Recent advances in ionogels for biomedical applications: wound healing, drug delivery, tissue engineering and bioadhesion

Qiongfang Nie , Wenqing He , Wenbo Dong , Fenggui Chen , Hongxiang Li , Ke Li , Liang Tian , Xiaoqing Ming , Shijie Ren

Soft Science ›› 2026, Vol. 6 ›› Issue (1) -18.

PDF
Soft Science ›› 2026, Vol. 6 ›› Issue (1) -18. DOI: 10.20517/ss.2025.124
Review Article
Recent advances in ionogels for biomedical applications: wound healing, drug delivery, tissue engineering and bioadhesion
Author information +
History +
PDF

Abstract

Ionogels are a class of soft materials comprising a three-dimensional network that immobilizes ionic liquids (ILs). They have drawn considerable attention due to a suite of exceptional and tunable physicochemical properties, such as nonvolatility, excellent thermal and electrochemical stability, adjustable mechanical strength and high ionic conductivity. Building upon these inherent properties and by leveraging the functions of selected ILs, research interest is increasingly shifting toward their biocompatible and biofunctional aspects. This review investigates the recent advances of ionogels in the biomedical field, particularly in the past five years, focusing on antibacterial agents, wound healing, drug delivery, tissue engineering, tumor therapy and bioadhesion. As a cutting-edge interdisciplinary field, ionogels present significant opportunities that require close collaboration among scientists to accelerate the transition from the laboratory to industrialization and bring revolutionary advances to human health.

Keywords

Ionogels / wound healing / drug delivery / tissue engineering / bioadhesives

Cite this article

Download citation ▾
Qiongfang Nie, Wenqing He, Wenbo Dong, Fenggui Chen, Hongxiang Li, Ke Li, Liang Tian, Xiaoqing Ming, Shijie Ren. Recent advances in ionogels for biomedical applications: wound healing, drug delivery, tissue engineering and bioadhesion. Soft Science, 2026, 6(1): -18 DOI:10.20517/ss.2025.124

登录浏览全文

4963

注册一个新账户 忘记密码

References

[1]

Gao Y,Shu Y.Research progress of ionic liquids-based gels in energy storage, sensors and antibacterial.Green Chem Eng2021;2:368-83

[2]

Datta D,Bandi SP.Stimuli-responsive self-healing ionic gels: a promising approach for dermal and tissue engineering applications.ACS Biomater Sci Eng2025;11:1338-72 PMCID:PMC11897956

[3]

He W,Zhang J.Emerging applications of bioinspired slippery surfaces in biomedical fields.Chemistry2018;24:14864-77

[4]

Bertsch P,Mooney DJ.Self-healing injectable hydrogels for tissue regeneration.Chem Rev2023;123:834-73 PMCID:PMC9881015

[5]

Pedro AQ,Coutinho JA.Ionogels as advanced materials for overcoming challenges in wound healing and drug delivery.Nano Mater Sci2025;7:599-626

[6]

Kuddushi M,Malek N.Review of ionic liquid and ionogel-based biomaterials for advanced drug delivery.Adv Colloid Interface Sci2024;331:103244

[7]

Karamikamkar S,Haghniaz R.Aerogel-based biomaterials for biomedical applications: from fabrication methods to disease-targeting applications.Adv Sci2023;10:e2204681 PMCID:PMC10427407

[8]

Ju X,Qi G.Photoelectric-driven conductive composite ionogel patch for effective wound healing.eScience2024;4:100223

[9]

Zhang Z,Gao S,Guo J.Antibacterial, anti-inflammatory and wet-adhesive poly(ionic liquid)-based oral patch for the treatment of oral ulcers with bacterial infection.Acta Biomater2023;166:254-65

[10]

Zhang T,Guo J.Active pharmaceutical ingredient poly(ionic liquid)-based microneedles for the treatment of skin acne infection.Acta Biomater2020;115:136-47

[11]

He W,Hou C.Mucus-inspired supramolecular adhesives with oil-regulated molecular configurations and long-lasting antibacterial properties.ACS Appl Mater Interfaces2020;12:16877-86

[12]

Chen Y,Zhang C,Hou C.Antibacterial micro/nanorobots: innovations, challenges, and future perspectives in combatting infection.Nano Select2025;e70084

[13]

Noro J,Reis RL.Extracellular matrix-derived materials for tissue engineering and regenerative medicine: a journey from isolation to characterization and application.Bioact Mater2024;34:494-519 PMCID:PMC10827697

[14]

He W,Lin R.Machine learning assists in the design and application of microneedles.Biomimetics2024;9:469 PMCID:PMC11351824

[15]

Wang F,Dai B,Wen Y.Recent advances in asymmetric wettability dressings for wound exudate management.Research2025;8:0591 PMCID:PMC11729271

[16]

Zielińska A,Eder P.Scaffolds for drug delivery and tissue engineering: the role of genetics.J Control Release2023;359:207-23

[17]

Boruah M.Dry gels: concept, current trends, and new avenues in drug delivery and biomedical application.Adv Healthc Mater2025;14:e00863

[18]

Fan X,Jia Z.Ionogels: recent advances in design, material properties and emerging biomedical applications.Chem Soc Rev2023;52:2497-527

[19]

Cao Z,Jiang L.Transparent, mechanically robust, and ultrastable ionogels enabled by hydrogen bonding between elastomers and ionic liquids.Mater Horiz2020;7:912-8

[20]

Marr PC.Ionic liquid gel materials: applications in green and sustainable chemistry.Green Chem2016;18:105-28

[21]

Lu G,Wang Z.High-performance supramolecular organogel adhesives for antimicrobial applications in diverse conditions.ACS Appl Mater Interfaces2023;15:44194-204

[22]

Wang Z,Wu M.Bioinspired supramolecular slippery organogels for controlling pathogen spread by respiratory droplets.Adv Funct Mater2021;31:2102888

[23]

Susan MABH,Watanabe M.Ion gels prepared by in situ radical polymerization of vinyl monomers in room temperature ionic liquids as novel highly conductive polymer electrolytes.J Am Chem Soc2005;127:4976-83

[24]

Gao Y,Li L,Shu Y.Ionic liquid-based gels for biomedical applications.Chem Eng J2023;452:139248

[25]

Chen N,Li L,Guo S.Ionogel electrolytes for high-performance lithium batteries: a review.Adv Energy Mater2018;8:1702675

[26]

Ahangaran F.Functionalized ionogels with self-healing performance: material design, chemistry aspects, applications, and future prospects.Adv Colloid Interface Sci2025;345:103633

[27]

Luo Z,Yan J.Roles of ionic liquids in adjusting nature of ionogels: a mini review.Adv Funct Mater2022;32:2203988

[28]

Singh A,Singh N.Development and characterization of gelatin/carboxymethyl cellulose based polymeric film with inclusion of ionic liquid to enhance the shelf life of food.Food Packag Shelf Life2024;42:101251

[29]

Xiong J,Zou X.Biocompatible tough ionogels with reversible supramolecular adhesion.J Am Chem Soc2024;146:13903-13

[30]

Sharma A,Solanki PR.Self-healing gelatin ionogels.Int J Biol Macromol2017;95:603-7

[31]

Le K,Chen J.Stretchable, self-healing, biocompatible, and durable ionogel for continuous wearable strain and physiological signal monitoring.Chem Eng J2023;471:144675

[32]

Ding Y,Chang L,Liu H.Preparation of high-performance ionogels with excellent transparency, good mechanical strength, and high conductivity.Adv Mater2017;29:1704253

[33]

Luo Z,Guo J.Poly(ionic liquid)/Ce-based antimicrobial nanofibrous membrane for blocking drug-resistance dissemination from MRSA-infected wounds.Adv Funct Mater2021;31:2100336

[34]

Ananieva G,Nguyen GT.Bio-friendly artificial muscles based on carbon nanotube yarns and eutectogel derivatives.Adv Funct Mater2025;36:e15458

[35]

He W,Kong S.Intelligent sensing: the emerging integration of machine learning and soft sensors based on hydrogels and ionogels.Adv Sci2025;12:e17851 PMCID:PMC12752558

[36]

Liu C,Qian H.Recent advances in poly(ionic liquid)s for biomedical application.Biomater Sci2022;10:2524-39

[37]

Niu H,Kim ES.Advances in flexible sensors for intelligent perception system enhanced by artificial intelligence.InfoMat2023;5:e12412

[38]

Jiang N,Hu D.Flexible, transparent, and antibacterial ionogels toward highly sensitive strain and temperature sensors.Chem Eng J2021;424:130418

[39]

Yang J,Cheng T.All-in-one and on-demand wound dressing based on a deep eutectic solvent ionic gel.Chem Eng J2025;515:163849

[40]

Raptis K,Cunha C.Permeation enhancer-based ionogel shows remarkable potential for oral insulin delivery.Adv Healthc Mater2025;14:e2500946 PMCID:PMC12333474

[41]

Kim JS,Lim JW.Implantable multi-cross-linked membrane-ionogel assembly for reversible non-faradaic neurostimulation.ACS Nano2023;17:14706-17

[42]

Ju X,Qi G.A wearable electrostimulation-augmented ionic-gel photothermal patch doped with MXene for skin tumor treatment.Nat Commun2024;15:762 PMCID:PMC10817919

[43]

Jiang C,Zhang H.Self-reinforcing ionogel bioadhesive interface for robust integration and monitoring of bioelectronic devices with hard tissues.Adv Mater2025;37:e2413028

[44]

Wang H,Yang J,Zhang Q.Ionic gels and their applications in stretchable electronics.Macromol Rapid Commun2018;e1800246

[45]

Yan CC,Liu Z.Ionogels: preparation, properties and applications.Adv Funct Mater2023;34:2314408

[46]

Xia Q,Zou X.Metal-organic framework (MOF) facilitated highly stretchable and fatigue-resistant ionogels for recyclable sensors.Mater Horiz2022;9:2881-92

[47]

Ueki T.Macromolecules in ionic liquids: progress, challenges, and opportunities.Macromolecules2008;41:3739-49

[48]

Le Bideau, J.; Viau, L.; Vioux, A. Ionogels, ionic liquid based hybrid materials.Chem Soc Rev2011;40:907-25

[49]

Ye Y,Hwang B.Ionic liquid polymer electrolytes.J Mater Chem A2013;1:2719-43

[50]

Dai S,Gao HJ,Pennycook SJ.Preparation of silica aerogel using ionic liquids as solvents.Chem Commun2000;243-4

[51]

Wu S,Xing W.Backbone structure effect on the thermoelectric properties of IDT-based p-type conjugated polymers.Macromol Rapid Commun2020;41:e1900322

[52]

Wang M,Dickey MD.Tough ionogels: synthesis, toughening mechanisms, and mechanical properties - a perspective.JACS Au2022;2:2645-57 PMCID:PMC9795568

[53]

He W,Xiang Y.Bioinspired semicrystalline dynamic ionogels with adaptive mechanics and tactile sensing.ACS Appl Mater Interfaces2022;14:20132-8

[54]

Ming X,Zhu H.Stretchable, phase-transformable ionogels with reversible ionic conductor–insulator transition.Adv Funct Mater2020;30:2005079

[55]

Ren Y,Liu Z.Ionic liquid-based click-ionogels.Sci Adv2019;5:eaax0648 PMCID:PMC6707778

[56]

Zhu J,Zhang W.Substrate-independent, reversible, and easy-release ionogel adhesives with high bonding strength.Macromol Rapid Commun2020;41:e2000098

[57]

Wang S,Alper JP,Wang Z.Comparative studies on electrochemical cycling behavior of two different silica-based ionogels.J Power Sources2016;301:299-305

[58]

Viau L,Devoisselle JM.Ionogels as drug delivery system: one-step sol-gel synthesis using imidazolium ibuprofenate ionic liquid.Chem Commun2010;46:228-30

[59]

Ye L,Liu J.Responsive ionogel surface with renewable antibiofouling properties.Macromol Rapid Commun2019;40:e1900395

[60]

Suen JW,Debnath S,Lim CI.The role of interfaces in ionic liquid-based hybrid materials (ionogels) for sensing and energy applications.Adv Mater Inter2022;9:2201405

[61]

Bielejewski M.Effect of self-assembly aggregation on physical properties of non-aqueous ionogels based on LMWG.J Sol Gel Sci Technol2018;88:671-83

[62]

Huang Y,Tang Z.Ultra-strong ionogel adhesives via in situ microphase separation.Adv Funct Mater2024;35:2417011

[63]

Wang J,Cui T.Bioinspired ultra-robust ionogels constructed with soft-rigid confinement space for multimodal monitoring electronics.Adv Funct Mater2023;34:2312383

[64]

Xu Q,Wang B,Yan F.Zinc ion coordinated poly(ionic liquid) antimicrobial membranes for wound healing.ACS Appl Mater Interfaces2017;9:14656-64

[65]

Jiang H,Zhang X.Progress of ionogels in flexible pressure sensors: a mini-review.Polymers2025;17:1093 PMCID:PMC12030016

[66]

Kim MS,Yoo H.Ultrastretchable, tough, and highly conductive ionogels for multipurpose motion monitoring.ACS Mater Lett2024;6:4658-66

[67]

Pan H,Huang X.Biosafety, anti-swelling and anti-freezing amino acid-based ionogels for flexible strain sensors.Chem Eng J2025;520:166097

[68]

Li W,Liu Z,Li Q.Supramolecular ionogels tougher than metals.Adv Mater2023;35:e2301383

[69]

Sun L,Zhang L.Spider-silk-inspired tough, self-healing, and melt-spinnable ionogels.Adv Sci2024;11:e2305697 PMCID:PMC10797445

[70]

Zhou Y,Luo Y.Simultaneous enhancement of mechanical properties and ionic conductivity of sustainable and antibacterial Ionogels by cellulose acetate for versatile flexible sensors.Chem Eng J2025;524:169307

[71]

Correia DM,Martins PM.Ionic liquid–polymer composites: a new platform for multifunctional applications.Adv Funct Mater2020;30:1909736

[72]

Hu Y,Yue H.Ionic liquids revolutionizing biomedicine: recent advances and emerging opportunities.Chem Soc Rev2023;52:7262-93

[73]

Liu G,Hu R.Applications of ionic liquids in biomedicine.Biophys Rev Lett2013;07:121-34

[74]

Patel V,Bhargava A,Modi A.Ionogels for flexible conductive substrates and their application in biosensing.Int J Biol Macromol2024;254:127736

[75]

Ni B,Ananieva G.Artificial muscle based on coiled CNT yarns and biofriendly ionogels.Sens Actuators B Chem2024;403:135227

[76]

Huo X,Cong Z.Strong and tough eutectogels with broad-range tunable mechanical properties via the hydrogen bond network-specific effect.Adv Funct Mater2025;35:2422464

[77]

Zhang Y,Zhang Y.Biomimetic lignin/poly(ionic liquids) composite hydrogel dressing with excellent mechanical strength, self-healing properties, and reusability.Chem Eng J2020;400:125984

[78]

Jiang J,Li Z.Gel polymer electrolytes prepared by in situ polymerization of vinyl monomers in room-temperature ionic liquids.React Funct Polym2006;66:1141-8

[79]

Wang M,Dickey MD.Emerging applications of tough ionogels.NPG Asia Mater2023;15:66

[80]

Sun J,Zhou J,Zhu X.Robust physically linked double-network ionogel as a flexible bimodal sensor.ACS Appl Mater Interfaces2020;12:14272-9

[81]

Zhao X.Multi-scale multi-mechanism design of tough hydrogels: building dissipation into stretchy networks.Soft Matter2014;10:672-87 PMCID:PMC4040255

[82]

Li X,Zhang Y.Stimulation-reinforced cellulose–protein ionogels with superior mechanical strength and temperature resistance.Adv Funct Mater2024;34:2408160

[83]

Zhang J,Li M,Wang H.Development of ultrathin, breathable, waterproof, and durable nanonet-supported ionogel sensors for electrophysiological monitoring.Adv Funct Mater2024;35:2415694

[84]

Kuddushi M,Rajput S,Mata JP.Temperature-responsive low molecular weight ionic liquid based gelator: an approach to fabricate an anti-cancer drug-loaded hybrid ionogel.ChemSystemsChem2020;2:e1900053

[85]

Kuddushi M,Aswal V,Malek N.Poly(vinyl alcohol) and functionalized ionic liquid-based smart hydrogels for doxorubicin release.ACS Appl Bio Mater2020;3:4883-94

[86]

Kuddushi M,Singh DK,Malek N.An ionic hydrogel with stimuli-responsive, self-healable and injectable characteristics for the targeted and sustained delivery of doxorubicin in the treatment of breast cancer.Mater Adv2022;3:632-46

[87]

Zhao X,Zhang J.Fluorescent double network ionogels with fast self-healability and high resilience for reliable human motion detection.Mater Horiz2023;10:646-56

[88]

Zhang M,Tian F.Bionic artificial skin based on self-healable ionogel composites with tailored mechanics and robust interfaces.Adv Mater2024;36:e2405776

[89]

Adawiyah N,Hawatulaila S.Ionic liquids as a potential tool for drug delivery systems.Med Chem Commun2016;7:1881-97

[90]

Lewandowski A.Properties of the lithium and graphite–lithium anodes in N-methyl-N-propylpyrrolidinium bis(trifluoromethanesulfonyl)imide.J Power Sources2009;194:502-7

[91]

Lewandowski A.Ionic liquids as electrolytes for Li-ion batteries - an overview of electrochemical studies.J Power Sources2009;194:601-9

[92]

Ma L,He J.Ultra-sensitive, durable and stretchable ionic skins with biomimetic micronanostructures for multi-signal detection, high-precision motion monitoring, and underwater sensing.J Mater Chem A2021;9:26949-62

[93]

Han J,Lee J,Jo S.UV curable ionogel for all-solid-state supercapacitor.Chem Eng J2021;416:129089

[94]

Qian W,Yan F.Frontiers in poly(ionic liquid)s: syntheses and applications.Chem Soc Rev2017;46:1124-59

[95]

Chen H,Salas-de La Cru D,Elabd YA.Polymerized ionic liquids: the effect of random copolymer composition on ion conduction.Macromolecules2009;42:4809-16

[96]

Zhang SY,Zhang M.Poly(ionic liquid) composites.Chem Soc Rev2020;49:1726-55

[97]

Guo J,Zhou Y.Poly(ionic liquid)-based energy and electronic devices.Chin J Chem2022;40:1099-108

[98]

Su Q,Wang S,Dong J.Choline-amino acid-based polyionic liquids and ionogels for antimicrobial infections.Mater Today Commun2024;40:109593

[99]

Lei B,Qu X.Thermal-sensitive ionogel with NIR-light controlled adhesion for ultrasoft strain sensor.Nano Res2023;16:5464-72

[100]

Sun Y,Guo B,Niu W.Mussel-inspired tough ionogel with robust adhesion and mechanical adaptivity for impact resistance.Chem Eng J2024;498:155059

[101]

Wang S,Li S.Self-contained underwater adhesion and informational labeling enabled by arene-functionalized polymeric ionogels.Adv Funct Mater2023;33:2306814

[102]

Cheng Y,Zhang J.Tough, stretchable, and adhesive ionogels for impact resistance and wearable ionotronics.Chem Eng J2025;522:167762

[103]

Pan T,Mao L.Highly adhesive and conductive eco-friendly Mg/B-SA/PVA ionogels.Chem Eng J2025;522:167816

[104]

Laxminarayan R.Antibiotic effectiveness: balancing conservation against innovation.Science2014;345:1299-301

[105]

Ng VWL,Leong J,Hedrick JL.Antimicrobial polycarbonates: investigating the impact of nitrogen-containing heterocycles as quaternizing agents.Macromolecules2014;47:1285-91

[106]

Liu P,Wong W.Ionic liquid functionalized non-releasing antibacterial hydrogel dressing coupled with electrical stimulation for the promotion of diabetic wound healing.Chem Eng J2021;415:129025

[107]

Lu J,Texter J.Advanced applications of ionic liquids in polymer science.Prog Polym Sci2009;34:431-48

[108]

Torimoto T,Okazaki K.New frontiers in materials science opened by ionic liquids.Adv Mater2010;22:1196-221

[109]

Demberelnyamba D,Choi S.Synthesis and antimicrobial properties of imidazolium and pyrrolidinonium salts.Bioorg Med Chem2004;12:853-7

[110]

Hajebi S,Bagherzadeh M.Stimulus-responsive polymeric nanogels as smart drug delivery systems.Acta Biomater2019;92:1-18 PMCID:PMC6661071

[111]

Carmona-Ribeiro AM.Cationic antimicrobial polymers and their assemblies.Int J Mol Sci2013;14:9906-46 PMCID:PMC3676821

[112]

Borkowski A,Cłapa T.Different antibacterial activity of novel theophylline-based ionic liquids - growth kinetic and cytotoxicity studies.Ecotoxicol Environ Saf2016;130:54-64

[113]

Zheng Z,Mao H,Qin J.Metal-containing poly(ionic liquid) membranes for antibacterial applications.ACS Biomater Sci Eng2017;3:922-8

[114]

Zheng Z,Guo J.Structure-antibacterial activity relationships of imidazolium-type ionic liquid monomers, poly(ionic liquids) and poly(ionic liquid) membranes: effect of alkyl chain length and cations.ACS Appl Mater Interfaces2016;8:12684-92

[115]

Guo J,Zheng Z.Intrinsically antibacterial poly(ionic liquid) membranes: the synergistic effect of anions.ACS Macro Lett2015;4:1094-8

[116]

Qin J,Xu Q,Mao H.Synthesis of pyrrolidinium-type poly(ionic liquid) membranes for antibacterial applications.ACS Appl Mater Interfaces2017;9:10504-11

[117]

Fernandes MM,Correia DM.Ionic liquids as biocompatible antibacterial agents: a case study on structure-related bioactivity on Escherichia coli.ACS Appl Bio Mater2022;5:5181-9 PMCID:PMC9778738

[118]

Singh G,Damarla K,Kumar A.Gelatin-based highly stretchable, self-healing, conducting, multiadhesive, and antimicrobial ionogels embedded with Ag2O nanoparticles.ACS Sustainable Chem Eng2017;5:6568-77

[119]

Zheng S,Ren Y.Moisture-wicking, breathable, and intrinsically antibacterial electronic skin based on dual-gradient poly(ionic liquid) nanofiber membranes.Adv Mater2022;34:e2106570

[120]

Krishnadoss V,Kanjilal B.Bioionic liquid conjugation as universal approach to engineer hemostatic bioadhesives.ACS Appl Mater Interfaces2019;11:38373-84

[121]

Md Moshikur, R.; Chowdhury, M. R.; Moniruzzaman, M.; Goto, M. Biocompatible ionic liquids and their applications in pharmaceutics.Green Chem2020;22:8116-39

[122]

Wheelis SE,Natarajan S.Investigation of the early healing response to dicationic imidazolium-based ionic liquids: a biocompatible coating for titanium implants.ACS Biomater Sci Eng2020;6:984-94 PMCID:PMC7351359

[123]

Shen L,Yu J.Self-polymerized metal-phenolic ionogel with multifunctional properties towards theranostic wearable electronics.Acta Biomater2025;199:154-65

[124]

Zhang T,Ding Y,Yan F.Redox-responsive ferrocene-containing poly(ionic liquid)s for antibacterial applications.Sci China Chem2018;62:95-104

[125]

Sun D,Cheng Y.Ultrasound-switchable nanozyme augments sonodynamic therapy against multidrug-resistant bacterial infection.ACS Nano2020;14:2063-76

[126]

Yelin I.Antibiotic resistance.Cell2018;172:1136-e1

[127]

Gao Y,Zhang W,Shu Y.Microwave-triggered ionic liquid-based hydrogel dressing with excellent hyperthermia and transdermal drug delivery performance.Chem Eng J2022;429:131590

[128]

Villar-Chavero MM,Alonso MV,Rodriguez F.Chitosan-reinforced cellulosic bionogels: viscoelastic and antibacterial properties.Carbohydr Polym2020;229:115569

[129]

Lin B,Xie D,Zhao P.pH-Responsive charge convertible hyperbranched poly(ionic liquid) nanoassembly with high biocompatibility for resistance-free antimicrobial applications.Nano Lett2024;24:7408-16

[130]

Duflo S,Li W,Prestwich GD.Vocal fold tissue repair in vivo using a synthetic extracellular matrix.Tissue Eng2006;12:2171-80

[131]

Chen K,Liu Y,Liu C.Injectable double-crosslinked adhesive hydrogels with high mechanical resilience and effective energy dissipation for joint wound treatment.Adv Funct Mater2021;32:2109687

[132]

Nikfarjam N,Agarwal T.Antimicrobial ionic liquid-based materials for biomedical applications.Adv Funct Mater2021;31:2104148

[133]

Bhar B,Ramesh VK.Wearable e-Bandage with antimicrobial ionogel as an integrated electroceutical device for accelerated wound healing.ACS Mater Lett2024;6:3453-61

[134]

Gao S,Wang X.Chlorella-loaded antibacterial microneedles for microacupuncture oxygen therapy of diabetic bacterial infected wounds.Adv Mater2024;36:e2307585

[135]

Zhi H,Zhang X.Green, pH-sensitive, highly stretchable, and hydrogen bond-dominated ionogel for wound healing activity.ACS Appl Bio Mater2024;7:498-507

[136]

Wang Y,Liu Z.Janus fibrous dressing with controllable nitric oxide-releasing and unidirectional exudate transport activities for bacteria-infected burn wound therapy.Adv Funct Mater2025;35:2503992

[137]

Vaidya A.Ionic liquid-mediated delivery of insulin to buccal mucosa.J Control Release2020;327:26-34

[138]

Datta D,Venuganti VVK.Influence of choline-based ionogel on transdermal delivery of vancomycin hydrochloride.Mol Pharm2025;22:3331-50 PMCID:PMC12135064

[139]

Gao YR,Wei YN.Ionic liquids enable the preparation of a copper-loaded gel with transdermal delivery function for wound dressings.Biomater Sci2022;10:1041-52

[140]

Mokhtarpour M,Shayanfar A.Design and characterization of ascorbic acid based therapeutic deep eutectic solvent as a new ion-gel for delivery of sunitinib malate.J Drug Deliv Sci Technol2020;56:101512

[141]

Bhamble S,Katari O,Ansari MM.Ionic liquid-based ionogel: a novel strategy to improve dermal delivery and in vivo efficacy of etodolac in rheumatoid arthritis management.J Mol Liq2024;412:125841

[142]

Hermida-Merino C,Gracia-Fernández C.Ionogels derived from fluorinated ionic liquids to enhance aqueous drug solubility for local drug administration.Gels2022;8:594 PMCID:PMC9498591

[143]

Jadhav N,Patil P,Mane M.Thermoreversible ionogel for enhanced nose-to-brain delivery of tetrabenazine hydrochloride: optimization by central composite design and in vitro ex vivo evaluation.AAPS PharmSciTech2025;26:210

[144]

Gupta MK,Phillips DM.Patterned silk films cast from ionic liquid solubilized fibroin as scaffolds for cell growth.Langmuir2007;23:1315-9

[145]

Li X.Smart collagen hydrogels based on 1-ethyl-3-methylimidazolium acetate and microbial transglutaminase for potential applications in tissue engineering and cancer therapy.ACS Biomater Sci Eng2019;5:3523-36

[146]

Correia DM,Fernandes MM.Ionic liquid-based materials for biomedical applications.Nanomaterials2021;11:2401 PMCID:PMC8471968

[147]

Ali I,Hussain K.Ionic liquids enhanced performance of PVC gels actuator.J Appl Polym Sci2021;138:50710

[148]

Nevstrueva D,Vunder V.Natural cellulose ionogels for soft artificial muscles.Colloids Surf B Biointerfaces2018;161:244-51

[149]

Huang Y,Zhang Q.Ionogel adhesives: from structural design to emerging applications.Macromol Rapid Commun2025;46:e2400973

[150]

Hou C,Yao X.Mucus-inspired supramolecular adhesives: exploring the synergy between dynamic networks and functional liquids.ACS Nano2025;19:14540-56 PMCID:PMC12020425

[151]

Hou C,Wang Z.Particulate-aggregated adhesives with exudate-sensitive properties and sustained bacteria disinfection to facilitate wound healing.ACS Appl Mater Interfaces2020;12:31090-8

[152]

Ge G,Haghniaz R.Deep eutectic solvents-based ionogels with ultrafast gelation and high adhesion in harsh environments.Adv Funct Mater2023;33:2207388 PMCID:PMC10118073

[153]

Qi J,An S.Hydrophobic ionogel with mitigated sea-island structure: exhibiting ultrahigh adhesion via cellulose-mediated energy dissipation.J Colloid Interface Sci2026;705:139459

PDF

0

Accesses

0

Citation

Detail

Sections
Recommended

/