The intracoronary injection of recombinant human prourokinase in emergency interventional therapy for high thrombus load during ST-segment elevation myocardial infarction: a retrospective cohort study

Abstract

Aim: The clinical effect of the injection of recombinant human prourokinase to infarction-related arteries during percutaneous coronary intervention (PCI) in ST-segment elevation myocardial infarction (STEMI) patients who have slow reflow/no reflow was investigated.

Methods: Data from STEMI patients who underwent emergency PCI at the Chest Pain Center of the First People’s Hospital of Changde City from April 2017 to December 2018 were collected for analysis.

Results: Whether the ST segment had decreased by more than 50% at 90 min and whether the creatine kinase isoenzyme and cardiac troponin I had decreased by more than 50% were investigated. There were no significant differences in the indexes of color Doppler echocardiography (left ventricular ejection fraction, left ventricular end-diastolic diameter, ventricular aneurysm, and ventricular thrombus) within seven days after surgery and in the ventricular tachycardia/ventricular fibrillation between the two groups (P > 0.05). There was no significant difference in major adverse cardiovascular event between the two groups within one month after surgery (P > 0.05), but, there were significant differences in the Thrombolysis in Myocardial Infarction (TIMI) classification, corrected TIMI frame count, creatine kinase peak value, and the third-degree atrioventricular block (P < 0.05).

Conclusion: The intracoronary injection of recombinant human prourokinase in patients with STEMI undergoing emergency PCI is safe and effective.

Keywords

ST-segment elevation myocardial infarction / primary percutaneous coronary intervention / recombinant human prourokinase / infarction-related artery

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