CHANGES IN NEURONS AND GLIOCYTESOF RAT MESOACCUMBOCINGULATE SYSTEMFOLLOWING PERINATAL MORPHINEADMINISTRATION

A V Droblenkov; N R Karelina; P D Shabanov; A V Droblenkov; N R Karelina; P D Shabanov

doi:10.17816/morph.399196

Morphology ›› 2009, Vol. 136 ›› Issue (6) : 35 -37. DOI: 10.17816/morph.399196

Articles

other

CHANGES IN NEURONS AND GLIOCYTESOF RAT MESOACCUMBOCINGULATE SYSTEMFOLLOWING PERINATAL MORPHINEADMINISTRATION

Author information +

History +

PDF

Abstract

To study the changes of neuron and gliocyte numbers and somemorphometric parameters in mesoaccumbocingulate (MAC)dopaminergic system of rats after pre- and postnatal opiate treatment, 0.1 mg dose of 1% morphine hydrochloride solution was injected into the fetal amnion of Wistar female rats (n=4) at Day 17 post fertilization and intraperitoneally into newborn rats (n=4)at postnatal Day 4. Perinatal influence of morphine on MACsystemin rats resulted in the chromophilic degeneration, swellingand death of some part of neurons, decrease in the volumeof the other (slightly injured) neurons. Neuronal injury was morepronounced after prenatal morphine treatment and was accompaniedby the increase in both microgliocyte cell number and phagocytic activity. Morphine administration induced no changesin the satellite macrogliocyte number and in the average distancebetween these cells and the bodies of slightly injured neurons.

Keywords

neurons / gliocytes / dopaminergic system / perinatal morphine administration

Cite this article

Download citation ▾

A V Droblenkov, N R Karelina, P D Shabanov, A V Droblenkov, N R Karelina, P D Shabanov. CHANGES IN NEURONS AND GLIOCYTESOF RAT MESOACCUMBOCINGULATE SYSTEMFOLLOWING PERINATAL MORPHINEADMINISTRATION. Morphology, 2009, 136(6): 35-37 DOI:10.17816/morph.399196

登录浏览全文

4963

注册一个新账户忘记密码

References

Publishing order | Descend order by publishing year | Descend order by cited within

[1]	Бережной Р.В., Смусин Я.С. и Томилин В.В. Руководство по судебно-медицинской экспертизе отравлений. М., Медицина, 1980.

[2]	Богомолов Д.В., Пиголкин Ю.И. и Должанский О.В. Морфометрическое исследование нейроглиальных комплексов головного мозга при судебно-медицинской диагностике наркоманий. Суд.-мед. эксперт., 2001, т. 44, № 4, с. 18-19.

[3]	Должанский О.В. Судебно-медицинская оценка морфологических изменений головного мозга при хронических опийных наркоманиях: Автореф. дис. … канд. мед. наук. М., 2001.

[4]	Bjorklund A. and Lindvall O. Dopamine-containing systems in the CNS. In: Handbook of Neuroanatomy. V. 2. Classical neurotransmitters in the CNS. Part 1. Amsterdam, New York, Oxford, Elsevier Science Publishers, 1984, р. 55-122.

[5]	Kanapp P.E. and Heuser K.F. mu-Opioid receptor activation reduces DNA synthesis in immature olygodendrocytes. Brain Res., 1996, v. 16, № 1-2, p. 341-345.

[6]	Sonetti D., Ottaviani E. and Stefano G.B. Opiate signaling regulates microglia activities in the invertebrate nervous system. Gen. Pharmacol., 1997, v. 29, № 1, p. 39-47.