Neurobiological mechanisms of transcranial magnetic stimulation and its comparative efficacy in tension headache and migraine

Abstract

Transcranial magnetic stimulation (TMS) is one of the nonpharmacological methods to affect the central nervous system. This approach allows a noninvasive stimulation of the cerebral cortex. The method is based on the ability of magnetic fields to penetrate the bone and muscle structures. The induced magnetic field depolarizes the neuronal membrane, and the generated action potential propagates through the conducting pathways. In the review, the biophysical effects of TMS, as well as its neural, immune, mediator and macro effects are analyzed. The main contraindications to TMS and its side effects are considered. Nonpharmacological treatment of tension headache (TH) and migraine is a promising direction, since the incidence of these types of primary headaches reaches 40-65 and 11-22%, respectively. In the article the current state of study of various modes and durations of TMS procedure, and the site of exposure in TH and migraine are considered. In recent years there is noted an increase in the number of evidence-based randomized, placebo-controlled studies on the effectiveness of TMS in migraine therapy. Much attention is given to evaluation of the effect of TMS in migraine. There is much evidence of the positive effect of this procedure. However, the amount of examined volunteers does not provide the highest level of evidence. Experiments on animals and use of functional neurovisualization techniques contribute to understanding of the mechanisms of TMS effect. Active participation of physiologists, neurophysiologists and biophysicists in these research works will permit evaluation of the effectiveness of TMS in nonpharmacological treatment of patients with pain syndrome. This approach will improve the working capacity and quality of life in TH and migraine.

Keywords

transcranial magnetic stimulation / tension headache / migraine / neurobiological mechanisms / de-pression / intensity and incidence of pain syndrome

References

[1] Eldaief M, Pascual-Leone A. Transcranial magnetic stimulation in neurology. Clinical practice. 2013; 12:519-25.

[2] Eldaief M., Pascual-Leone A. Transcranial magnetic stimulation in neurology // Clinical practice. 2013. Vol. 12. P. 519-525.

[3] Deblieck C, Thompson B, Iacoboni M, et al. Correlation between motor and phosphene thresholds: a transcranial magnetic stimulation study. Hum Brain Mapp. 2008;6:662-70.

[4] Deblieck C., Thompson B., Iacoboni M., et al. Correlation between motor and phosphene thresholds: a transcranial magnetic stimulation study // Hum. Brain Mapping. 2008. Vol. 6. P. 662-670.

[5] Dodick DW, Schembri CT, Helmuth M, et al. Transcranial magnetic stimulation for migraine: a safety review. Head-ache. 2010;50(7):1153-63. doi:10. 1111/j.1526-4610.2010.01697.x

[6] Dodick D.W, Schembri C.T, Helmuth M., et al. Transcranial magnetic stimulation for migraine: a safety review // Headache. 2010. Vol. 50, №7. P. 1153-1163. doi:10.1111/j.1526-4610.2010.0169 7.x

[7] Sorochinskiy AA. Transkranial'naya magnitnaya stimulyatsiya. Izvestiya Yuzhnogo Federal'nogo Universiteta. 2010;110(9):207-10. (In Russ).

[8] Сорочинский А.А. Транскраниальная магнитная стимуляция // Известия Южного федерального университе-та. 2010. T. 110, №9. С. 207-210.

[9] Sorokina ND, Selitskiy GV, Smirnov VM. Izmenenie bioelektricheskoy aktivnosti mozga pod vliyaniem oposredo-vannogo kratkovremennogo peremennogo magnitnogo polya u zdorovykh i bol'nykh epilepsiey. Rossiyskiy Med-itsinskiy Zhur-nal. 2012;6:11-4. (In Russ).

[10] Сорокина Н.Д., Селицкий Г.В., Смирнов В.М. Изменение биоэлектрической активности мозга под влиянием опосредованного кратковременного переменного магнитного поля у здоровых и больных эпилепсией // Рос-сийский медицинский журнал. 2012. №6. C. 11-14.

[11] Voytenkov VB, Mally J, Skripchenko NV, et al. Transkranial'naya magnitnaya stimulyatsiya kak diagnosticheskaya i terapevticheskaya metodika. Nevrologicheskiy Zhurnal. 2015;20(5):4-13. (In Russ).

[12] Войтенков В.Б., Mally J., Скрипченко Н.В., и др. Транскраниальная магнитная стимуляция как диагностиче-ская и терапевтическая методика // Нев-рологический журнал. 2015. Т. 20, №5. С. 4-13.

[13] Chervyakov AV, Piradov MA, Savitskaya NG, et al. Novyy shag k personifitsirovannoy meditsine. Navigatsionnaya sistema transkranial'noy magnit-noy stimulyatsii (NBS eXimia Nexstim). Annaly Nevrologii. 2012;6(3):37-46. (In Russ).

[14] Червяков А.В., Пирадов М.А., Савицкая Н.Г., и др. Новый шаг к персонифицированной ме-дицине. Навигаци-онная система транскраниальной магнитной стимуляции (NBS eXimia Nexstim) // Анналы неврологии. 2012. Т. 6, №3. С. 37-46.

[15] Chervyakov AV, Piradov MA, Nazarova MA, et al. Kartirovanie motornogo predstavitel'stva m. abductor pollicis brevis u zdorovykh dobrovol'tsev s primeneniem navigatsionnoy transkranial'noy magnitnoy stimulyatsii NBS eX-imia NEXSTIM. Annaly Klinicheskoyi Eksperimental'noy Nevrolo-gii. 2012; 6(3):14-6. (In Russ).

[16] Червяков А.В., Пирадов М.А., Назарова М.А., и др. Картирование моторного представительства m. abductorpollicisbrevis у здоровых добровольцев с применением навигационной транскраниальной магнитной стимуляции NBS eXimia NEXSTIM // Анналы клинической и экспериментальной неврологии. 2012. Т. 6, №3. C. 14-16.

[17] Rossi S, Hallett M, Rossini P, et al. Safety of TMS Consensus Group. Clinical safety, ethical considerations, and ap-plication guidelines for the use of transcranial magnetic stimulation in clinical practice and research. Clin Neurophysiol. 2009;120 (12): 2008-39. doi:10.1016/j.clinph.2009.08.016

[18] Rossi S., Hallett M., Rossini P., et al. Safety of TMS Consensus Group. Clinical safety, ethical considerations, and application guidelines for the use of transcranial magnetic stimulation in clinical practice and research // Clin Neuro-physiol. 2009. Vol. 120, №12. P. 2008-2039. doi:10.1016/j. clinph.2009.08.016

[19] Bingi VN, Savin AV. Fizicheskie problem deyst-viya slabykh magnitnykh poley na biologicheskie sistemy. Uspekhi Fizicheskikh Nauk. 2003;173(3): 265-300. (In Russ).

[20] Бинги В.Н., Савин А.В. Физические проблемы действия слабых магнитных полей на биологические системы // Успехи физических наук. 2003. T. 173, №3. C. 265-300.

[21] Sorokina ND, Selitskii GV, Karpov VA. Indirect short-term influences of alternating magnetic fields on the brain in epilepsy. Neuroscience and behavioral physiology. 2000;30(1):5-8.

[22] Sorokina N.D., Selitskii G.V., Karpov V.A. Indirect short-term influences of alternating magnetic fields on the brain in epilepsy //Neuroscience and behavioral physiology. 2000. Vol. 30, №1. P. 5-8.

[23] Bortoletto M, Veniero D, Thut G, et al. The contribution of TMS-EEG coregistration in the exploration of the human cortical connectome. Neurosci Biobehav Rev. 2015;49:114-24. doi:10. 1016/j.neubiorev.2014.12.014

[24] Bortoletto M., Veniero D., Thut G., et al. The contribution of TMS-EEG coregistration in the exploration of the hu-man cortical connectome // Neurosci. Biobehav. Rev. 2015. Vol. 49. P. 114-124. doi:10.1016/j.neubiorev.2014.12.014

[25] Huerat P, Volpe T. Synaptic plasticity and oscillations. J Neuro Engin Rehab. 2009;6:7-11.

[26] Huerat P., Volpe T. Synaptic plasticity and oscillations // J. NeuroEngin. Rehab. 2009. Vol. 6. P. 7-11.

[27] Keck ME, Welt T., Müller MB, et al. Repetitive transcranial magnetic stimulation increases the release of dopamine in the mesolimbic and mesostriatal system. Neuropharmacology. 2002;43 (1):101-9.

[28] Keck M.E., Welt T., Müller M.B., et al. Repetitive transcranial magnetic stimulation increases the release of dopa-mine in the mesolimbic and mesostriatal system // Neuropharmacology. 2002. Vol. 43, №1. P. 101-109.

[29] Pradhan S, Kirton A., MacQueen G, et al. The effect of repetitive transcranial magnetic stimulation on dorsolateral prefrontal glutamate in youth with treatment-resistant depression. BMC Proceedings. 2015;9(1):A9. doi:10.1186/1753-6561-9-S1-A9

[30] Pradhan S., Kirton A., MacQueen G., et al. The effect of repetitive transcranial magnetic stimulation on dorsolateral prefrontal glutamate in youth with treatment-resistant depression // BMC Proce-edings. 2015. Vol. 9. Suppl 1. P. A9. doi10.1186/ 1753-6561-9-S1-A9

[31] Evers S, Hengst K, Pecuch PW. The impact of repetitive transcranial magnetic stimulation on pituitary hormone lev-els and cortisol in healthy subjects. J Affect Disord. 2001;66:83-8.

[32] Evers S., Hengst K., Pecuch P.W. The impact of repetitive transcranial magnetic stimulation on pituitary hormone levels and cortisol in healthy subjects // J. Affect. Disord. 2001. Vol. 66. P. 83-88.

[33] Valero-Cabre A, Payne BR, Rushmore J., et al. Impact of repetitive transcranial magnetic stimu-lation of the parietal cortex on metabolic brain activity: a 14C-2DG tracing study in the cat. Exp Brain Res. 2005;163:1-12.

[34] Valero-Cabre A., Payne B.R., Rushmore J., et al. Impact of repetitive transcranial magnetic stimulation of the parie-tal cortex on metabolic brain activity: a 14C-2DG tracing study in the cat // Exp. Brain Res. 2005. Vol. 163. P. 1-12.

[35] Andreou AP, Sprenger T., Goadsby PJ. Cortical modulation of thalamic function during cortical spreading depres-sion- unraveling a new central mechanism involved in migraine aura. J Headache Pain. 2013;14(1):I6. doi:10.1186/1129-2377-14-S1-I6

[36] Andreou A.P., Sprenger T., Goadsby P.J. Cortical modulation of thalamic function during cortical spreading depres-sion- unraveling a new central mechanism involved in migraine aura // J. Headache Pain. 2013. Vol. 14. Supp l. P. I6. doi: 10.1186/1129-2377-14-S1-I6

[37] Chervyakov AV, Poydasheva AG, Korzhova YuE, et al. Sovremennye terapevticheskie vozmozhnosti ritmicheskoy transkranial'noy magnitnoy stimulyatsii v lechenii zabolevaniy nervnoy sistemy. Russkiy Meditsinskiy Zhurnal. 2014;22:1567-72. (In Russ).

[38] Червяков А.В., Пойдашева А.Г., Коржова Ю.Е., и др. Современные терапевтические возможности ритмиче-ской транскраниальной магнитной стимуляции в лечении заболеваний нервной системы // Русский медицин-ский журнал. 2014. №22. P. 1567-1572.

[39] Chervyakov AV, Poydasheva AG, Korzhova YuE, et al. Ritmicheskaya transkranial'naya magnitnaya sti-mulyatsiya v nevrologii i psikhiatrii. Zhurnal Nevro-logii i Psikhiatrii imeni SS Korsakova. 2015; 12:7-18. (In Russ). doi:10.17116/jnevro20151151127-18

[40] Червяков А.В., Пойдашева А.Г., Коржова Ю.Е., и др. Ритмическая транскраниальная магнитная стимуляция в неврологии и психиатрии // Журнал неврологии и психиатрии им. С.С. Корсакова. 2015. №12. С. 7-18. doi:10.17116/j.nevro 20151151127-18

[41] Misra UK, Kalita J, Tripathi GM, et al. Role of β endorphin in pain relief following high rate repetitive transcranial magnetic stimulation in migraine. Brain Stimul. 2017;10(3):618-23. doi: 10.1016/j.brs.2017.02.006

[42] Misra U.K., Kalita J., Tripathi G.M., et al. Role of β endorphin in pain relief following high rate repetitive transcranial magnetic stimulation in migraine // Brain Stimul. 2017. Vol. 10, №3. P. 618-623. doi:10.1016/j.brs.2017.02.006

[43] Lipton RB, Dodick DW, Silberstein SD, et al. Single-pulse transcranial magnetic stimulation for acute treatment of migraine with aura: a randomised, double-blind, parallel-group, sham-controlled trial. Lancet Neurolology. 2010;9(4): 373-80. doi:10.1016/S1474-4422(10)70054-5

[44] Lipton R.B., Dodick D.W, Silberstein S.D., et al. Single-pulse transcranial magnetic stimulation for acute treatment of migraine with aura: a randomised, double-blind, parallel-group, sham-controlled trial // Lancet Neurolology. 2010. Vol. 9, №4. P. 373-380.doi:10.1016/S1474-4422(10)70054-5

[45] Almaraz AC, Dilli E, Dodick DW. The effect of prophylactic medications on TMS for migraine aura. Headache. 2010;50(10):1630-3. doi:10.1111/ j.1526-4610.2010.01787.x

[46] Almaraz A.C., Dilli E., Dodick D.W. The effect of prophylactic medications on TMS for migraine aura // Headache. 2010. Vol. 50, №10. Р. 1630-1633. doi:10.1111/j.1526-4610.2010.01787.x

[47] Bhola R, Kinsella E, Giffin N, et al. Single-pulse transcranial magnetic stimulation (sTMS) for the acute treatment of migraine: evaluation of outcome data for the UK post market pilot program. The Journal of Headache and Pain.2015;16:51. doi:10.1186/s10194-015-0535-3

[48] Bhola R., Kinsella E., Giffin N., et al. Single-pulse transcranial magnetic stimulation (sTMS) for the acute treatment of migraine: evaluation of outcome data for the UK post market pilot program // The Journal of Headache and Pain. 2015. №16. P. 51. doi:10.1186/s10194-015-0535-3

[49] Brüggenjürgen B, Bake T, Bhogal R, et al. Cost impact of a noninvasive, portable device for patient self administra-tion of chronic migraine in a UK National Health Service setting. Springer Plus. 2016;5:1249-56. doi:10.1186/s40064-016-2924-8

[50] Brüggenjürgen B., Bake T., Bhogal R., et al. Cost impact of a non-invasive, portable device for patient self-administration of chronic migraine in a UK National Health Service setting // Springer Plus. 2016. №5. P. 1249-1256. doi:10.1186/s40064 -016-2924-8

[51] Lan LH, Zhang XN, Li XP, et al. The efficacy of transcranial magnetic stimulation on migraine: a meta-analysis of randomized controlled trails. Journal of Head acheand Pain. 2017;18:86. doi: 10.1186/s10194-017-0792-4

[52] Lan L.H., Zhang X.N., Li X.P. et al. The efficacy of transcranial magnetic stimulation on migraine: a meta-analysis of randomized controlled trails // Journal of Headache and Pain. 2017. Vol. 18. P. 86. doi:10.1186/s10194-017-0792-4

[53] Naeije G, Y, Ligot N, et al. Occipital transcranial magnetic stimulation discriminates transient neurological symptoms of vascular origin from migraine aura without headache. Europhysiologie Clinique-Clinical Neurophysiology. 2017;47(4): 269-74. doi:10.1016/j.neucli.2017.05.093

[54] Naeije G., Fogang Y., Ligot N., et al. Occipital transcranial magnetic stimulation discriminates transient neurological symptoms of vascular origin from migraine aura without headache // Europhysiologie Clinique-Clinical Neurophysi-ology. 2017. Vol. 47, №4. P. 269-274. doi: 10.1016/ j.neucli. 2017.05.093

[55] Kalita J, Bhoi SK, Misra UK. Effect of high rate rTMS on somatosensory evoked potential in migraine. Cephalalgia. 2016;37(13):1222-30. doi: 10.1177/0333102416675619

[56] Kalita J., Bhoi S.K., Misra U.K. Effect of high rate rTMS on somatosensory evoked potential in migraine // Cephalal-gia. 2017. Vol. 37, №13. P. 1222-1230. doi:10.1177/0333102416675619

[57] Andreou AP, Holland PR, Akerman S, et al. Transcranial magnetic stimulation and potential cortical and trigemi-nothalamic mechanisms in migraine. Brain. 2016;139(7):2002-14. doi:10.10 93/brain/aww118

[58] Andreou A.P., Holland P. R., Akerman S., et al. Transcranial magnetic stimulation and potential cortical and trigemi-nothalamic mechanisms in migraine // Brain. 2016. Vol. 139, №7. P. 2002-2014. doi:10.1093/brain/aww118

[59] Rapinesi C, Del Casale A, Scatena P, et al. Add-on deep Transcranial Magnetic Stimulation (dTMS) for the treatment of chronic migraine: A preli-minary study. Neuroscience Letters. 2016;623(3): 7-12. doi:10.1016/j.neulet.2016.04.058

[60] Rapinesi C., Del Casale A., Scatena P., et al. Add-on deep Transcranial Magnetic Stimulation (dTMS) for the treat-ment of chronic migraine: a preliminary study // Neuroscience Letters. 2016. Vol. 623, №3. P. 7-12. doi:10.1016/j.neulet.2016.04.058

[61] Misra UK, Kalita J, Bhoi SK. High frequency repetitive transcranial magnetic stimulation (rTMS) is effective in mi-graine prophylaxis: an open labeled study. Neurological Research. 2012;34(6): 547-55. doi:10.1179/1743132812Y.0000000045

[62] Misra U.K., Kalita J., Bhoi S.K. High frequency repetitive transcranial magnetic stimulation (rTMS) is effective in migraine prophylaxis: an open labeled study // Neurological Research. 2012. Vol. 34, №6. P. 547-551. doi:10.1179/1743132812Y. 0000000045

[63] Kalita J, Laskar S, Bhoi SK, et al. Efficacy of single versus three sessions of high rate repetitive transcranial magnetic stimulation in chronic migraine and tension-type headache. Journal of Neurology. 2016;263(11):2238-46. doi:10.1007/ s00415-016-8257-2

[64] Kalita J., Laskar, S., Bhoi S.K., et al. Efficacy of single versus three sessions of high rate repetitive transcranial mag-netic stimulation in chronic migraine and tension-type headache // Journal of Neurology. 2016. Vol. 263, №11. P. 2238-2246. doi:10.1007/s00415-016-8257-2

[65] Belyaev AA, Isaykova EI, Son AS. Lechenie migreni metodom transkranial'noy magnitnoy stimulyatsii. Mezhdu-narodnyy Nevrologicheskiy Zhurnal. 2015;73(3):85-9. (In Russ).

[66] Беляев А.А., Исайкова Е.И., Сон А.С. Лечение мигрени методом транскраниальной магнитной стимуляции // Международный неврологический журнал. 2015. Т. 73. №3. С. 85-89.

[67] Puledda F, Goadsby PJ. The Role of noninvasive neuromodulation in migraine management. European Neurological Review. 2016;11(2):106-108. doi:10.17925/ENR.2016.11.02.106

[68] Puledda F., Goadsby P.J. The Role of noninvasive neuromodulation in migraine management // European Neurolog-ical Review. 2016. Vol. 11, №2. P. 106-108. doi:10.17925/ENR.2016.11.02.106

[69] Azimova YuE, Rachin AP, Ishchenko KA, et al. Innovatsionnye metody lecheniya migreni. Russkiy Meditsinskiy Zhurnal. 2015;23(3):27-30. (In Russ).

[70] Азимова Ю.Э., Рачин А.П., Ищенко К.А., и др. Инновационные методы лечения мигрени // Русский медицин-ский журнал. 2015. Т. 23, №3. С. 27-30.

[71] Conforto AB, Amaro E, Goncalves AL, et al. Randomized, proof-of-principle clinical trial of active transcranial magnetic stimulation in chronic migraine. Cephalalgia. 2014;34(6):464-2. doi:10. 1177/0333102413515340

[72] Conforto A.B, Amaro E., Goncalves A.L., et al. Randomized, proof-of-principle clinical trial of active transcranial magnetic stimulation in chronic migraine // Cephalalgia. 2014. Vol. 34, Suppl. 6. P. 464-472. doi:10.1177/0333102413515340

[73] Martelletti P, Jensen RH, Antal A, et al. Neuromodulation of chronic headaches: position statement from the Euro-pean Headache Federation. J Headache Pain. 2013;14(1):86-92.

[74] Martelletti P., Jensen R.H., Antal A., et al. Neuromodulation of chronic headaches: position statement from the Eu-ropean Headache Federation // J. Headache Pain. 2013. Vol. 14, №1. P. 86-92.

[75] Iskra DA, Frunza DN. Povtornaya transkranial'-naya magnitnaya stimulyatsiya v lechenii khroni-cheskikh golov-nykh boley napryazheniya. Vestnik Rossiyskoy Voenno-Meditsinskoy Akademii. 2012; 39(9):34-8. (In Russ).

[76] Искра Д.А., Фрунза Д.Н. Повторная транскраниальная магнитная стимуляция в лечении хронических голов-ных болей напряжения // Вестник Российской военно-медицинской академии. 2012. Т. 39, №3. C. 34-38.

[77] Shirshova EV, Akarachkova ES. Primenenie mag-nitnoy transkranial'noy stimulyatsii pri khroniche-skoy golovnoy boli napryazheniya. Zhurnal Nevrologii i Psikhiatrii imeni SS Korsakova. 2012;7(1):62-4. (In Russ).

[78] Ширшова Е.В., Акарачкова Е.С. Применение магнитной транскраниальной стимуляции при хронической го-ловной боли напряжения // Журнал неврологии и психиатрии им. С.С. Корсакова. 2012. Т. 7, №1. С. 62-64.

[79] Paillere ML, Galinowski A, Rinquenet D et al. Influence of prefrontal target region on the efficacy of repetitive tran-scranial magnetic stimulation in patients with medication-resistant depression: a [(18)F]-fluorodeoxyglucose PET and MRI study. International journal of Neuropsycopharmacology. 2010;13(1):45-59. doi:10.1017/S146114570900008X

[80] Paillere M.L., Galinowski A., Rinquenet D., et al. Influence of prefrontal target region on the efficacy of repetitive transcranial magnetic stimulation in patients with medication-resistant depression: a [(18)F]-fluorodeoxyglucose PET and MRI study // International Journal of Neuropsycopharmacology. 2010. Vol. 13, №1. P. 45-59. doi:10.1017/S14611 4570900008X

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Sorokina N.D., Pertsov S.S., Selitsky G.V.