Immunostimulation and immunotherapy in the complex treatment of bladder cancer

Abstract

In 32 out of 49 patients with bladder tumors, a decrease in immunity was revealed, more pronounced in patients with tumors at the T4 stage. In 12 patients, nonspecific immunostimulation with BCG vaccine was carried out 12-30 days before chemoradiation treatment. Due to this, in 6 of them, the level of the nonspecific immune system slightly increased and the immunosuppressive effect of chemoradiation therapy decreased. 5 patients with advanced stages of bladder cancer received nonspecific immunotherapy with BCG vaccine according to Toris. 2 of them showed subjective, and 1 - objective improvement. The results of the study give reason to consider the use of immunostimulation in the complex treatment of patients with bladder cancer advisable. Further development of indications and schemes of immunotherapy in patients with advanced stages of the disease is required.

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RIGHTS & PERMISSIONS

Strotsky A.V., Grigorovich N.A.