Microvascular dysfunction following cardioplegic arrest and cardiopulmonary bypass

Abstract

Cardioplegia and cardiopulmonary bypass (CP/CPB) during cardiac surgery may cause systemic microvascular dysfunction. CP/CPB is associated with significant alterations in myogenic tone, agonist-induced vasomotor response, and endothelial function in various organs and vascular beds. These alterations can result in vessel spasm, organ malperfusion, and tissue damage. This review summarizes the current state of research in this field.

Keywords

Microcirculation / microvascular function / cardiac surgery / cardioplegia / cardiopulmonary bypass / vasomotor tone / myogenic tone / endothelial function

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