THE INFLUENCE OF EXPERIMENTAL SUBACUTE HYPOBARIC HYPOXIA ON P-GLYCOPROTEIN FUNCTIONAL ACTIVITY

doi:10.17816/PAVLOVJ2013160-64

I.P. Pavlov Russian Medical Biological Herald ›› 2013, Vol. 21 ›› Issue (1) :60 -64. DOI: 10.17816/PAVLOVJ2013160-64

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THE INFLUENCE OF EXPERIMENTAL SUBACUTE HYPOBARIC HYPOXIA ON P-GLYCOPROTEIN FUNCTIONAL ACTIVITY

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Abstract

In a study on rabbits the effect of the experimental subacute hypobaric hypoxic hypoxia on the functional activity of ATP-dependent protein transporter P-glycoprotein (Pgp) was studied. Pgp activity was assessed by pharmacokinetic of it’s marker substrate fexofenadine. It was found that 4-hour hypoxic action leads to Pgp induction.

Keywords

MDR1 / glycoprotein-P / MDR1 / hypoxia / subacute hypobaric hypoxic hypoxia / fexofenadine / transporters / pharmacokinetics

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null. THE INFLUENCE OF EXPERIMENTAL SUBACUTE HYPOBARIC HYPOXIA ON P-GLYCOPROTEIN FUNCTIONAL ACTIVITY. I.P. Pavlov Russian Medical Biological Herald, 2013, 21(1): 60-64 DOI:10.17816/PAVLOVJ2013160-64

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