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Frontiers of Optoelectronics

Front. Optoelectron.    2018, Vol. 11 Issue (1) : 23-29     https://doi.org/10.1007/s12200-018-0759-3
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Recent advances in photonic dosimeters for medical radiation therapy
James ARCHER, Enbang LI()
Centre for Medical Radiation Physics, University of Wollongong, Wollongong NSW 2522, Australia
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Abstract

Radiation therapy, which uses X-rays to destroy or injure cancer cells, has become one of the most important modalities to treat the primary cancer or advanced cancer. High resolution, water equivalent and passive X-ray dosimeters are highly desirable for developing quality assurance (QA) systems for novel cancer therapy like microbeam radiation therapy (MRT) which is currently under development. Here we present the latest developments of high spatial resolution scintillator based photonic dosimeters, and their applications to clinical external radiation beam therapies: specifically high energy linear accelerator (LINAC) photon beams and low energy synchrotron photon beams. We have developed optical fiber dosimeters with spatial resolutions ranging from 50 to 500 mm and tested them with LINAC beams and synchrotron microbeams. For LINAC beams, the fiber-optic probes were exposed to a 6 MV, 10 cm by 10 cm X-ray field and, the beam profiles as well as the depth dose profiles were measured at a source-to-surface distance (SSD) of 100 cm. We have also demonstrated the possibility for temporally separating Cherenkov light from the pulsed LINAC scintillation signals. Using the 50 mm fiber probes, we have successfully resolved the microstructures of the microbeams generated by the imaging and medical beamline (IMBL) at the Australian Synchrotron and measured the peak-to-valley dose ratios (PVDRs). In this paper, we summarize the results we have achieved so far, and discuss the possible solutions to the issues and challenges we have faced, also highlight the future work to further enhance the performances of the photonic dosimeters.

Keywords fiber-optic dosimetry      scintillators      X-ray      Cherenkov radiation      cancer therapy      microbeam radiation therapy (MRT)     
Corresponding Authors: Enbang LI   
Online First Date: 26 February 2018    Issue Date: 02 April 2018
 Cite this article:   
James ARCHER,Enbang LI. Recent advances in photonic dosimeters for medical radiation therapy[J]. Front. Optoelectron., 2018, 11(1): 23-29.
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http://journal.hep.com.cn/foe/EN/10.1007/s12200-018-0759-3
http://journal.hep.com.cn/foe/EN/Y2018/V11/I1/23
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James ARCHER
Enbang LI
Fig.1  Diagram of the dosimeter probe. Figure modified from Archer et al. [29]
Fig.2  (a) CLINAC beam profile measured with the fiber optic dosimeter probe (FOD), compared to ionization chamber data. Reproduced from Archer et al. [29]. Temporal separation results are shown in (b)
Fig.3  (a) Percent depth dose of the CLINAC beam measured with the fiber optic dosimeter probe (FOD), compared to ionization chamber data. Reproduced from Archer et al. [29]. Temporal separation results are show in (b)
Fig.4  Microbeam profile measured with (a) 50 mm probe and (b) SSD. Insets show the same three microbeams in closer detail. Reproduced from Archer et al. [31]
Fig.5  Percent depth dose plots, measured with the fiber optic dosimeter (FOD) at scanning speeds of (a) 10 mm/s and (b) 5 mm/s. Ionization chamber (IC) results are also shown. Reproduced from Archer et al. [31]
Fig.6  Intrinsic microbeam field (measures with a 1 μm resolution SCDD) in blue, the convolution of this field with a 50 μm rectangular window in orange, and the experimental data of the central microbeam in green
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