Intracardiac echocardiography in the diagnosis and treatment of atrial fibrillation

Jiongchao Guo , Xu Liu , Minglong Chen , Yumin Sun , Xiaofeng Hu

Vessel Plus ›› 2026, Vol. 10 ›› Issue (1) : 40

PDF
Vessel Plus ›› 2026, Vol. 10 ›› Issue (1) :40 DOI: 10.20517/2574-1209.2025.171
Review
Intracardiac echocardiography in the diagnosis and treatment of atrial fibrillation
Author information +
History +
PDF

Abstract

Intracardiac echocardiography (ICE) has become an indispensable real-time imaging modality in atrial fibrillation (AF) ablation procedures, offering distinct advantages across multiple domains, including pre-procedural exclusion of left atrial appendage (LAA) thrombus, real-time guidance for transseptal puncture, catheter localization during ablation, anatomical assessment for LAA closure, and monitoring of complications such as pericardial effusion. Recent investigations have further expanded its utility, particularly in pre-ablation LAA thrombus screening and in guiding emerging pulsed-field ablation techniques. Beyond procedural navigation, ICE enables early detection and timely management of potentially serious complications, while also substantially reducing radiation exposure during transseptal puncture. This review provides a comprehensive overview of the broadening applications of ICE in AF catheter ablation and related interventions, with a specific focus on its current roles in AF ablation and LAA occlusion. The synthesized evidence offers a valuable framework for optimizing future clinical strategies that integrate ICE into AF diagnosis and treatment. Given its considerable benefits in enhancing both safety and efficacy, the broader adoption of ICE in these procedures is strongly warranted.

Keywords

Intracardiac echocardiography / atrial fibrillation / transseptal puncture / left atrial appendage / ablation

Cite this article

Download citation ▾
Jiongchao Guo, Xu Liu, Minglong Chen, Yumin Sun, Xiaofeng Hu. Intracardiac echocardiography in the diagnosis and treatment of atrial fibrillation. Vessel Plus, 2026, 10 (1) : 40 DOI:10.20517/2574-1209.2025.171

登录浏览全文

4963

注册一个新账户 忘记密码

References

[1]

Marrouche NF,Andresen D.Catheter ablation for atrial fibrillation with heart failure.N Engl J Med2018;378:417-27

[2]

Van Gelder IC,Bunting KV.2024 ESC Guidelines for the management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS).Eur Heart J2024;45:3314-414

[3]

Joglar JA,Armbruster AL.2023 ACC/AHA/ACCP/HRS guideline for the diagnosis and management of atrial fibrillation: a report of the American College of Cardiology/American Heart Association Joint Committee on clinical practice guidelines.Circulation2024;149:e1-e156

[4]

Reddy VY,Halperin J.Percutaneous left atrial appendage closure vs warfarin for atrial fibrillation: a randomized clinical trial.JAMA2014;312:1988

[5]

Wazni OM,Nair DG.Left atrial appendage closure after ablation for atrial fibrillation.N Engl J Med2025;392:1277-87

[6]

Holmes DR,Price MJ.Prospective randomized evaluation of the watchman left atrial appendage closure device in patients with atrial fibrillation versus long-term warfarin therapy.J Am Coll Cardiol2014;64:1-12

[7]

Tzikas A,Gafoor S.Left atrial appendage occlusion for stroke prevention in atrial fibrillation: multicentre experience with the AMPLATZER cardiac plug.EuroIntervention2016;11:1170-9

[8]

Sousonis V,Vavouris E,Ypsilanti E.The use of intracardiac echocardiography in catheter ablation of atrial fibrillation.Curr Cardiol Rep2024;26:893-901

[9]

Lin D.Use of intracardiac echocardiography during atrial fibrillation ablation to avoid complications.Future Cardiol2015;11:683-7

[10]

Luani B.A practical guide and review of the literature on zero-fluoroscopy electrophysiology catheter navigation by intracardiac echocardiography.Int J Cardiovasc Imaging2024;41:397-407

[11]

Alyesh D,Demo H,Sundaram S.The advanced application of intracardiac echocardiography for cardiac electrophysiology ablation procedures.Curr Cardiol Rep2022;24:505-11

[12]

Kautzner J,Lehar F.Intracardiac echocardiography to guide non-fluoroscopic electrophysiology procedures.Cardiac Electrophysiol Clin2021;13:399-408

[13]

Enriquez A,Rosso R.Use of intracardiac echocardiography in interventional cardiology: working with the anatomy rather than fighting it.Circulation2018;137:2278-94

[14]

Garg J,Bhardwaj R,Jain S.Intracardiac echocardiography from coronary sinus.J Cardiovasc Electrophysiol2022;33:2382-8 PMCID:PMC9828028

[15]

Morton JB,Sparks PB,Kalman JM.Usefulness of phased-array intracardiac echocardiography for the assessment of left atrial mechanical “stunning” in atrial flutter and comparison with multiplane transesophageal echocardiography.Am J Cardiol2002;90:741-6

[16]

Blendea D,Danik SB,Ruskin JN.Analysis of the left atrial appendage morphology by intracardiac echocardiography in patients with atrial fibrillation.J Interv Card Electrophysiol2011;31:191-6

[17]

Sriram CS,Moukabary T,Gonzalez MD.Detection of left atrial thrombus by intracardiac echocardiography in patients undergoing ablation of atrial fibrillation.J Interv Card Electrophysiol2015;43:227-36

[18]

Tsyganov A,Sandrikov V.Transesophageal vs. intracardiac echocardiographic screening in patients undergoing atrial fibrillation ablation with uninterrupted rivaroxaban.BMC Cardiovasc Disord2017;17:171

[19]

Baran J,Pilichowska-Paszkiet E.Intracardiac echocardiography for detection of thrombus in the left atrial appendage: comparison with transesophageal echocardiography in patients undergoing ablation for atrial fibrillation: the action-ice I study.Circ Arrhythm Electrophysiol2013;6:1074-81

[20]

Nishiyama T,Inagawa K.Visualization of the left atrial appendage by phased-array intracardiac echocardiography from the pulmonary artery in patients with atrial fibrillation.Europace2015;17:546-51

[21]

Saksena S,Jordaens L.A prospective comparison of cardiac imaging using intracardiac echocardiography with transesophageal echocardiography in patients with atrial fibrillation: the intracardiac echocardiography guided cardioversion helps interventional procedures study.Circ Arrhythm Electrophysiol2010;3:571-7

[22]

Ren JF,Supple GE.Intracardiac echocardiographic diagnosis of thrombus formation in the left atrial appendage: a complementary role to transesophageal echocardiography.Echocardiography2012;30:72-80

[23]

Anter E,Tschabrunn CM.Comparison of intracardiac echocardiography and transesophageal echocardiography for imaging of the right and left atrial appendages.Heart Rhythm2014;11:1890-7

[24]

Wang Y,Zhou K.Intracardiac echocardiography is a safe and effective alternative to transesophageal echocardiography for left atrial appendage thrombus evaluation at the time of atrial fibrillation ablation: the ICE-TEE study.Pacing Clin Electrophysiol2022;46:3-10

[25]

Hu X,Wang X.Intracardiac vs transesophageal echocardiography in atrial fibrillation ablation: a randomized clinical trial.JAMA Cardiol2025;10:1249 PMCID:PMC12509080

[26]

Tzeis S,Deisenhofer I,Theodorakis G.Transseptal catheterization: considerations and caveats.Pacing Clin Electrophysiol2010;33:231-42

[27]

Rosu R,Muresan L.Intracardiac echocardiography for transseptal puncture. A guide for cardiac electrophysiologists.Med Ultrason2019;21:183

[28]

Razminia M,Eryazici PL.Nonfluoroscopic catheter ablation of cardiac arrhythmias in adults: feasibility, safety, and efficacy.J Cardiovasc Electrophysiol2012;23:1078-86

[29]

Santangeli P,Burkhardt JD.Transseptal access and atrial fibrillation ablation guided by intracardiac echocardiography in patients with atrial septal closure devices.Heart Rhythm2011;8:1669-75

[30]

Lakkireddy D,Prasad S.Intracardiac echo-guided radiofrequency catheter ablation of atrial fibrillation in patients with atrial septal defect or patent foramen ovale repair: a feasibility, safety, and efficacy study.J Cardiovasc Electrophysiol2008;19:1137-42

[31]

Bottoni N,Rossi L.Impact of systematic use of intracardiac ultrasound during transseptal catheterization in the electrophysiology laboratory.J Cardiovasc Dev Dis2023;10:62 PMCID:PMC9960297

[32]

Aldhoon B,Peichl P,Kautzner J.Complications of catheter ablation for atrial fibrillation in a high-volume centre with the use of intracardiac echocardiography.EP Eur2013;15:24-32

[33]

Bhatia NL,Chandrasekaran K.Atrial fibrillation ablation in cor triatriatum: value of intracardiac echocardiography.J Interv Card Electrophysiol2009;28:153-5

[34]

Karimianpour A,Cuoco FA,Litwin SE.Catheter ablation of atrial fibrillation in patients with cor triatriatum sinister; case series and review of literature.Pacing Clin Electrophysiol2021;44:2084-91

[35]

Pantano A.Fluoroless catheter ablation of atrial fibrillation: integration of intracardiac echocardiography and cartosound module.J Atr Fibrillation2021;14:20200477 PMCID:PMC8691270

[36]

Jan M,Kuhelj D.Combined use of electro-anatomic mapping system and intracardiac echocardiography to achieve zero-fluoroscopy catheter ablation for treatment of paroxysmal atrial fibrillation: a single centre experience.Int J Cardiovasc Imaging2019;36:415-22

[37]

Wang Y,Xiao F.Multicenter practice of non/minimized fluoroscopy ablation for paroxysmal AF in China.JACC Asia2025;5:1540-8 PMCID:PMC12794002

[38]

Verma A,Natale A.Pulmonary vein antrum isolation: intracardiac echocardiography-guided technique.J Cardiovasc Electrophysiol2004;15:1335-40

[39]

Bunch TJ,Crandall BG.Intracardiac ultrasound for esophageal anatomic assessment and localization during left atrial ablation for atrial fibrillation.J Cardiovasc Electrophysiol2012;24:33-9

[40]

Olgin JE,Chin M.Electrophysiological effects of long, linear atrial lesions placed under intracardiac ultrasound guidance.Circulation1997;96:2715-21

[41]

Jackson LR,Parish A,Piccini JP.Safety of continuous left atrial phased-array intracardiac echocardiography during left atrial ablation for atrial fibrillation.Heart Rhythm O22022;3:673-80 PMCID:PMC9795249

[42]

Motoike Y,Ito T.Wall thickness-based adjustment of ablation index improves efficacy of pulmonary vein isolation in atrial fibrillation: Real-time assessment by intracardiac echocardiography.J Cardiovasc Electrophysiol2021;32:1620-30

[43]

Xu J,Liu C.Radiofrequency ablation for treatment of atrial fibrillation with the use of intracardiac echocardiography versus without intracardiac echocardiography: a meta-analysis of observational and randomized studies.J Cardiovasc Electrophysiol2022;33:897-907

[44]

Goya M,Gache L.The use of intracardiac echocardiography catheters in endocardial ablation of cardiac arrhythmia: meta-analysis of efficiency, effectiveness, and safety outcomes.J Cardiovasc Electrophysiol2020;31:664-73 PMCID:PMC7078927

[45]

NÖlker G,Gutleben KJ.Cryoballoon pulmonary vein isolation supported by intracardiac echocardiography: integration of a nonfluoroscopic imaging technique in atrial fibrillation ablation.J Cardiovasc Electrophysiol2010;21:1325-30

[46]

Makino Y,Yamashita D.Cryoballoon ablation for atrial fibrillation without the use of a contrast medium: a combination of the intracardiac echocardiography and pressure wave monitoring guided approach.Heart Vessels2021;37:765-74

[47]

Catanzariti D,Angheben C,Cemin C.Usefulness of contrast intracardiac echocardiography in performing pulmonary vein balloon occlusion during cryo-ablation for atrial fibrillation.Ind Pacing Electrophysiol J2012;12:237-49 PMCID:PMC3513238

[48]

Schmidt M,Marschang H.Intracardiac echocardiography improves procedural efficiency during cryoballoon ablation for atrial fibrillation: a pilot study.J Cardiovasc Electrophysiol2010;21:1202-7

[49]

Pongratz J,Wu L.Impact of intracardiac echocardiography usage on the safety of cryoballoon atrial fibrillation ablation: suban alysis of the prospective FREEZE cluster cohort study.J Cardiovasc Electrophysiol2023;34:2029-39

[50]

Ahn J,Han S.Safety and efficacy of intracardiac echocardiography-guided zero-fluoroscopic cryoballoon ablation for atrial fibrillation: a prospective randomized controlled trial.Europace2023;25:euad086 PMCID:PMC10228535

[51]

Lakhani M,Bekheit S.Use of intracardiac echocardiography for early detection of phrenic nerve injury during cryoballoon pulmonary vein isolation.J Cardiovasc Electrophysiol2012;23:874-6

[52]

Howard B,Tzou WS.Effects of electrode-tissue proximity on cardiac lesion formation using pulsed field ablation.Circ Arrhythm Electrophysiol2022;15:e011110 PMCID:PMC9584049

[53]

Mattison L,Tarakji KG.Effect of contact force on pulsed field ablation lesions in porcine cardiac tissue.J Cardiovasc Electrophysiol2023;34:693-9

[54]

Nakagawa H,Neal R.Effects of contact force on lesion size during pulsed field catheter ablation: histochemical characterization of ventricular lesion boundaries.Circ Arrhythm Electrophysiol2024;17:e012026

[55]

Rauber M,Eberl AS.Zero-fluoroscopy ablation with multielectrode pulse field ablation system: case series.Pacing Clin Electrophysiol2023;47:117-20

[56]

Dello Russo A,Schillaci V.Intracardiac echocardiography-guided pulsed-field ablation for successful ablation of atrial fibrillation: a propensity-matched analysis from a large nationwide multicenter experience.J Interv Card Electrophysiol2023;67:1257-66

[57]

Daimee UA,Masoudi FA.Indications for left atrial appendage occlusion in the united states and associated in-hospital outcomes: results from the NCDR LAAO registry.Circ Cardiovasc Qual Outcomes2022;15:e008418 PMCID:PMC9388561

[58]

Korsholm K,Nielsen-Kudsk JE.Intracardiac echocardiography from the left atrium for procedural guidance of transcatheter left atrial appendage occlusion.JACC Cardiovasc Interv2017;10:2198-206

[59]

Gianni C,Della Rocca DG.Intracardiac echocardiography- versus transesophageal echocardiography-guided left atrial appendage occlusion with Watchman FLX.J Cardiovasc Electrophysiol2021;32:2781-4

[60]

Berti S,Meucci F.Periprocedural intracardiac echocardiography for left atrial appendage closure.JACC Cardiovasc Interv2014;7:1036-44

[61]

Matsuo Y,Petru J.Left atrial appendage closure under intracardiac echocardiographic guidance: feasibility and comparison with transesophageal echocardiography.J Am Heart Assoc2016;5:e003695 PMCID:PMC5121476

[62]

Ayhan H,Gedikli Ö.A simple method to detect leaks after left atrial appendage occlusion with Watchman.J Cardiovasc Electrophysiol2020;31:2338-43

[63]

Della Rocca DG,Gianni C.Three-dimensional intracardiac echocardiography for left atrial appendage sizing and percutaneous occlusion guidance.Europace2024;26:euae010

[64]

Serpa F,Fernandes JM.Intracardiac vs transesophageal echocardiography for left atrial appendage occlusion: an updated systematic review and meta-analysis.Heart Rhythm2025;22:786-95

[65]

Sularz A,Al-Abcha A.Safety and feasibility of 3D intracardiac echocardiography in guiding left atrial appendage occlusion with WATCHMAN FLX.JACC Adv2025;4:101570 PMCID:PMC11782859

[66]

Pimentel RC,Maccioni S.Differences in outcomes among patients with atrial fibrillation undergoing catheter ablation with versus without intracardiac echocardiography.J Cardiovasc Electrophysiol2022;33:2015-47 PMCID:PMC9544828

[67]

Miller JD,Spragg DD.First report of dabigatran reversal in iatrogenic pericardial tamponade during catheter ablation of atrial fibrillation.HeartRhythm Case Rep2017;3:566-7 PMCID:PMC5741803

[68]

Ren J,Callans DJ.Left atrial thrombus associated with ablation for atrial fibrillation: identification with intracardiac echocardiography.J Am Coll Cardiol2004;43:1861-7

[69]

Maleki K,Hart D,Farhat N.Intracardiac ultrasound detection of thrombus on transseptal sheath: incidence, treatment, and prevention.J Cardiovasc Electrophysiol2005;16:561-5

[70]

Liu X,Peng X.Visualization and mapping of the right phrenic nerve by intracardiac echocardiography during atrial fibrillation ablation.EP Europace2023;25:1352-60 PMCID:PMC10105843

[71]

Lakkireddy D.ICE-derived left atrial and left ventricular endocardial and myocardial speckle tracking strain patterns in atrial fibrillation at the time of radiofrequency ablation.J Atr Fibrillation2021;13:2509 PMCID:PMC8691347

[72]

Sharma A,Tholakanahalli V,Chandrashekhar Y.4D intracardiac echocardiography-guided LA appendage closure under conscious sedation.JACC Cardiovasc Imaging2021;14:2254-9

[73]

Ranard LS,Donald E.Transcatheter left atrial appendage closure using preprocedural computed tomography and intraprocedural 4-dimensional intracardiac echocardiography.Circ Cardiovasc Interv2021;14:e010686

[74]

Akerström F,Jensen-Urstad M.Feasibility of a novel algorithm for automated reconstruction of the left atrial anatomy based on intracardiac echocardiography.Pacing Clin Electrophysiol2022;45:1288-94 PMCID:PMC9828825

[75]

Hemam ME,Schurmann PA.Left atrial appendage closure with the Watchman device using intracardiac vs transesophageal echocardiography: procedural and cost considerations.Heart Rhythm2019;16:334-42 PMCID:PMC6400300

[76]

Alkhouli M,Alqahtani F,Raybuck B.Outcomes of routine intracardiac echocardiography to guide left atrial appendage occlusion.JACC Clin Electrophysiol2020;6:393-400

[77]

Winkle RA,Engel G,Patrawala RA.Physician-controlled costs: the choice of equipment used for atrial fibrillation ablation.J Interv Card Electrophysiol2013;36:157-65 PMCID:PMC3606509

[78]

Duncker D,Guerra F.Reprocessing of electrophysiology material in EHRA countries: an EHRA Young EP survey.EP Eur2021;23:479-85

[79]

Velagic V,Prepolec I.Feasibility and safety of reprocessing of intracardiac echocardiography catheters for electrophysiology procedures - a large single center experience.Cardiovasc Ultrasound2023;21:20 PMCID:PMC10601175

PDF

1

Accesses

0

Citation

Detail

Sections
Recommended

/

〈 〉