MORPHO-FUNCTIONAL CHANGES OF FROURINARY BLADDER RECEPTORS UNDERTHE INFLUENCE OF BARBITURATES
V G Lukashin , V V Vshivtseva , V G Lukashin , V V Vshyvtseva
Morphology ›› 2009, Vol. 136 ›› Issue (6) : 48 -52.
MORPHO-FUNCTIONAL CHANGES OF FROURINARY BLADDER RECEPTORS UNDERTHE INFLUENCE OF BARBITURATES
The effect of hexenal and nembutal on the tissue bushy receptorswas studied the living isolated frog urinary bladder usingmethylene blue staining. These drugs were shown to inducethe changes in the receptor pulse activity which included threephases: an initial sharp increase, an abrupt decline and a low protracted plateau. Reactions to hexenal and nembutal, whilepossessing some common features, had their own peculiarities.Synchronously, the dynamics of methylene blue staining of the receptor elements was registered for the control of the intensityof oxidation-reduction processes in the receptor neuroplasm, that is for redox-system dynamics. It was found that the phasesof this dynamics coincided in many respects with the phases of the receptor electric activity changes. No ultrastructural changesassociated with the putative damaging effect of barbiturates on the receptors were recorded (during the exposure of 1-30 min).The most significant characteristic was an accumulation glycogengranules in the neuroplasm of the receptor elements, suggestingthe prevalence of energy substrate deposition over its expenditure. Depression of the receptor pulse activity supportsthe assumption that barbiturates, besides their soporific and narcoticactions, apparently possess some anesthetic property.
bushy receptors / urinary bladder / barbiturates / anesthesia / frog
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