Please wait a minute...

Frontiers of Optoelectronics

Front. Optoelectron.    2018, Vol. 11 Issue (1) : 23-29
Recent advances in photonic dosimeters for medical radiation therapy
James ARCHER, Enbang LI()
Centre for Medical Radiation Physics, University of Wollongong, Wollongong NSW 2522, Australia
Download: PDF(324 KB)   HTML
Export: BibTeX | EndNote | Reference Manager | ProCite | RefWorks

Radiation therapy, which uses X-rays to destroy or injure cancer cells, has become one of the most important modalities to treat the primary cancer or advanced cancer. High resolution, water equivalent and passive X-ray dosimeters are highly desirable for developing quality assurance (QA) systems for novel cancer therapy like microbeam radiation therapy (MRT) which is currently under development. Here we present the latest developments of high spatial resolution scintillator based photonic dosimeters, and their applications to clinical external radiation beam therapies: specifically high energy linear accelerator (LINAC) photon beams and low energy synchrotron photon beams. We have developed optical fiber dosimeters with spatial resolutions ranging from 50 to 500 mm and tested them with LINAC beams and synchrotron microbeams. For LINAC beams, the fiber-optic probes were exposed to a 6 MV, 10 cm by 10 cm X-ray field and, the beam profiles as well as the depth dose profiles were measured at a source-to-surface distance (SSD) of 100 cm. We have also demonstrated the possibility for temporally separating Cherenkov light from the pulsed LINAC scintillation signals. Using the 50 mm fiber probes, we have successfully resolved the microstructures of the microbeams generated by the imaging and medical beamline (IMBL) at the Australian Synchrotron and measured the peak-to-valley dose ratios (PVDRs). In this paper, we summarize the results we have achieved so far, and discuss the possible solutions to the issues and challenges we have faced, also highlight the future work to further enhance the performances of the photonic dosimeters.

Keywords fiber-optic dosimetry      scintillators      X-ray      Cherenkov radiation      cancer therapy      microbeam radiation therapy (MRT)     
Corresponding Authors: Enbang LI   
Online First Date: 26 February 2018    Issue Date: 02 April 2018
 Cite this article:   
James ARCHER,Enbang LI. Recent advances in photonic dosimeters for medical radiation therapy[J]. Front. Optoelectron., 2018, 11(1): 23-29.
E-mail this article
E-mail Alert
Articles by authors
Enbang LI
Fig.1  Diagram of the dosimeter probe. Figure modified from Archer et al. [29]
Fig.2  (a) CLINAC beam profile measured with the fiber optic dosimeter probe (FOD), compared to ionization chamber data. Reproduced from Archer et al. [29]. Temporal separation results are shown in (b)
Fig.3  (a) Percent depth dose of the CLINAC beam measured with the fiber optic dosimeter probe (FOD), compared to ionization chamber data. Reproduced from Archer et al. [29]. Temporal separation results are show in (b)
Fig.4  Microbeam profile measured with (a) 50 mm probe and (b) SSD. Insets show the same three microbeams in closer detail. Reproduced from Archer et al. [31]
Fig.5  Percent depth dose plots, measured with the fiber optic dosimeter (FOD) at scanning speeds of (a) 10 mm/s and (b) 5 mm/s. Ionization chamber (IC) results are also shown. Reproduced from Archer et al. [31]
Fig.6  Intrinsic microbeam field (measures with a 1 μm resolution SCDD) in blue, the convolution of this field with a 50 μm rectangular window in orange, and the experimental data of the central microbeam in green
1 Leo W R. Techniques for Nuclear and Particle Physics. Berlin Heidelberg: Springer, 1994
2 Čerenkov P A. Visible radiation produced by electrons moving in a medium with velocities exceeding that of light. Physical Review, 1937, 52(4): 378–379
3 O’Keeffe S, McCarthy D, Woulfe P, Grattan M W D, Hounsell A R, Sporea D, Mihai L, Vata I, Leen G, Lewis E. A review of recent advances in optical fibre sensors for in vivo dosimetry during radiotherapy. The British Journal of Radiology, 2015, 88(1050): 20140702 pmid: 25761212
4 Aberle C, Elagin A, Frisch H J, Wetstein M, Winslow L. Measuring directionality in double-beta decay and neutrino interactions with kiloton-scale scintillation detectors. Journal of Instrumentation, 2014, 9: P06012
5 Rusby D R, Brenner C M, Armstrong C, Wilson L A, Clarke R, Alejo A, Ahmed H, Butler N M H, Haddock D, Higginson A, McClymont A, Mirfayzi S R, Murphy C, Notley M, Oliver P, Allott R, Hernandez-Gomez C, Kar S, McKenna P, Neely D. Pulsed X-ray imaging of high-density objects using a ten picosecond high-intensity laser driver. In: Proceedings of Emerging Imaging & Sensing Technologies. 2016, 9992: 99920E
6 Deas R M, Wilson L A, Rusby D, Alejo A, Allott R, Black P P, Black S E, Borghesi M, Brenner C M, Bryant J, Clarke R J, Collier J C, Edwards B, Foster P, Greenhalgh J, Hernandez-Gomez C, Kar S, Lockley D, Moss R M, Najmudin Z, Pattathil R, Symes D, Whittle M D, Wood J C, McKenna P, Neely D. A laser driven pulsed X-ray backscatter technique for enhanced penetrative imaging. Journal of X-Ray Science and Technology, 2015, 23(6): 791–797 pmid: 26756414
7 Beddar A S, Mackie T R, Attix F H. Water-equivalent plastic scintillation detectors for high-energy beam dosimetry: 1. physical characteristics and theoretical considerations. Physics in Medicine & Biology, 1992, 37(10): 1883–1900
8 Beddar A S, Mackie T R, Attix F H. Water-equivalent plastic scintillation detectors for high-energy beam dosimetry: 2. properties and measurements. Physics in Medicine & Biology, 1992, 37(10): 1901–1913
9 Beaulieu L, Beddar S. Review of plastic and liquid scintillation dosimetry for photon, electron, and proton therapy. Physics in Medicine & Biology, 2016, 61(20): R305
10 Shaffer T M, Pratt E C, Grimm J. Utilizing the power of Cerenkov light with nanotechnology. Nature Nanotechnology, 2017, 12(2): 106
11 Andreozzi J M, Zhang R, Gladstone D J, Williams B B, Glaser A K, Pogue B W, Jarvis L A. Cherenkov imaging method for rapid optimization of clinical treatment geometry in total skin electron beam therapy. Medical Physics, 2016, 43(2): 993–1002
12 Vukolov A V, Novokshonov A I, Potylitsyn A P, Uglov S R. Electron beam diagnostics tool based on Cherenkov radiation in optical fibers. Journal of Physics Conference Series,  2016,  732 (1): 012011
13 Boer S F D, Beddar A S, Rawlinson J A. Optical filtering and spectral measurements of radiation-induced light in plastic scintillation dosimetry. Physics in Medicine & Biology, 1993, 38(7): 945–958
14 Clift M A, Sutton R A, Webb D V. Dealing with Cerenkov radiation generated in organic scintillator dosimeters by bremsstrahlung beams. Physics in Medicine & Biology, 2000, 45(5): 1165–1182
15 Archambault L, Therriault-Proulx F, Beddar S, Beaulieu L. A mathematical formalism for hyperspectral, multipoint plastic scintillation detectors. Physics in Medicine & Biology,  2012,  57 (21): 7133–7145
16 Therriault-Proulx F, Archambault L, Beaulieu L, Beddar S. Development of a novel multi-point plastic scintillation detector with a single optical transmission line for radiation dose measurement. Physics in Medicine & Biology, 2012, 57(21): 7147–7159
17 Clift M A, Johnston P N, Webb D V. A temporal method of avoiding the Cerenkov radiation generated in organic scintillator dosimeters by pulsed mega-voltage electron and photon beams. Physics in Medicine & Biology, 2002, 47(8): 1421–1433
18 Justus B L, Falkenstein P, Huston A L, Plazas M C, Ning H, Miller R W. Gated fiber-optic-coupled detector for in vivo real-time radiation dosimetry. Applied Optics, 2004, 43(8): 1663–1668 pmid: 15046169
19 Bouchet A, Lemasson B, Christen T, Potez M, Rome C, Coquery N, Le Clec'h C, Moisan A, Brauer-Krisch E, Leduc G, Remy C, Laissue J A, Barbier E L, Brun E, Serduc R. Synchrotron microbeam radiation therapy induces hypoxia in intracerebral gliosarcoma but not in the normal brain. Radiotherapy and Oncology, 2013, 108(1): 143–148
20 Crosbie J C, Anderson R L, Rothkamm K, Restall C M, Cann L, Ruwanpura S, Meachem S, Yagi N, Svalbe I, Lewis R A, Williams B R, Rogers P A. Tumor cell response to synchrotron microbeam radiation therapy differs markedly from cells in normal tissues. International Journal of Radiation Oncology, Biology, Physics, 2010, 77(3): 886–894
21 Regnard P, Le Duc G, Brauer-Krisch E, Clair C, Kusak A, Dallery D, et al.. Microbeam radiation therapy (MRT) applied to rats ́brain tumor: finding the best compromise between normal tissue sparing and tumor curing. European Journal of Cancer Supplements, 2005, 3(2): 396
22 Serduc R, Vérant P, Vial J C, Farion R, Rocas L, Rémy C, Fadlallah T, Brauer E, Bravin A, Laissue J, Blattmann H, van der Sanden B. In vivo two-photon microscopy study of short-term effects of microbeam irradiation on normal mouse brain microvasculature. International Journal of Radiation Oncology, Biology, Physics, 2006, 64(5): 1519–1527 pmid: 16580502
23 Smyth L M L, Senthi S, Crosbie J C, Rogers P A W. The normal tissue effects of microbeam radiotherapy: what do we know, and what do we need to know to plan a human clinical trial? International Journal of Radiation Biology, 2016, 92(6): 302–311 pmid: 26982077
24 Cornelius I, Guatelli S, Fournier P, Crosbie J C, Sanchez Del Rio M, Bräuer-Krisch E, Rosenfeld A, Lerch M. Benchmarking and validation of a Geant4-SHADOW Monte Carlo simulation for dose calculations in microbeam radiation therapy. Journal of Synchrotron Radiation, 2014, 21(3): 518–528 pmid: 24763641
25 Fournier P, Cornelius I, Donzelli M, Requardt H, Nemoz C, Petasecca M, Bräuer-Krisch E, Rosenfeld A, Lerch M. X-Tream quality assurance in synchrotron X-ray microbeam radiation therapy. Journal of Synchrotron Radiation, 2016, 23(5): 1180–1190 pmid: 27577773
26 Fournier P, Cornelius I, Dipuglia A, Cameron M, Davis J A, Cullen A, Petasecca M, Rosenfeld A B, Brauer-Krisch E, Häusermann D, Stevenson A W, Perevertaylo V, Lerch M L F. X-Tream dosimetry of highly brilliant X-ray microbeams in the MRT hutch of the Australian Synchrotron. Radiation Measurements, 2017 doi: 10.1016/j.radmeas.2017.01.011
27 Lerch M L F, Dipuglia A, Cameron M, Fournier P, Davis J, Petasecca M, CorneliusI,  Perevertaylo V,  RosenfeldA B. New 3D silicon detectors for dosimetry in Microbeam Radiation Therapy. Journal of Physics Conference Series, 2017, 777(1): 012009
28 Belley M D, Stanton I N, Hadsell M, Ger R, Langloss B W, Lu J, Zhou O, Chang S X, Therien M J, Yoshizumi T T. Fiber-optic detector for real time dosimetry of a micro-planar X-ray beam. Medical Physics, 2015, 42(4): 1966–1972 pmid: 25832087
29 Archer J, Li E, Petasecca M, Lerch M, Rosenfeld A, Carolan M. High-resolution fiber-optic dosimeters for microbeam radiation therapy. Medical Physics, 2017, 44(5): 1965–1968 pmid: 28294350
30 Archer J, Madden L, Li E, Carolan M, Petasecca M, Metcalfe P, Rosenfeld A. Temporally separating Cherenkov radiation in a scintillator probe exposed to a pulsed X-ray beam. Physica Medica, 2017, 42: 185–188
Related articles from Frontiers Journals
[1] Kun LI,Weiwei QIN,Yan XU,Tianhuan PENG,Di LI. Optical approaches in study of nanocatalysis with single-molecule and single-particle resolution[J]. Front. Optoelectron., 2015, 8(4): 379-393.
[2] Tongfu SU, Bin YU, Pengyu HAN, Guozhong ZHAO, Changrong GONG. Characterization of spectra of lignin from midribs of tobacco at THz frequencies[J]. Front Optoelec Chin, 2009, 2(3): 244-247.
Full text