Del Nido cardioplegia: from an infant conceive to an adult life - a brief review of the current evidence in adult patients

Abstract

The increasing number of minimally invasive procedures prompted the quest for a simple and effective single shot cardioplegia to allow the surgeons to focus on their workflow. The originally pediatric Del Nido solution was successfully tested in several centers and gradually extended to regular coronary and valvular cases. In the present review we report the current evidence on the use of the Del Nido solution in adult patients.

Keywords

Del Nido cardioplegia / adult cardioplegia / myocardial protection / blood cardioplegia / single shot cardioplegia

References

[1] Jacobs JP,Mayer JE Jr,D'Agostino RS.The society of thoracic surgeons national database 2018 annual report..Ann Thorac Surg2018;106:1603-11

[2] Spellman J.In Favor of More Generalized Use of del Nido cardioplegia in Adult Patients Undergoing Cardiac Surgery..J Cardiothorac Vasc Anesth2019;6:1785-90

[3] Mick SL,Houghtaling PL,Soltesz EG.Del nido versus Buckberg cardioplegia in adult isolated valve surgery..J Thorac Cardiovasc Surg2015;149:626-634discussion 634-6

[4] Guajardo Salinas G.E,Rodriguez-Araujo G.Del Nido cardioplegia in low risk adults undergoing first time coronary artery bypass surgery..Perfusion2017;32:68-73

[5] Magovern JA,Waldhausen JA.Protection of the immature myocardium. An experimental evaluation of topical cooling, single-dose, and multiple-doseadministration of St. Thomas' Hospital cardioplegic solution..J Thorac Cardiovasc Surg1988;96:408-13

[6] Wittnich C,Ianuzzo D,Salerno TA.Relative vulnerability of neonatal and adult hearts to ischemic injury..Circulation1987;76:V156-60

[7] Boland R,Tillack TW.Developmental changes in the composition and function of sarcoplasmic reticulum..J Biol Chem1974;249:612-23

[8] Friedman WF.The intrinsic physiologic properties of the developing heart..Prog Cardiovasc Dis1972;15:87-111

[9] Teoh KH,Weisel RD,Tumiati LC.Effect of oxygen tension and cardiovascular operations on the myocardial antioxidant enzyme activities in patients with tetralogy of Fallot and aorta-coronary bypass..J Thorac Cardiovasc Surg1992;104:159-64

[10] Matte GS.History and use of del Nido cardioplegia solution at boston children's hospital..J Extra Corpor Technol2012;44:98-103 PMCID:PMC4557532

[11] Kim K,Grady P.Use of del Nido cardioplegia for adult cardiacsurgery at the cleveland clinic: perfusion implications..J Extra Corpor Technol2014;46:317-23 PMCID:PMC4557478

[12] Najjar M,Akashi H,Yerebakan H.Feasibility and safety of continuous retrograde administration of del Nido cardioplegia: a case series..J Cardiothorac Surg2015;10:176 PMCID:PMC4662002

[13] Jiang X,Shi E,Xiu Z.Antegrade versus continuous retrograde del Nido cardioplegia in the david i operation..Heart Lung Circ2018;27:497-502

[14] Lazar HL.Del Nido cardioplegia: Passing fad or here to stay?.J Thorac Cardiovasc Surg2018;155:1009-10

[15] Govindapillai A,Rose R,O'Blenes SB.Protecting the aged heart during cardiac surgery: use of del Nido cardioplegia provides superior functional recovery in isolated hearts..J Thorac Cardiovasc Surg2013;146:940-8

[16] O'Blenes SB,Ali A.Protecting the aged heart during cardiac surgery: the potential benefits of del Nido cardioplegia..J Thorac Cardiovasc Surg2011;141:762-70

[17] Ota T,Neely RC,George I.Short-term outcomes in adult cardiac surgery in the use of del Nido cardioplegia solution..Perfusion2016;31:27-33

[18] Sorabella RA,Yerebakan H,Mannan A.Myocardial protection using del Nido cardioplegia solution in adult reoperative aortic valve surgery..J Card Surg2014;29:445-9 PMCID:PMC4297647

[19] Mongero LB.Del Nido cardioplegia-not just kids stuff..J Extra Corpor Technol2016;48:25-8 PMCID:PMC5001531

[20] O'Donnell C,Tran P,Shuttleworth P.Utilization of del Nido cardioplegia in adult coronary artery bypass grafting-a retrospective analysis..Circ J2019;83:342-6

[21] Kim WK,Kim JB,Choo SJ.Del Nido cardioplegia in adult cardiac surgery: beyond single-valve surgery..Interact Cardiovasc Thorac Surg2018;27:81-7

[22] Singh SAS,Spadaccio C,Al-Attar N.An overview of different methods of myocardial protection currently employed peri-transplantation..Vessel Plus2017;1:213-9

[23] Timek T,Hulme O,Nadeau D.Propensity matched analysis of del Nido cardioplegia in adult coronary artery bypass grafting: initial experience with 100 consecutive patients..Ann Thorac Surg2016;101:2237-41

[24] Yerebakan H,Najjar M,Mongero L.Del Nido cardioplegia can be safely administered in high-risk coronary artery bypass grafting surgery after acute myocardial infarction: a propensity matched comparison..J Cardiothorac Surg2014;9:141 PMCID:PMC4220058

[25] Ucak HA.Comparison of del nido and intermittent warm blood cardioplegia in coronary artery bypass grafting surgery..Ann Thorac Cardiovasc Surg2019;25:39-45 PMCID:PMC6388299

[26] Ad N,Massimiano PS,Fornaresio LM.The use of del Nido cardioplegia in adult cardiac surgery: a prospective randomized trial..J Thorac Cardiovasc Surg2018;155:1011-18 PMCID:PMC5929134

[27] Vistarini N,Beauchamp P,Lamarche Y.Del Nido cardioplegia in the setting of minimally invasive aortic valve surgery..Perfusion2017;32:112-7

[28] Hamad R,Laliberte E,Lamarche Y.Comparison of del Nido cardioplegia with blood cardioplegia in adult combined surgery..Innovations (Phila)2017;12:356-62

[29] Ziazadeh D,Himelhoch B,Parker JL.Single-dose del Nido cardioplegia in minimally invasive aortic valve surgery..Semin Thorac Cardiovasc Surg2017;pii: S0022-5223:31194-7

[30] Koeckert M.S.,Vining PF,Beaulieu T.Del Nido cardioplegia for minimally invasive aortic valve replacement..J Card Surg2018;33:64-8

[31] Mishra P,Mohapatra CK,Raut C.Comparison of del Nido cardioplegia and St. Thomas Hospital solution-two types of cardioplegia in adult cardiac surgery..Kardiochir Torakochirurgia Pol2016;13:295-9 PMCID:PMC5233756

[32] Li Y,Zhao Y,Liu D.Del Nido cardioplegia for myocardial protection in adult cardiac surgery: a systematic review and meta-analysis..ASAIO J2018;64:360-367

[33] Pragliola C,Al Otaibi K.The del Nido cardioplegia in adult patients: simple reliable, effective-a propensity matched study of 102 patients with moderate o high Euroscore II..