasmic synthesis as well as of DNA synthesis was detected mainly in group of small SMC.The reactive-dystrophic changes were marked at the subcellularlevel, that were most often identified in large SMC resulting in their elimination from population in the dynamics of an experiment.The data obtained suggest that one of the important mechanismsof airway SMT adaptation to the bronchial spasm developmentis a dynamic reorganization of SMC population.

Keywords

smooth muscle tissue / smooth muscle cells / bronchi

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