The role of myoepithelial cells in the morphogenesis of pleomorphic adenomas of the salivary glands and their identification

Abstract

The morphogenesis of 15 pleomorphic adenomas was studied. Identification of myoepithelial cells was carried out by immunohistochemical method using polyclonal antibodies to myosin, human carbonic anhydrase III, monoclonal antibodies to proteins of intermediate filaments of cytokeratin polypeptides No. 8 (clone H 1), No. 17 (clone E 3) and No. 18 (clone C 12). Myoepithelial, epithelial and other cells are involved in the morphogenesis of the studied tumors. It is recommended to use antibodies to myosin, carbonic anhydrase III, keratins No. 8, 17, 18 in the diagnosis of pleomorphic adenomas of the salivary glands.

Keywords

salivary glands / pleomorphic adenoma / morphogenesis

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