Impact of COVID-19 Epidemic on Morbidity and Mortality of Cancer Patients in the Ryazan Region

Abstract

INTRODUCTION: In 2020, humanity faced a pandemic of a new infection a Severe Acute Respiratory Syndrome-related Corona Virus 2 (SARS-CoV-2) that had a significant impact on the economic, social, including medical, aspects of our life. Against the background of these changes, oncological diseases, like many other comorbid pathologies, seemed to fade into insignificance. But, as we understand, they have not lost their relevance, but only ‘retreated to the shadow’ for a while. Study of the basic statistical indicators used for evaluating the prevalence of cancer pathology and the results of the work of oncological service, helps analyze and understand the processes occurring in conditions of reorientation of medical measures for combating the pandemic.

AIM: To study changes in the main indicators of the oncology service of the Ryazan region during the COronaVIrus Disease 2019 (COVID-2019) epidemic.

MATERIALS AND METHODS: The main statistical indicators of morbidity, detestability and mortality from malignant neoplasms (MNs) in the Ryazan region were analyzed on the basis of statistical forms of federal statistical observation No. 7 (Form No. 7) ‘Record of MNs’, reports and data of cancer registry for 2012–2022. The most relevant statistical indicators were analyzed, data on most common and relevant tumor localizations were separately considered.

RESULTS: At the height of COVID-19 pandemics in 2020–2021, a sharp reduction of the total number of identified MN cases was observed a seeming decline of ‘mortality’. At the same time, there was an increase in the proportion of patients with advanced IV stage pathology of lungs, stomach, and colorectal cancer, which, in turn, led in some cases to increase in one-year mortality, and to general increase in mortality among cancer patients. To note, despite a complicated situation associated with non-observance of the terms of the periodic medical examinations, reprofiling of a number of medical organizations and increased load on the primary medical care organizations, the oncology service of the Ryazan region showed a not that catastrophic impairment of the main statistical indicators, and of some of them a proportion of detection of early stages, results of treatment of tumors of visual localization even a positive dynamics. In 2022, officially registered cancer incidence rates in our region returned to previous values comparable to 2019.

CONCLUSION: The experience of recent years should help in developing measures to prevent both the spread of similar epidemiological diseases and measures to prevent a decline of the quality of specialized medical care, in particular, in the field of oncology.

Keywords

COVID-19 / malignant neoplasms / statistical indicators / Ryazan region

References

[1] WHO. Coronavirus disease (COVID-19) [Internet]. Available at: https://www.who.int/emergencies/diseases/novel-coronavirus-2019. Accessed: 2023 May 24. (In Russ).

[2] ВОЗ. Коронавирус COVID-19 [Интернет]. Доступно по: https://www.who.int/ru/emergencies/diseases/novel-coronavirus-2019. Ссылка активна на 24.05.2023.

[3] Decree of the Government of the Russian Federation No. 710-r of March 21, 2020 «O vremennom priostanovlenii provedeniya Vserossiyskoy dispanserizatsii vzroslogo naseleniya Rossiyskoy Federatsii». Available at: https://www.garant.ru/products/ipo/prime/doc/73681079/. Accessed: 2023 May 24. (In Russ).

[4] Распоряжение Правительства Российской Федерации от 21 марта 2020 года № 710-р «О временном приостановлении проведения Всероссийской диспансеризации взрослого населения РФ». Доступно по: https://www.garant.ru/products/ipo/prime/doc/73681079/. Ссылка активна на 24.05.2023.

[5] Stupak VS, Zubko AV, Manoshkina EM, et al. Healthcare in Russia during the COVID-19 pandemic: challenges, systemic issues, and addressing priorities. Russian Journal of Preventive Medicine. 2022;25(11):21–7. (In Russ). doi: 10.17116/profmed20222511121

[6] Ступак В.С., Зубко А.В., Маношкина Е.М., и др. Здравоохранение России в период пандемии COVID-19: вызовы, системные проблемы и решение первоочередных задач // Профилактическая медицина. 2022. Т. 25, № 11. С. 21–27. doi: 10.17116/profmed20222511121

[7] Malinnikova EYu. New coronaviral infection. Today’s look at the pandemic of the XXI century. Infectious Diseases: News, Opinions, Training. 2020;9(2):18–32. (In Russ). doi: 10.33029/2305-3496-2020-9-2-18-32

[8] Малинникова Е.Ю. Новая коронавирусная инфекция. Сегодняшний взгляд на пандемию XXI века // Инфекционные болезни: новости, мнения, обучение. 2020. Т. 9, № 2. С. 18–32. doi: 10.33029/2305-3496-2020-9-2-18-32

[9] Timerbulatov VM, Timerbulatov MV. Health care during and after COVID-19. Herald of the Academy of Sciences of the Republic of Bashkortostan. 2020;35(2):77–86. (In Russ). doi: 10.24411/1728-5283-2020-10209

[10] Тимербулатов В.М., Тимербулатов М.В. Здравоохранение во время и после пандемии COVID-19 // Вестник Академии наук Республики Башкортостан. 2020. Т. 35, № 2 (98). С. 77–86. doi: 10.24411/1728-5283-2020-10209

[11] Bobotina NA, Dautbayev DG, Gimaziyeva AI, et al. Analysis of Awareness of Medical Students and Medical Workers of the Republic of Bashkortostan and Ryazan Region of Coronavirus Infection COVID-19. Nauka Molodykh (Eruditio Juvenium). 2023;11(1):39–48. (In Russ). doi: 10.23888/HMJ202311139-48

[12] Боботина Н.А., Даутбаев Д.Г., Гимазиева А.И., и др. Анализ осведомленности студентов-медиков и медицинских работников республики Башкортостан и Рязанской области о корона- вирусной инфекции COVID-19 // Наука молодых (Eruditio Juvenium). 2023. Т. 11, № 1. С. 39–48. doi: 10.23888/HMJ202311139-48

[13] Gantsev ShKh, Rustamkhanov RA. Cancer during the pandemic of coronavirus infection COVID-19. Bashkortostan Medical Journal. 2020;15(3):51–8. (In Russ).

[14] Ганцев Ш.Х., Рустамханов Р.А. Рак во время пандемии коронавирусной инфекции COVID-19 // Медицинский вестник Башкортостана. 2020. Т. 15, № 3 (87). С. 51–58.

[15] Kaprin AD, Starinskiy VV, Shakhzadova AO, editors. Sostoyaniye onkologicheskoy pomoshchi naseleniyu Rossii v 2021 godu. Moscow; 2022. (In Russ).

[16] Каприн А.Д., Старинский В.В., Шахзадова А.О., ред. Состояние онкологической помощи населению России в 2021 году. М.; 2022.

[17] Kaprin AD, Starinskiy VV, Shakhzadova AO, editors. Zlokachestvennyye novoobrazovaniya v Rossii v 2021 godu (zabolevayemost’ i smertnost’). Moscow; 2022. (In Russ).

[18] Каприн А.Д., Старинский В.В., Шахзадова А.О., ред. Злокачественные новообразования в России в 2021 году (заболеваемость и смертность). М.; 2022.

[19] Federal State Statistics Service of the Russian Federation. Available at: http://government.ru/department/456/events/. Accessed: 2023 May 24. (In Russ).

[20] Федеральная служба государственной статистики РФ. Доступно по: http://government.ru/department/456/events/. Ссылка активна на 24.05.2023.

[21] Order of the Federal State Statistics Service No. 866 dated December 27, 2016 «Ob utverzhdenii statisticheskogo instrumentariya dlya organizatsii Ministerstvom zdravookhraneniya Rossiyskoy Federatsii federal’nogo statisticheskogo nablyudeniya v sfere okhrany zdorov’ya» Available at: https://www.garant.ru/products/ipo/prime/doc/71480580/. Accessed: 2023 May 24. (In Russ).

[22] Приказ Федеральной службы государственной статистики от 27 декабря 2016 г. № 866 «Об утверждении статистического инструментария для организации Министерством здравоохранения Российской Федерации федерального статистического наблюдения в сфере охраны здоровья». Доступно по: https://www.garant.ru/products/ipo/prime/doc/71480580/. Ссылка активна на 24.05.2023.

[23] Fomin VV, Royuk VV, Reshetnikov VA, et al. Analysis of In-Hospital Mortality of Patients with New Coronavirus Infection (COVID-19) of Clinical Centre of Sechenov University. I. P. Pavlov Russian Medical Biological Herald. 2023;31(3):381–9. (In Russ). doi: 10.17816/PAVLOVJ569334

[24] Фомин В.В., Роюк В.В., Решетников В.А., и др. Анализ внутрибольничной летальности у пациентов с новой коронавирусной инфекцией (COVID-19) Клинического центра Сеченовского университета // Российский медико-биологический вестник имени академика И. П. Павлова. 2023. Т. 31, № 3. C. 381–389. doi: 10.17816/PAVLOVJ569334

[25] Kaprin AD, Gameeva EV, Polyakov AA, et al. Impact of the COVID-19 pandemic on the oncological practice. Siberian Journal of Oncology. 2020;19(3):5–22. (In Russ). doi: 10.21294/1814-4861-2020-19-3-5-22

[26] Каприн А.Д., Гамеева Е.В., Поляков А.А., и др. Влияние пандемии COVID-19 на онкологическую практику // Сибирский онкологический журнал. 2020. Т. 19, № 3. С. 5–22. doi: 10.21294/1814-4861-2020-19-3-5-22

[27] Burki TK. Cancer care in the time of COVID-19. Lancet Oncol. 2020;21(5):628. doi: 10.1016/S1470-2045(20)30201-1

[28] Burki T.K. Cancer care in the time of COVID-19 // Lancet Oncol. 2020. Vol. 21, No. 5. P. 628. doi: 10.1016/S1470-2045(20)30201-1

[29] Mayor S. COVID-19: impact on cancer workforce and delivery of care. Lancet Oncol. 2020;21(5):633. doi: 10.1016/s1470-2045(20)30240-0

[30] Mayor S. COVID-19: impact on cancer workforce and delivery of care // Lancet Oncol. 2020. Vol. 21, № 5. P. 633. doi: 10.1016/ s1470-2045(20)30240-0

[31] Passaro A, Addeo A, von Garnier C, et al. ESMO management and treatment adapted recommendations in the COVID-19 era: Lung Cancer. ESMO Open. 2020;5(Suppl 3):e000820. doi: 10.1136/esmoopen-2020-000820

[32] Passaro A., Addeo A., von Garnier C., et al. ESMO management and treatment adapted recommendations in the COVID-19 era: Lung Cancer // ESMO Open. 2020. Vol. 5, Suppl. 3. P. e000820. doi: 10.1136/esmoopen-2020-000820

[33] Poddubnaya IV, Sychev DA, Abuzarova GR, et al. Cancer patient management during the COVID-19 pandemic. Training module. Version 2 from 30.04.2020. Journal of Modern Oncology. 2020;22(2):56–73. (In Russ). doi: 10.26442/18151434.2020.2.200138

[34] Поддубная И.В., Сычев Д.А., Абузарова Г.Р., и др. Особенности ведения онкологических пациентов во время пандемии коронавирусной инфекции COVID-19. Учебный модуль. Версия 2. 30.04.2020 // Современная Онкология. 2020. Т. 22, № 2. С. 56–73. doi: 10.26442/18151434.2020.2.200138

[35] Wang H, Zhang L. Risk of COVID-19 for patients with cancer. Lancet Oncol. 2020;21(4):e181. doi: 10.1016/S1470-2045(20)30149-2

[36] Wang H., Zhang L. Risk of COVID-19 for patients with cancer // Lancet Oncol. 2020. Vol. 21, № 4. e181. doi: 10.1016/S1470-2045(20)30149-2

[37] Starodubov VI, Stupak VS, Manoshkina EM, et al. Trends in Morbidity and Hospital Lethality from Neoplasms before and during the New Coronavirus Infection COVID-19. Annals of the Russian Academy of Medical Sciences. 2021;76(6):612–21. (In Russ). doi: 10.15690/vramn1648

[38] Стародубов В.И., Ступак В.С, Маношкина Е.М., и др. Тенденции заболеваемости и больничной летальности от новообразований до и во время новой коронавирусной инфекции COVID-19 // Вестник Российской академии медицинских наук. 2021. Т. 76, № 6. С. 612–621. doi: 10.15690/vramn1648

[39] Lopukhova VA, Tarasenko IV, Shestavina NV, et al. Tendencies of primary morbidity and mortality of population of the Kursk region from malignant neoplasms. Nauka Molodykh (Eruditio Juvenium). 2020;8(2):202–7. (In Russ). doi: 10.23888/HMJ202082202-207

[40] Лопухова В.А., Тарасенко И.В., Шеставина Н.В., и др. Тенденции первичной заболеваемости и смертности населения Курской области от злокачественных новообразований // Наука молодых (Eruditio Juvenium). 2020. Т. 8, № 2. С. 202–207. doi: 10.23888/HMJ202082202-207

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