Glial Wnt dialogue controls synapses

Keywords

Microglia / Astrocyte / Synaptic pruning

Ethical statements

Not applicable.

Author contributions

The authors confirm their contributions to the paper as follows: study conception: Bai X; manuscript writing and revision: Zhao J, Agarwal A, Bai X. All authors reviewed the results and approved the final version of the manuscript.

Data availability

Not applicable.

Acknowledgments

This work was supported by the Startup Grant from China Pharmaceutical University.

Conflict of interest

The authors declare that they have no conflict of interest.

References

[1] Gunner G, Cheadle L, Johnson KM, Ayata P, Badimon A, et al. 2019. Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling. Nature Neuroscience 22:1075-1088

[2] Scott-Hewitt N, Perrucci F, Morini R, Erreni M, Mahoney M, et al. 2020. Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia. The EMBO Journal 39:e105380

[3] Ding X, Wang J, Huang M, Chen Z, Liu J, et al. 2021. Loss of microglial SIRPα promotes synaptic pruning in preclinical models of neurodegen-eration. Nature Communications 12:2030

[4] Schafer DP, Lehrman EK, Kautzman AG, Koyama R, Mardinly AR, et al. 2012. Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner. Neuron 74:691-705

[5] Schafer DP, Stevens B. 2013. Phagocytic glial cells: sculpting synaptic circuits in the developing nervous system. Current Opinion in Neurobiol-ogy 23:1034-1040

[6] Araque A, Parpura V, Sanzgiri RP, Haydon PG. 1999. Tripartite synapses: glia, the unacknowledged partner. Trends in Neurosciences 22:208-125

[7] Chung WS, Clarke LE, Wang GX, Stafford BK, Sher A, et al. 2013. Astro-cytes mediate synapse elimination through MEGF10 and MERTK path-ways. Nature 504:394-400

[8] Stevens B, Allen NJ, Vazquez LE, Howell GR, Christopherson KS, et al. 2007. The classical complement cascade mediates CNS synapse elimi-nation. Cell 131:1164-1178

[9] Faust TE, Lee YH, O'Connor CD, Boyle MA, Gunner G, et al. 2025. Microglia-astrocyte crosstalk regulates synapse remodeling via Wnt signaling. Cell 188:5212-5230.e21

[10] Terry RD, Masliah E, Salmon DP, Butters N, DeTeresa R, et al. 1991. Phys-ical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Annals of Neurology 30:572-580

[11] Rodríguez-Arellano JJ, Parpura V, Zorec R, Verkhratsky A. 2016. Astro-cytes in physiological aging and Alzheimer's disease. Neuroscience 323:170-182

[12] Wetherington J, Serrano G, Dingledine R. 2008. Astrocytes in the epileptic brain. Neuron 58:168-178

[13] Nemes-Baran AD, White DR, DeSilva TM. 2020. Fractalkine-dependent microglial pruning of viable oligodendrocyte progenitor cells regu-lates myelination. Cell Reports 32:108047

[14] Medved J, Wood WM, van Heyst MD, Sherafat A, Song JY, et al. 2021. Novel guanidine compounds inhibit platelet-derived growth factor receptor alpha transcription and oligodendrocyte precursor cell proli-feration. Glia 69:792-811

[15] Molina-Gonzalez I, Holloway RK, Jiwaji Z, Dando O, Kent SA, et al. 2023. Astrocyte-oligodendrocyte interaction regulates central nervous system regeneration. Nature Communications 14:3372