Clinical laboratory and anamnestic features of extremely premature newborns with hemodynamically significant arterial duct

Abstract

Objective. To study the clinical laboratory and anamnestic features in extremely premature newborns with hemodynamically significant functioning arterial duct.

Prematurity is an actual medical and social problem. Functioning arterial duct (FAD) is one of the most significant manifestations of cardiovascular system immaturity in extremely premature newborns.

Materials and methods. The study involved the data from 100 premature newborns (birth body mass 500 to 1500 and gestation age <32 weeks), who were born from October 2018 to April 2020 in Perm Regional Perinatal Center. According to standard EchoCG criteria, patients were divided into 2 groups: main group – patients with hemodynamically significant open arterial duct (HS FAD) and comparison group – those with insignificant FAD. All clinical laboratory studies were implemented on the third day of life.

Results. The main group included 46 extremely premature infants with hemodynamically significant FAD, the comparison group – 54 with hemodynamically insignificant FAD. Parity of labor reliably differed: 73.9 % (34/46) of mothers in the main group were primiparas and 40.7 % (22/54) in the comparison group, (p = 0.001). Pregnancy course with the threat of miscarriage was significantly more often noted in the main group – 73.9 % (34/46) of cases and 38.9 % (21/54) of cases in the comparison group, (р = 0.001). Comparative analysis of peripheral blood indices detected significant differences in thrombocytopenia, which occurred more often in the main group than in the comparison group: 52.2 % (24/46) versus 29.6 % (16/54), (p = 0.022).

Conclusions. Significant differences were established according to the parity of labor, threat of miscarriage. The threat of miscarriage reliably rises chances for giving birth to a child with HS FAD by 3.5 times, in the first labor the chance for giving birth to a child with HS FAD is increased by 4.3 times. Thrombocytopenia occurred more often in the main group versus the comparison group.

Keywords

Extremely premature newborns / functioning arterial duct / hemodynamically significant / threat of miscarriage

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RIGHTS & PERMISSIONS

Porodikov A.A.