HISTOCHEMICAL STUDY OF MYOCARDIUMSTRUCTURE IN HEART CONTUSION
V P Novoselov , S V Savchenko , D A Koshlyak , M V Voronkovskaya , V P Novosyolov , S V Savchenko , D A Koshlyak , M V Voronkovskaya
Morphology ›› 2009, Vol. 136 ›› Issue (6) : 53 -56.
HISTOCHEMICAL STUDY OF MYOCARDIUMSTRUCTURE IN HEART CONTUSION
The experimental modeling of heart contusion which was accompanied by ventricular fibrillation development was performedin Wistar rats, with the electrocardiographic study and subsequent histological and histochemical examination of the myocardium samples. Following heart contusion, acute circulatorydisturbances, muscle fiber fragmentation, cardiomyocyteovercontraction or relaxation were detected in the myocardium.Also, the increase of total and intracellular calcium ion contentin the myocardium was demonstrated. It is suggested that the mechanism of ventricular fibrillation development after heartcontusion is associated with the increase of calcium concentrationin both the cardiomyocytes and intercellular spaces leadingto uncoordinated cardiac contractions.
heart / myocardium / total Ca2+ / intracellular Ca2+ / contusion
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