Pharmacokinetic of simvastatin at experimental hypothyreosis
I.P. Pavlov Russian Medical Biological Herald ›› 2011, Vol. 19 ›› Issue (4) : 38 -42.
In article data of the research devoted to studying of pharmacokinetic of simvastatin at experimental hypothyreosis are resulted. It is shown changes of pharmacokinetic parameters of main metabolite of drug – β-hydroxyacid of simvastatin, which says about decrease of bioavailability and correlation of these changes with level of T4.
β-hydroxy simvastatin / experimental hypothyroidism / the pharmacokineticparameters
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Yakusheva E.N., Popova N.M.
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