MORPHO-FUNCTIONAL IMPLICATIONSOF BETA-AMYLOID APPLICATION ONTOTHE GOLDFISH MAUTHNER CELLS

N A Kokanova; G Z Mikhaylova; R Sh Shtanchaev; N R Tiras; E N Bezgina; D A Moshkov; N A Kokanova; G Z Mikhailova; R Sh Shtanchayev; N R Tiras; Ye N Bezgina; D A Moshkov

doi:10.17816/morph.399201

Morphology ›› 2009, Vol. 136 ›› Issue (6) : 43 -47. DOI: 10.17816/morph.399201

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MORPHO-FUNCTIONAL IMPLICATIONSOF BETA-AMYLOID APPLICATION ONTOTHE GOLDFISH MAUTHNER CELLS

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Abstract

The influence of aggregated beta-amyloid peptide fragment25-35 application on three-dimensional structure and volumeof Mauthner cells (MCs), as determined by reconstruction fromserial histological sections, and on goldfish motor asymmetry was studied. It was shown that in intact and control goldfish motorasymmetry was stable and strongly correlated with structuralasymmetry of neurons. But under the influence of beta-amyloid, motor asymmetry appeared to be strongly changed or inverted, did not correlate with structural asymmetry and frequently evenwas opposite to it. This resulted from strong dystrophy or, on the contrary, hypertrophy of individual neurons and their separatedendrites with the change in the proportions between them. It is suggested that injurious effect of beta-amyloid peptide on MCs structure, discordant with (irregular) fish behavior, could be the result of mechanical deformation, induced by ribbon-like fibrilsof amyloid peptide. These findings collectively suggest that MCs are the adequate object for the study of the structural aspects of amyloidosis.

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Mauthner cells / structure / function / beta-amyloid 25-35

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N A Kokanova,G Z Mikhaylova,R Sh Shtanchaev,N R Tiras,E N Bezgina,D A Moshkov,N A Kokanova,G Z Mikhailova,R Sh Shtanchayev,N R Tiras,Ye N Bezgina,D A Moshkov. MORPHO-FUNCTIONAL IMPLICATIONSOF BETA-AMYLOID APPLICATION ONTOTHE GOLDFISH MAUTHNER CELLS. Morphology, 2009, 136(6): 43-47 DOI:10.17816/morph.399201

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