STRUCTURAL CHANGES IN RAT INTESTINALWALL DURING STARVATION

Abstract

The aim of this study was to determine the effect of starvationon all the tunics of duodenum and rectum wall. The animals were20 outbred albino rats; the control group comprised 4 animals.The animals were starved while the drinking regime remainedunchanged. Material was obtained at days 3 and 6 of starvationand was studied using electron microscopy. The changes weredetected in the structure of mucosa, submucosa, tunica muscularisand serosa. These structural changes were of similar naturein all the tunics and differed only by the degree of their severity.The most pronounced changes were observed in all the epithelialcell types (absorbing, goblet and endocrine) in both parts of the intestine. These included cell flattening, microvilli reduction and deformation, mucus production disturbances, destructive changesin the mitochondria (swelling, cristae reduction, vacuoles and myelin-like structures formation, disruption of both mitochondrialmembranes).

Keywords

intestine / ultrastructure / starvation / rat

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