NEW CONCEPTS OF PHARMACODYNAMICS OF ECDYSTEROIDS

Abstract

In the review possible mechanisms of action of ecdysteroids in an organism of mammals are discussed: introduction in the lipid membrane; interaction with the special membrane receptors; interaction with the regulatory site of the receptors of the different molecules; activation nonspecial adaptation program.

Keywords

ecdysteroids / pharmacodynamics

References

[1] Селье Г. Стресс без дистресса / Г. Селье. - М.: Прогресс, 1979. - 122 с.

[2] Сыров В.Н. Сравнительное изучение анаболической активности фитоэкдистероидов, их 6-кетоаналогов и неробола в организме экспериментальных животных: автореф. дис.. канд. мед. наук / В.Н. Сыров. - Ташкент, 1979. - 35 с.

[3] Фитоэкдистероиды (естественные синтоксины) как модуляторы адаптивных программ организма при действии раздражителей внешней и внутренней среды / В.Н. Морозов [и др.]. - Тула: Изд-во ТулГУ, 2006. - 54 с.

[4] Электронный режим доступа: http://leuzea.ru/pdf/ecdysteroids_IVTN.pdf

[5] 20-Hydroxyecdysone decreases weight and hyperglycemia in a diet-induced obesity mice model / P. Kizelsztein [et al.] // Am. J. Physiol. Endocrin. Metab. - 2009. - Vol. 296(3).

[6] Berridge M.J. The versatility and universality of calcium signaling / M.J. Berridge, P. Lipp, M.D. Bootman // Nat. Rev. Mol. Cell. Biol. - 2000. - Vol. 1(1). - P. 11-21.

[7] Brann D.W. Emerging diversities in the mechanism of action of steroid hormones / D.W. Brann, L.B. Hendry, V.B. Mahesh // J. Steroid. Bioch. Mol. Biol. - 1995. - Vol. 52. - P. 113-133.

[8] C27 Steroid Hormones ecdyterone and calcitriol activates phosphoinositide messenger cascade in its early membrane phase of action / A.V. Kotsyuruba [et al.] // Ukr. Bioch. J. - 1999. - Vol. 71(1). - P. 27-32.

[9] Dinan L. Phytoecdysteroids: biological aspects / L. Dinan // Phytochem. - 2001. - Vol. 57. - P. 325-339.

[10] Ecdysterone induces acetylcholinesterase in mammalian brain / R.E. Catalan [et al.] // Comp. Bioch. Physiol. C. - 1984. - Vol. 78(1). - P. 193-195.

[11] Evans R.M. The steroid and thyroid hormone receptor superfamily / R.M. Evans // Science - 1988. - Vol. 240. - Р. 889-895.

[12] Evolution of pharmacologic specificity in the pregnane X receptor / S. Ekins [et al.] // BMC Evol. Biol. - 2008. - Vol. 8. - P. 103.

[13] G protein-coupled time travel: evolutionary aspects of GPCR research / H. Rompler [et al.] // Mol. Interv. - 2007. - Vol. 7. - P. 17-25.

[14] Lafont R. Practical uses for ecdysteroids in mammals including humans: an update / R. Lafont, L. Dinan // J. Insect. Sci. -2003. - Vol. 3, №7. - P. 30.

[15] Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways / C. Rommel [et al.] // Nature. Cell. Biol. -2001. - Vol. 3. - P. 1009-1013.

[16] Molecular determinants of differential ligand sensitivities of insect ecdysteroid receptors / S.F. Wang [et al.] // Mol. Cell. Biol. - 2000. - Vol. 20. - P. 3870-3879.

[17] Phytoecdysteroids and Vitamin D Analogues - Similarities in Structure and Mode of Action / N. Toth [et al.] // Curr. Med. Chem. - 2010. - Vol. 17(18). - P. 1974-1994.

[18] Phytoecdysteroids increase protein synthesis in skeletal muscle cells / J. Gorelick-Feldman [et al.] // J. Agric. Food. Chem. - 2008 - Vol. 28, № 56 (10). - P. 3532-3537.

[19] Potentiation of GABA-induced inhibition by 20-hydroxyecdysone, a neurosteroid, in cultured rat cortical neurons / S. Tsujiyama [et al.] // Japan. J. Pharmacol. - 1995. - Vol. 68. - P. 133-136.

[20] Rapid, nongenomic responses to ecdysteroids and catecholamines mediated by a novel Drosophila G-protein-coupled receptor / D.P. Srivastava [et al.] // J. Neurosci. - 2005. - Vol. 25(26). - P. 6145-6155.

[21] Raskin I. Phytoecdysteroids - Understanding their Anabolic Activity. Abstract of the dissertation PhD / I. Raskin - New Brunswick, New Jersey, 2009.

[22] Rhee S.G. Regulation of phosphoinositide-specific phospholipase C / S.G. Rhee // Annu. Rev. Biochem. - 2001. - Vol. 70. - P. 281-312.

[23] Rozengurt E. Mitogenic signaling pathways induced by G protein-coupled receptors / E. Rozengurt // J. Cell. Physiol. - 2007. - Vol. 213(3). - P. 589-602.

[24] Screening plants of European North-East Russia for ecdysteroids / V. Volodin [et al.] // Bioch. System. Ecol. - 2002. - Vol. 30. - Is. 6. - P. 525-578.

[25] Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta / B.A. Janowski [et al.] // Proceed. Nat. Acad. Scien. USA. - 1999. - Vol. 69. - P. 266-271.

[26] The ecdysteroid inducible gene expression system: unexpected effects of muristerone A and ponasterone A on cytokine signalling in mammalian cells / S. Constantino [et al.] // Eur. Cytok. Netw. - 2001. - Vol. 12. - P. 365-367.

[27] The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution / S.A. Jones [et al.] // Mol. Endocrin. - 2000. - Vol. 14. - P. 27-39.

[28] Tuganova A.V. The in vitro interaction of C27-steroids with the erythrocyte membranes depends on the sterol structure and concentration / A.V. Tuganova, A.V. Kotsyuruba // Cell. Mol. Biol. Lett. - 1996. - Vol. 1. - P. 129-135.

RIGHTS & PERMISSIONS

Shchulkin A.V., Yakusheva E.N., Davydov V.V., Darmograi V.N.