Influence of the thyroxine on the functional activity of the р-glycoprotein in the experiment

Abstract

In the research on the rabbits influence of a L-thyroxine on the activity of the protein- transporter Р-glycoprotein (Pgp) was studied. Activity of the Pgp was investigated on the pharmacokinetics of its marker substrate fexofenadine. It was established that introduction of a L-thyroxine within 14 days lead to dose-dependent rising of Рgp activity.

Keywords

MDR1 / MDR1 / L-thyroxine / hyperthyroidism / fexofenadine

References

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RIGHTS & PERMISSIONS

Yakusheva E.N., Byryukova A.S., Shchulkin A.V., Nikiforova L.V.