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Frontiers in Biology

Front. Biol.    2018, Vol. 13 Issue (6) : 406-417
Association of mitochondrial dysfunction and lipid metabolism with type 2 diabetes mellitus: A review of literature
Karimeh Haghani1, Pouyan Asadi2, Gholamreza Taheripak3, Ali Noori-Zadeh4, Shahram Darabi5, Salar Bakhtiyari1()
1. Department of Clinical Biochemistry, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran
2. Medical Cellular & Molecular Research Center, Golestan University of Medical Sciences, Gorgan, Iran
3. Department of Clinical Biochemistry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
4. Department of Clinical Biochemistry, Faculty of Paramedicine, Ilam University of Medical Sciences, Ilam, Iran
5. Cellular and Molecular Research Center, Qazvin University of Medical Science, Qazvin, Iran
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BACKGROUND: Diabetes mellitus (DM) is one of the most prevalent chronic diseases, and its prevalence continues to increase globally. The impact of mitochondrial dysfunction and lipid metabolism on diabetes mellitus and insulin resistance (IR) has been implicated in several previous reports; however, the results of studies are confusing despite four decades of study.

METHODS/RESULTS: This review has evaluated updated understanding of the role of mitochondrial dysfunction and lipid metabolism on type 2 diabetes, and found that mitochondrial dysfunction and lipid metabolism disorder induce the dysregulation of liver and pancreatic beta cells, insulin resistance, and type 2 diabetes.

CONCLUSION: Mitochondrial dysfunction and lipid metabolism induce metabolic dysregulation and finally increasing the possibility of diabetes.

Keywords Insulin resistance      Type 2 diabetes      Mitochondrial dysfunction      Lipid metabolism     
Corresponding Author(s): Salar Bakhtiyari   
Online First Date: 26 October 2018    Issue Date: 30 November 2018
 Cite this article:   
Karimeh Haghani,Pouyan Asadi,Gholamreza Taheripak, et al. Association of mitochondrial dysfunction and lipid metabolism with type 2 diabetes mellitus: A review of literature[J]. Front. Biol., 2018, 13(6): 406-417.
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Karimeh Haghani
Pouyan Asadi
Gholamreza Taheripak
Ali Noori-Zadeh
Shahram Darabi
Salar Bakhtiyari
Fig.1  Diabetes mellitus pathogenesis. This disease has many pathogenesis aspects. In this literature, the association of mitochondrial dysfunction and lipid metabolism with diabetes have been reviewed.
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