MOLECULAR AND BIOLOGICAL MARKERS IN THE DIAGNOSIS AND PROGNOSIS OF THE GASTRIC MUCOSA INTESTINAL METAPLASIA

doi:10.17816/PAVLOVJ2013111-17

I.P. Pavlov Russian Medical Biological Herald ›› 2013, Vol. 21 ›› Issue (1) :11 -17. DOI: 10.17816/PAVLOVJ2013111-17

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MOLECULAR AND BIOLOGICAL MARKERS IN THE DIAGNOSIS AND PROGNOSIS OF THE GASTRIC MUCOSA INTESTINAL METAPLASIA

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Abstract

The expression of molecular and biological markers in the intestinal metaplasia (IM) of the gastric mucosa on the basis of pathomorphological analysis was studied. It is shown that the follow useful prognostic and diagnostic value have been used: differentiation of intestinal transcription factor (CDX2), cytokeratin 7 (CK7), mucin (MUC 5 AC) and a marker of proliferative activity -Ki-67. The algorithm for pathomorphological diagnosis of gastric mucosa IM with using of immunohistochemical markers was suggested.

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molecular and biological markers / intestinal metaplasia of the gastric mucosa

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null. MOLECULAR AND BIOLOGICAL MARKERS IN THE DIAGNOSIS AND PROGNOSIS OF THE GASTRIC MUCOSA INTESTINAL METAPLASIA. I.P. Pavlov Russian Medical Biological Herald, 2013, 21(1): 11-17 DOI:10.17816/PAVLOVJ2013111-17

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References

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[1]	Бабак О.Я. Хронический атрофический гастрит - точка отсчёта начала канцерогенеза / О.Я. Бабак, Ю.В. Протас // Сучасна гастроентерологія. - 2005. -№ 5(25). - С. 9-14.

[2]	Поддубный Б.К. Современное состояние эндоскопической диагностики и лечения ранних форм рака пищевода и желудка / Б.К. Поддубный, Ю.П. Кувшинов, О.Н. Ефимов // Современная онкология. - 2000. - № 2. - С. 68-72.

[3]	Заридзе Д.Г. Эпидемиология и этиология злокачественных заболеваний / Д.Г. Заридзе // Канцерогенез. - М.: Научный мир, 2000. - С. 26-30.

[4]	Формирование групп риска по раку желудка / Л.Е. Денисов [и др.] // Кремлевская медицина. Клинич. вестн. - 1999. - № 1. - С. 13-17.

[5]	Шаназаров. Н.А. Рак желудка: учебное пособие / под ред. проф. А.В. Важенина. - Челябинск, 2001. - 29 с.

[6]	Indefinite for non-invasive neoplasia lesions in gastric intestinal metaplasia: the immunophenotype / M. Cassaro [et al.] // J. Clin. Pathol. - 2007. - Vol. 60. -P. 615-621.

[7]	Hamilton Stanley R. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Digestive System / Stanley R. Hamilton, Lauri A. Aaltonen. - Lyon: IARC Press, 2000. - 314 p.

[8]	The Ki-67 protein interacts with members of the heterochromatin protein 1 (HP1) family: a potential role in the regulation of higher-order chromatin structure / T. Scholzen [et al.] // J. Pathol. - 2002. -Vol. 196. - P. 135-144.