A dual-mode wearable sensor with coupled ion and pressure sensing

Abstract

Simultaneous monitoring of the body’s biochemical and biophysical signals via wearable devices can provide a comprehensive assessment of an individual’s health state. However, current multifunctional sensors for synchronous biochemical and biophysical sensing rely on discrete sensing units, posing a limitation in increased complexity in device assembly, signal processing, and system integration. In this study, we report a dual-mode and self-powered wearable sensor with ion and pressure-sensing capabilities by interfacing a hydrogel film with a solid ion-selective electrode. The hydrogel film can not only collect natural sweat from the skin but also offer a piezoionic response to pressure. We show that wrist pulse-induced pressure response can be incorporated into the noise of the response to sweat sodium ions, allowing for the simultaneous measurement of heart rate and sweat electrolytes. This work provides an example of simplifying the development of wearable multimode sensors through the rational design of classic electrochemical sensors.

Keywords

Wearable sweat sensor / ion selective electrode / piezoionic response / hydrogel

References

[1] Yu Y,Gao W.Flexible electrochemical bioelectronics: the rise of in situ bioanalysis.Adv Mater2020;32:1902083

[2] Ates HC,Gonzalez-Macia L.End-to-end design of wearable sensors.Nat Rev Mater2022;7:887-907 PMCID:PMC9306444

[3] DeMello A.Wearable sensors.ACS Sens2023;8:1368-70

[4] Singh SU,Lone SA.Advanced wearable biosensors for the detection of body fluids and exhaled breath by graphene.Mikrochim Acta2022;189:236 PMCID:PMC9146825

[5] Shen J,Yang Y.Application, challenge and perspective of triboelectric nanogenerator as micro-nano energy and self-powered biosystem.Biosens Bioelectron2022;216:114595

[6] Su Y,Zhao X.A wireless energy transmission enabled wearable active acetone biosensor for non-invasive prediabetes diagnosis.Nano Energy2020;74:104941

[7] Ji W,Wu W.Wearable sweat biosensors refresh personalized health/medical diagnostics.Research2021;2021:9757126 PMCID:PMC8557357

[8] Wang Y,Guo S.Skin bioelectronics towards long-term, continuous health monitoring.Chem Soc Rev2022;51:3759-93

[9] Trung TQ.Flexible and stretchable physical sensor integrated platforms for wearable human-activity monitoringand personal healthcare.Adv Mater2016;28:4338-72

[10] Ma B,Chi J,Zhao C.A versatile approach for direct patterning of liquid metal using magnetic field.Adv Funct Mater2019;29:1901370

[11] Gao FL,Gao XZ.Integrated temperature and pressure dual-mode sensors based on elastic PDMS foams decorated with thermoelectric PEDOT:PSS and carbon nanotubes for human energy harvesting and electronic-skin.J Mater Chem A2022;10:18256-66

[12] Ma B,Chen G.Shape-programmable liquid metal fibers.Biosensors2023;13:28 PMCID:PMC9856024

[13] Byfield R,Miles J,Lin J.Towards robust blood pressure estimation from pulse wave velocity measured by photoplethysmography sensors.IEEE Sens J2022;22:2475-83

[14] Sempionatto JR,Mahato K,Gao W.Wearable chemical sensors for biomarker discovery in the omics era.Nat Rev Chem2022;6:899-915 PMCID:PMC9666953

[15] Wang M,Min J.A wearable electrochemical biosensor for the monitoring of metabolites and nutrients.Nat Biomed Eng2022;6:1225-35 PMCID:PMC10432133

[16] Chen Y,Zuo Y.Versatile sweat bioanalysis on demand with hydrogel-programmed wearables.Biosens Bioelectron2023;235:115412

[17] He T,Yang Y,Liu W.Emerging wearable chemical sensors enabling advanced integrated systems toward personalized and preventive medicine.Anal Chem2023;95:490-514

[18] Gao W,Kiriya D,Javey A.Flexible electronics toward wearable sensing.Acc Chem Res2019;52:523-33

[19] Ray TR,Bandodkar AJ.Bio-integrated wearable systems: a comprehensive review.Chem Rev2019;119:5461-533

[20] Gao W,Nyein HYY.Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis.Nature2016;529:509-14 PMCID:PMC4996079

[21] Nakata S,Akita S.Wearable, flexible, and multifunctional healthcare device with an ISFET chemical sensor for simultaneous sweat pH and skin temperature monitoring.ACS Sens2017;2:443-8

[22] Zhang X,Liu Y,Zhang Q.Integrated wearable sensors for sensing physiological pressure signals and β-hydroxybutyrate in physiological fluids.Anal Chem2022;94:993-1002

[23] Min J,Xu C.Skin-interfaced wearable sweat sensors for precision medicine.Chem Rev2023;123:5049-138 PMCID:PMC10406569

[24] Bariya M,Javey A.Wearable sweat sensors.Nat Electron2018;1:160-71

[25] Kaur G.Estimation of sodium ions using easily engineered organic nanoparticles-based turn-on fluorescent sensor: application in biological and environmental samples.Sens Actuators B Chem2018;265:134-41

[26] Gonçalves AC,Mendonça RMH.Chloride and sodium ion concentrations in saliva and sweat as a method to diagnose cystic fibrosis.J Pediatr2019;95:443-50

[27] Speedy DB,Schneider C.Exercise-associated hyponatremia: a review.Emerg Med2001;13:17-27

[28] Meng K,Wei W.Wearable pressure sensors for pulse wave monitoring (Adv. Mater. 21/2022).Adv Mater2022;34:2270158

[29] Lin PH,Chen CW,Li BR.Wearable hydrogel patch with noninvasive, electrochemical glucose sensor for natural sweat detection.Talanta2022;241:123187

[30] Nyein HYY,Tran B.A wearable patch for continuous analysis of thermoregulatory sweat at rest.Nat Commun2021;12:1823 PMCID:PMC7987967

[31] Wu X,Evans JW,Arias AC.A potentiometric electronic skin for thermosensation and mechanosensation.Adv Funct Mater2021;31:2010824

[32] Dobashi Y,Petel Y.Piezoionic mechanoreceptors: force-induced current generation in hydrogels.Science2022;376:502-7

[33] Li J,Tang Y.Touchable gustation via a hoffmeister gel iontronic sensor.ACS Nano2023;17:5129-39

[34] Ma B,Xu C,Zhao C.Wearable capillary microfluidics for continuous perspiration sensing.Talanta2020;212:120786

[35] Sekine Y,Zhang Y.A fluorometric skin-interfaced microfluidic device and smartphone imaging module for in situ quantitative analysis of sweat chemistry.Lab Chip2018;18:2178-86

[36] Choi J,Reeder JT.Soft, skin-integrated multifunctional microfluidic systems for accurate colorimetric analysis of sweat biomarkers and temperature.ACS Sens2019;4:379-88

[37] Glennon T,McCaul M.‘SWEATCH’: a wearable platform for harvesting and analysing sweat sodium content.Electroanalysis2016;28:1283-9

[38] Demuru S,Briand D.Real-time multi-ion detection in the sweat concentration range enabled by flexible, printed, and microfluidics-integrated organic transistor arrays.Adv Mater Technol2020;5:2000328

[39] Parrilla M,Cánovas R,Cuartero M.Wearable potentiometric ion patch for on-body electrolyte monitoring in sweat: toward a validation strategy to ensure physiological relevance.Anal Chem2019;91:8644-51

[40] Buono MJ,Kolkhorst FW.Sodium ion concentration vs. sweat rate relationship in humans.J Appl Physiol2007;103:990-4