CHANGES IN NEURONS AND GLIOCYTESOF RAT MESOACCUMBOCINGULATE SYSTEMFOLLOWING PERINATAL MORPHINEADMINISTRATION

A V Droblenkov; N R Karelina; P D Shabanov; A V Droblenkov; N R Karelina; P D Shabanov

doi:10.17816/morph.399196

Morphology ›› 2009, Vol. 136 ›› Issue (6) : 35 -37. DOI: 10.17816/morph.399196

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CHANGES IN NEURONS AND GLIOCYTESOF RAT MESOACCUMBOCINGULATE SYSTEMFOLLOWING PERINATAL MORPHINEADMINISTRATION

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Abstract

To study the changes of neuron and gliocyte numbers and somemorphometric parameters in mesoaccumbocingulate (MAC)dopaminergic system of rats after pre- and postnatal opiate treatment, 0.1 mg dose of 1% morphine hydrochloride solution was injected into the fetal amnion of Wistar female rats (n=4) at Day 17 post fertilization and intraperitoneally into newborn rats (n=4)at postnatal Day 4. Perinatal influence of morphine on MACsystemin rats resulted in the chromophilic degeneration, swellingand death of some part of neurons, decrease in the volumeof the other (slightly injured) neurons. Neuronal injury was morepronounced after prenatal morphine treatment and was accompaniedby the increase in both microgliocyte cell number and phagocytic activity. Morphine administration induced no changesin the satellite macrogliocyte number and in the average distancebetween these cells and the bodies of slightly injured neurons.

Keywords

neurons / gliocytes / dopaminergic system / perinatal morphine administration

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A V Droblenkov, N R Karelina, P D Shabanov, A V Droblenkov, N R Karelina, P D Shabanov. CHANGES IN NEURONS AND GLIOCYTESOF RAT MESOACCUMBOCINGULATE SYSTEMFOLLOWING PERINATAL MORPHINEADMINISTRATION. Morphology, 2009, 136(6): 35-37 DOI:10.17816/morph.399196