Diagnostic Significance of Proinflammatory Cytokines in Planning Dental Implantation in Patients with General Somatic Pathologies

Abstract

INTRODUCTION: The current stage of development of dental implantology permits to perform a complete dental rehabilitation even in complicated clinical situations. However, there are some difficulties which prevent achievement of a high success of implantological treatment in certain somatic pathologies that manifest in the form of systemic inflammation, and present relative contraindications for implantation. Important general somatic pathologies include chronic obstructive pulmonary disease, atherosclerosis, non-insulin-dependent diabetes mellitus, osteoporosis, etc., they are associated with the risk of acute inflammatory response of an organism to surgical implantological intervention. The risk of unpredictable complications also increases because of insufficiently wide laboratory diagnostic spectrum for planning dental implantation that includes a biochemical blood test, coagulogram, reaction to the presence of specific infections and viral diseases. This list of diagnostic data is not always sufficient for a complete prognosis of success of planned treatment in patients with a complicated general somatic or dental status. Besides, the interrelation between dental chronic diseases and general somatic pathologies which in some cases have common etiopathogenetic factors, is often not taken into account, but without the adequate diagnostic range they often remain unnoticed and lead to persistent complications in different periods after completion of treatment. Development of technologies of surgical and orthopedic dentistry permits to provide full dental care to patients even with different pathologies of organs and systems. But in this case, of importance is extended laboratory diagnostics aimed at identification of factors of chronic systemic inflammation, vascular risk, bacterial threats, for example, evaluation of some interleukins, tumor necrosis factor, C-reactive protein.

CONCLUSION: A complex of clinical, laboratory and instrumental diagnostic methods will permit to adequately evaluate risk for treatment failure and construct a prognostic tactics of complex therapy, thereby reducing the probability for unpredictable complications in dental implantation in patients with different somatic pathologies.

Keywords

dental implantation / systemic inflammation / general somatic pathology / biochemical blood test / interleukins / tumor necrosis factor / С-reactive protein

References

[1] Durnovo EA, Chekareva II, Grekhov AV, et al. Trust–Based Relationship between Patient and Doctor as Guaranty of Successful Management of Dental Implantation Complications. Nauka Molodykh (Eruditio Juvenium). 2022;10(1):91–100. (In Russ). doi: 10.23888/HMJ202210191-100

[2] Дурново Е.А., Чекарева И.И., Грехов А.В., и др. Доверительные отношения между пациентом и врачом как залог успешного лечения осложнений дентальной имплантации // Наука молодых (Eruditio Juvenium). 2022. Т. 10, № 1. С. 91–100. doi: 10.23888/HMJ202210191-100

[3] Gus’kov AV, Oleinikov AA, Domashkevich NS, et al. Possibilities and prospects for experimental and clinical instrumentation techniques for determining the primary stability of dental implants in comparative analysis. Stomatologiya. 2022;101(1):96–102. (In Russ). doi: 10.17116/stomat202210101196

[4] Гуськов А.В., Олейников А.А., Домашкевич Н.С., и др. Возможности и перспективы экспериментальных и клинических аппаратных методик определения первичной стабильности дентальных имплантатов в сравнительном анализе // Стоматология. 2022. Т. 101, № 1. С. 96–102. doi: 10.17116/stomat202210101196

[5] Pokhodenko–Chudakova IO, Karsyuk YV. Substantiation of the research on the development of the system to prognosticate dental implantation outcomes. Analytical literature review. Vestnik of Vitebsk State Medical University. 2014;13(1):6–12. (In Russ).

[6] Походенько–Чудакова И.О., Карсюк Ю.В. Обоснование исследования по разработке системы прогнозирования исходов дентальной имплантации. Аналитический обзор литературы // Вестник ВГМУ. 2014. Т. 13, № 1. С. 6–12.

[7] Velkov VV. C-reactive protein in laboratory diagnostics of acute inflammations and in risks assessments of vascular pathologies. Kliniko-laboratornyy Konsilium. 2008;(2):37–48. (In Russ).

[8] Вельков В.В. С-реактивный белок — в лабораторной диагностике острых воспалений и в оценке рисков сосудистых патологий // Клинико-лабораторный консилиум. 2008. № 2 (21). С. 37–48.

[9] Kozlova MV, Mkrtumyan AM, Belyakova AS. Regulation of bone''s metabolic process under dental implantation procedure. Kremlin Medicine Journal. 2018;(2):30–9. (In Russ).

[10] Козлова М.В., Мкртумян А.М., Белякова А.С. Регуляция метаболических процессов кости при дентальной имплантации // Кремлевская медицина. Клинический вестник. 2018. № 2. С. 30–39.

[11] Kuznetsova OA, Gubanova EI, Shemonayev VI. Tsitokiny kak pokazatel’ mestnogo immunnogo statusa patsiyentov s khronicheskim parodontitom. Lekarstvennyy Vestnik. 2013;7(2):20–5. (In Russ).

[12] Кузнецова О.А., Губанова Е.И., Шемонаев В.И. Цитокины как показатель местного иммунного статуса пациентов с хроническим пародонтитом // Лекарственный вестник. 2013. Т. 7, № 2 (50). С. 20–26.

[13] Avanesov АМ, Sedov YuG, Balashova МЕ. Pathogenesis of chronic inflammatory processes in the maxillofacial area (peri-implantitis and periodontitis) and squamous cell carcinoma: similarities and differences (review). Head and Neck Tumors. 2019;9(1):79–84. (In Russ). doi: 10.17650/2222-1468-2019-9-1-79-84

[14] Аванесов А.М., Седов Ю.Г., Балашова М.Е. Патогенез хронических воспалительных процессов в челюстно-лицевой области (периимплантита и пародонтита) и плоскоклеточного рака полости рта: сходство и различия (обзор литературы) // Опухоли головы и шеи. 2019. Т. 9, № 1. С. 79–84. doi: 10.17650/2222-1468-2019-9-1-79-84

[15] Panakhov NA, Makhmudov TG. The levels of circulating cytokines in the early post-implantation period. Kazan Medical Journal. 2017;98(6):938–43. (In Russ). doi: 10.17750/KMJ2017-938

[16] Панахов Н.А., Махмудов Т.Г. Уровни циркулирующих цитокинов в ранние сроки после периимплантационного периода // Казанский медицинский журнал. 2017. Т. 98, № 6. С. 938–943. doi: 10.17750/KMJ2017-938

[17] Rabinovich OF, Rabinovich IM, Abramova ES. The role of cytokines and immunoglobulins of the oral fluid in the genesis of autoimmune diseases of the oral mucosa. Stomatologiya. 2019;98(6, Pt 2):42–5. (In Russ). doi: 10.17116/stomat20199806242

[18] Рабинович О.Ф., Рабинович И.М., Абрамова Е.С. Роль цитокинов и иммуноглобулинов ротовой жидкости в генезе аутоиммунных заболеваний слизистой оболочки рта // Стоматология. 2019. Т. 98, № 6, Вып. 2. С. 42–45. doi: 10.17116/stomat20199806242

[19] Barnes PJ. Cellular and molecular mechanisms of chronic obstructive pulmonary disease. Clin Chest Med. 2014;35(1):71–86. doi: 10.1016/j.ccm.2013.10.004

[20] Barnes P.J. Cellular and molecular mechanisms of chronic obstructive pulmonary disease // Clin. Chest Med. 2014. Vol. 35, No. 1. P. 71–86. doi: 10.1016/j.ccm.2013.10.004

[21] Busaidi NA. Relationship between Chronic Obstructive Pulmonary Disease (COPD) and C-Reactive Protein (CRP). Madridge J. Intern Emerg Med. 2018;2(2):71–5. doi: 10.18689/mjiem-1000115

[22] Busaidi N.A. Relationship between Chronic Obstructive Pulmonary Disease (COPD) and C-Reactive Protein (CRP) // Madridge J. Intern. Emerg. Med. 2018. Vol. 2, No. 2. P. 71–75. doi: 10.18689/mjiem-1000115

[23] Logvinova OV, Poydasheva AG, Bakulin IS, et al. Modern concepts of the pathogenesis of obesity and new approaches to its correction. Obesity and Metabolism. 2018;15(2):11–6. (In Russ). doi: 10.14341/omet9491

[24] Логвинова О.В., Пойдашева А.Г., Бакулин И.С., и др. Современные представления о патогенезе ожирения и новых подходах к его коррекции // Ожирение и метаболизм. 2018. Т. 15, № 2. С. 11–16. doi: 10.14341/omet9491

[25] Kang J, Smith S, Pavitt S, et al. Association between central obesity and tooth loss in the non-obese people: Results from the continuous National Health and Nutrition Examination Survey (NHANES) 1999–2012. J Clin Periodontol. 2019;46(4):430–7. doi: 10.1111/jcpe.13091

[26] Kang J., Smith S., Pavitt S., et al. Association between central obesity and tooth loss in the non-obese people: Results from the continuous National Health and Nutrition Examination Survey (NHANES) 1999–2012 // J. Clin. Periodontol. 2019. Vol. 46, No. 4. P. 430–437. doi: 10.1111/jcpe.13091

[27] Karakov KG, Kasimova GV, Eremenko AV. The influence of components of the metabolic syndrome on the development of chronic generalized periodontitis. Parodontologiya. 2017;22(1):15–9. (In Russ).

[28] Караков К.Г., Касимова Г.В., Еременко А.В., и др. Влияние компонентов метаболического синдрома на развитие хронического генерализованного пародонтита // Пародонтология. 2017. Т. 22, № 1 (82). С. 15–19.

[29] Duzagac E, Cifcibasi E, Erdem MG, et al. Is obesity associated with healing after non-surgical periodontal therapy? A local vs. systemic evaluation. J Periodontal Res. 2016;51(5):604–12. doi: 10.1111/jre.12340

[30] Duzagac E., Cifcibasi E., Erdem M.G., et al. Is obesity associated with healing after non-surgical periodontal therapy? A local vs. systemic evaluation // J. Periodontal. Res. 2016. Vol. 51, No. 5. P. 604–612. doi: 10.1111/jre.12340

[31] Sabirova AI, Mamytova AB, Murkamilov IT, et al. The mineralization of bone tissue in patients with generalized periodontitis against the background of metabolic syndrome. Rossiiskii Meditsinskii Zhurnal. 2018;24(1):45–9. (In Russ). doi: 10.18821/0869-2106-2018-24-1-45-49

[32] Сабирова А.И., Мамытова А.Б., Муркамилов И.Т., и др. Минерализация костной ткани у больных генерализованным пародонтитом на фоне метаболического синдрома // Российский медицинский журнал. 2018. Т. 24, № 1. С. 45–49. doi: 10.18821/0869-2106-2018-24-1-45-49

[33] Astashina NB, Plyukhin DV, Sosnin YuD, et al. Salivary level of lipid peroxidation products as a predictor of dental implantation complications. Stomatologiya. 2019;98(3):31–4. (In Russ). doi: 10.17116/stomat20199803131

[34] Асташина Н.Б., Плюхин Д.В., Соснин Д.Ю., и др. Уровень перекисного окисления липидов слюны как предиктор осложнений дентальной имплантации // Стоматология. 2019. Т. 98, № 3. С. 31–34. doi: 10.17116/stomat20199803131

[35] Abduljabbar T, Al-Sahaly F, Kellesarian SV, et al. Comparison of peri-implant clinical and radiographic inflammatory parameters and whole salivary destructive inflammatory cytokine profile among obese and non-obese men. Cytokine. 2016;88:51–6. doi: 10.1016/j.cyto.2016.08.017

[36] Abduljabbar T., Al-Sahaly F., Kellesarian S.V., et al. Comparison of peri-implant clinical and radiographic inflammatory parameters and whole salivary destructive inflammatory cytokine profile among obese and non-obese men // Cytokine. 2016. Vol. 88. P. 51–56. doi: 10.1016/j.cyto.2016.08.017

[37] Monje A, Catena A, Borgnakke WS. Association between diabetes mellitus/hyperglycaemia and peri-implant diseases: Systematic review and meta-analysis. J Clin Periodontol. 2017;44(6):636–48. doi: 10.1111/jcpe.12724

[38] Monje A., Catena A., Borgnakke W.S. Association between diabetes mellitus/hyperglycaemia and peri-implant diseases: Systematic review and meta-analysis // J. Clin. Periodontol. 2017. Vol. 44, No. 6. P. 636–648. doi: 10.1111/jcpe.12724

[39] Murray CE, Coleman CM. Impact of Diabetes Mellitus on Bone Health. Int J Mol Sci. 2019;20(19):4873. doi: 10.3390/ijms20194873

[40] Murray C.E., Coleman C.M. Impact of Diabetes Mellitus on Bone Health // Int. J. Mol. Sci. 2019. Vol. 20, No. 19. P. 4873. doi: 10.3390/ijms20194873

[41] Petruk IV, Eliseeva EV, Poddubny EA, et al. Problems of anti- bacterial medications use in dental implant placement. Pacific Medical Journal. 2019;(2):51–4. (In Russ). doi: 10.17238/PmJ1609-1175.2019.2.51-54

[42] Петрук И.В., Елисеева Е.В., Поддубный Е.А., и др. Проблемы применения антибактериальных препаратов при дентальной имплантации // Тихоокеанский медицинский журнал. 2019. № 2. С. 51–54. doi: 10.17238/PmJ1609-1175.2019.2.51-54

[43] Kasimov AE, Grigorievskaya Z V, Kropotov MA, et al. Periodontal pathogens as a risk factor for oral squamous cell carcinoma. Head and Neck Tumors. 2021;11(3):83–93. (In Russ). doi: 10.17650/2222-1468-2021-11-3-83-93

[44] Казимов А.Э., Григорьевская З.В., Кропотов М.А., и др. Пародонтопатогенная микрофлора как фактор риска развития плоскоклеточного рака слизистой оболочки полости рта // Опухоли головы и шеи. 2021. Т. 11, № 3. С. 83–93. doi: 10.17650/2222-1468-2021-11-3-83-93

[45] Kharaeva ZF, Mustafaeva FM, Mustafaev MSh, et al. Interleukin’s status of patients with periimplantitis. Izvestiya Kabardino-Balkarskogo Nauchnogo Tsentra RAN. 2014;(5):254–7. (In Russ).

[46] Хараева З.Ф., Мустафаева Ф.М., Мустафаев М.Ш., и др. Интерлейкиновый статус у пациентов с периимплантитами // Известия Кабардино-Балкарского научного центра РАН. 2014. № 5 (61). С. 254–257.

[47] Grudyanov AI, Krechina EK, Tkacheva ON, et al. Vzaimosvyaz’ vospalitel’nykh zabolevaniy parodonta s serdechno-sosudistymi zabolevaniyami. Moscow; 2018. (In Russ).

[48] Грудянов А.И., Кречина Е.К., Ткачева О.Н., и др. Взаимосвязь воспалительных заболеваний пародонта с сердечно-сосудистыми заболеваниями. М.; 2018.

[49] Desvarieux M, Demmer RT, Jacobs DR Jr, et al. Periodontal bacteria and hypertension: the oral infections and vascular disease epidemiology study (INVEST). J Hypertens. 2010;28(7):1413–21. doi: 10.1097/HJH.0b013e328338cd36

[50] Desvarieux M., Demmer R.T., Jacobs D.R. Jr, et al. Periodontal bacteria and hypertension: the oral infections and vascular disease epidemiology study (INVEST) // J. Hypertens. 2010. Vol. 28, No. 7. P. 1413–1421. doi: 10.1097/HJH.0b013e328338cd36

[51] Kondyurova EV, Vlasova TI, Trofimov VA, et al. Condition of platelet factor of hemostasis system in pathogenesis of chronic periodontitis progression. I. P. Pavlov Russian Medical Biological Herald. 2019;27(2):209–18. (In Russ). doi: 10.23888/PAVLOVJ2019272209-218

[52] Кондюрова Е.В., Власова Т.И., Трофимов В.А., и др. Состояние тромбоцитарного звена системы гемостаза в патогенезе прогрессирования хронического пародонтита // Российский медико-биологический вестник имени академика И. П. Павлова. 2019. Т. 27, № 2. C. 209–218. doi: 10.23888/PAVLOVJ2019272209-218

[53] Trukhan DI, Trukhan LYu. Relationship between periodontal and cardiovascular diseases. International Heart and Vascular Disease Journal. 2016;4(11):15–24. (In Russ).

[54] Трухан Д.И., Трухан Л.Ю. Взаимоотношения болезней пародонта и сердечно-сосудистых заболеваний // Международный журнал сердца и сосудистых заболеваний. 2016. Т. 4, № 11. С. 15–24.

[55] Strelnikova EA, Trushkina PYu, Surov IYu, et al. Endothelium in vivo and in vitro. Part 1: histogenesis, structure, cytophysiology and key markers. Nauka Molodykh (Eruditio Juvenium). 2019;7(3):450–65. doi: 10.23888/HMJ201973450-465

[56] Стрельникова Е.А., Трушкина П.Ю., Суров И.Ю., и др. Эндотелий in vivo и in vitro. Часть 1: гистогенез, структура, цитофизиология и ключевые маркеры // Наука молодых (Eruditio Juvenium). 2019. Т. 7, № 3. С. 450–465. doi: 10.23888/HMJ201973450-465

[57] Kalinin RE, Suchkov IA, Klimentova EA, et al. Markers of apoptosis, cell proliferation, endothelial dysfunction in patients with peripheral atherosclerosis. Bulletin of Pirogov National Medical & Surgical Center. 2021;16(1):29–32. (In Russ). doi: 10.25881/BPNMSC.2021.26.94.005

[58] Калинин Р.Е., Сучков И.А., Климентова Э.А., и др. Маркеры апоптоза, пролиферации клеток, эндотелиальной дисфункции при атеросклерозе артерий нижних конечностей // Вестник Национального медико-хирургического центра им. Н.И. Пирогова. 2021. Т. 16, № 1. С. 29–32. doi: 10.25881/BPNMSC.2021.26.94.005

[59] Hagh LG, Zakavi F, Hajizadeh F, et al. The association between hyperlipidemia and periodontal infection. Iran Red Crescent Med J. 2014;16(12):e6577. doi: 10.5812/ircmj.6577

[60] Hagh L.G., Zakavi F., Hajizadeh F., et al. The association between hyperlipidemia and periodontal infection // Iran Red. Crescent. Med. J. 2014. Vol. 16, No. 12. P. e6577. doi: 10.5812/ircmj.6577

[61] Shetty D, Dua M, Kumar K, et al. Oral hygiene status of individuals with cardiovascular diseases and associated risk factors. Clin Pract. 2012;2(4):e86. doi: 10.4081/cp.2012.e86

[62] Shetty D., Dua M., Kumar K., et al. Oral hygiene status of individuals with cardiovascular diseases and associated risk factors // Clin. Pract. 2012. Vol. 2, No. 4. P. e86. doi: 10.4081/cp.2012.e86

[63] Yudina NA, Leus PA. New Integral Index of Dental Status and Its Use in Research. The Dental Institute. 2010;(1):86–7. (In Russ).

[64] Юдина Н.А., Леус П.А. Новый интегральный показатель стоматологического статуса и его использование в научных исследованиях // Институт Стоматологии. 2010. № 1 (46). С. 86–87.

[65] Jadon DR, Nightingale AL, McHugh NJ, et al. Serum soluble bone turnover biomarkers in psoriatic arthritis and psoriatic spondylo-arthropathy. J Rheumatol. 2015;42(1):21–30. doi: 10.3899/jrheum.140223

[66] Jadon D.R., Nightingale A.L., McHugh N.J., et al. Serum soluble bone turnover biomarkers in psoriatic arthritis and psoriatic spondyloarthropathy // J. Rheumatol. 2015. Vol. 42, No. 1. P. 21–30. doi: 10.3899/jrheum.140223

[67] Radi IAW, Ibrahim W, Iskandar SMS, et al. Prognosis of dental implants in patients with low bone density: A systematic review and meta-analysis. J Prosthet Dent. 2018;120(5):668–77. doi: 10.1016/j.prosdent.2018.01.019

[68] Radi I.A.W., Ibrahim W., Iskandar S.M.S., et al. Prognosis of dental implants in patients with low bone density: A systematic review and meta-analysis // J. Prosthet. Dent. 2018. Vol. 120, No. 5. P. 668–677. doi: 10.1016/j.prosdent.2018.01.019

[69] De Medeiros FCFL, Kudo GAH, Leme BG, et al. Dental implants in patients with osteoporosis: a systematic review with meta-analysis. Int J Oral Maxillofac Surg. 2018;47(4):480–91. doi: 10.1016/j.ijom.2017.05.021

[70] De Medeiros F.C.F.L., Kudo G.A.H., Leme B.G., et al. Dental implants in patients with osteoporosis: a systematic review with meta-analysis // Int. J. Oral Maxillofac. Surg. 2018. Vol. 47, No. 4. P. 480–491. doi: 10.1016/j.ijom.2017.05.021

[71] Durnovo EA, Fedorichev AO, Khomutinnikova NE. Modern view on the problem of oroantral fistula closure: literature review. Stomatologiya. 2019;98(2):76–80. (In Russ). doi: 10.17116/stomat20199802176

[72] Дурново Е.А., Федоричев А.О., Хомутинникова Н.Е. Современный взгляд на проблему устранения ороантральных сообщений: обзор литературы // Стоматология. 2019. Т. 98, № 2. С. 76–80. doi: 10.17116/stomat20199802176

[73] Morozova MN, Gordienko AI, Demianenko SA, et al. Dynamics of indicators of C-reactive protein and procalcitonin in the oral fluid of patients with plastic oroantral communication. Parodontologiya. 2020;25(3):246–50. (In Russ). doi: 10.33925/1683-3759-2020-25- 3-246-250

[74] Морозова М.Н., Гордиенко А.И., Демьяненко С.А., и др. Динамика показателей С-реактивного белка и прокальцитонина в ротовой жидкости пациентов с пластикой ороантрального сообщения // Пародонтология. 2020. Т. 25, № 3. С. 246–250. doi: 10.33925/1683-3759-2020-25-3-246-250

[75] Zubachik VM, Boris GZ, Furdychko AI, et al. The biochemical indices of inflammation and dysbiosis in oral fluid (saliva) of hepato-biliary pathology patients. Vestnik Stomatologii. 2017;(3):11–5. (In Russ).

[76] Зубачик В.М., Борис Г.З., Фурдычко А.И., и др. Биохимические показатели воспаления и дисбиоза в ротовой жидкости (слюне) больных гепато-билиарной патологией // Вестник стоматологии. 2017. № 3 (100). С. 11–15.

[77] Sahingur SE, Yeudall WA. Chemokine function in periodontal disease and oral cavity cancer. Front Immunol. 2015;6:214. doi: 10.3389/fimmu.2015.00214

[78] Sahingur S.E., Yeudall W.A. Chemokine function in periodontal disease and oral cavity cancer // Front. Immunol. 2015. Vol. 6. P. 214. doi: 10.3389/fimmu.2015.00214

[79] Pinchasov G, Haimov H, Druseikaite M, et al. Oral cancer around dental implants appearing in patients with\without a history of oral or systemic malignancy: a systematic review. J Oral Maxillofac Res. 2017;8(3):e1. doi: 10.5037/jomr.2017.8301

[80] Pinchasov G., Haimov H., Druseikaite M., et al. Oral cancer around dental implants appearing in patients with\without a history of oral or systemic malignancy: a systematic review // J. Oral Maxillofac. Res. 2017. Vol. 8, No. 3. P. e1. doi: 10.5037/jomr.2017.8301

[81] Oh SH, Kang JH, Seo Y–K, et al. Unusual malignant neoplasms occurring around dental implants: A report of 2 cases. Imaging Sci Dent. 2018;48(1):59–65. doi: 10.5624/isd.2018.48.1.59

[82] Oh S.H., Kang J.H., Seo Y.–K., et al. Unusual malignant neoplasms occurring around dental implants: A report of 2 cases // Imaging Sci. Dent. 2018. Vol. 48, No. 1. P. 59–65. doi: 10.5624/isd.2018.48.1.59

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