Protein & Cell

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    2017, Vol.8  No.8

    Entero virus 71 (EV71) is a most common causative agent of hand, foot, and mouth disease (HFMD). SCARB2 is the main receptor for EV71 and critical for both viral infection and pathogenesis. In this issue, Zhang and colleagues generated a monoclonal antibody JL2, which binds human but not mouse SCARB2 and blocks EV71 infection effectively. Structural views of SCARB2-JL2 complex reveal that JL2 binds to the apical region of SCARB2 involving α-helices 2, 5, a [Detail] ...

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ISSN 1674-800X (Print)
ISSN 1674-8018 (Online)
2016 Impact Factor: 5.374

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