Preparation and Characterization of Dibenzyldieneacetone Loaded Microparticles for Therapeutic Purposes

Benabdallah Nacira , Abdelmalek Ilham , Debdab Mansour

Sustain. Polym. Energy ›› 2025, Vol. 3 ›› Issue (3) : 10007

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Sustain. Polym. Energy ›› 2025, Vol. 3 ›› Issue (3) :10007 DOI: 10.70322/spe.2025.10007
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Preparation and Characterization of Dibenzyldieneacetone Loaded Microparticles for Therapeutic Purposes
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Abstract

Among the known chalcones, dibenzyldieneacetone is an organic molecule that was synthesized in this study and encapsulated into the Ethyl cellulose matrix by solvent evaporation technique. Microencapsulation aims to shield the core material from environmental influences (like light, humidity, temperature, and oxygen), extend its shelf life, and enhance the product’s quality. The microsphere size distribution was determined using an optical microscope. The synthesis product, as well as the particles, were characterized by ultraviolet-visible, infrared, and XRD. This study allowed us to identify particle morphology, encapsulation rate, and particle size distribution.

Keywords

Chalcones / Microencapsulation / Microspheres

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Benabdallah Nacira, Abdelmalek Ilham, Debdab Mansour. Preparation and Characterization of Dibenzyldieneacetone Loaded Microparticles for Therapeutic Purposes. Sustain. Polym. Energy, 2025, 3(3): 10007 DOI:10.70322/spe.2025.10007

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Acknowledgments

This work was carried out in the Synthesis and Catalysis Laboratory (LSCT) as part of PRFU projects (code: B00L01UN140120220002) funded by the Ministry of Higher Education and Scientific Research of Algeria. Our sincere thanks. Special thanks for the farm animal reproduction laboratories, Tiaret, Algeria.

Author Contributions

Conceptualization, A.I. and D.M.; Methodology, A.I.; Software, B.N.; Validation, A.I.; Formal Analysis, B.N.; Investigation, A.I., D.M.; Resources A.I.; Data Curation, B.N.; Writing—Original Draft Preparation, B.N.; Writing—Review & Editing B.N. and A.I.; Visualization, A.I.; Supervision, A.I. and D.M.; Project Administration; Funding Acquisition; Catalysis Laboratory (LSCT) as part of PRFU projects.

Ethics Statement

Not applicable.

Informed Consent Statement

Not applicable.

Data Availability Statement

Not applicable.

Funding

This work was carried out in the Synthesis and Catalysis Laboratory (LSCT) as part of PRFU projects (code: B00L01UN140120220002) funded by the Ministry of Higher Education and Scientific Research of Algeria.

Declaration of Competing Interest

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

References

[1]

Chopra PG. Chalcones: a brief review. Int. J. Res. Eng. Appl. Sci. 2016, 6, 173-185.

[2]

Gouin S. Microencapsulation: industrial appraisal of existing technologies and trends. Trends Food Sci. Technol. 2004, 15, 330-347.

[3]

Li H, Chen Y, Zhang B, Niu X, Song M, Luo Z, et al. Inhibition of sortase A by chalcone prevents Listeria monocytogenes infection. Biochem. Pharmacol. 2016, 106, 19-29.

[4]

Yadav HL, Gupta P, Pawar R, Singour P, Patil U. Synthesis and biological evaluation of anti-inflammatory activity of 1,3 diphenyl propenone derivatives. Med. Chem. Res. 2011, 20, 461-465.

[5]

Ansari FL, Umbreen S, Hussain L, Makhmoor T, Nawaz SA, Lodhi MA, et al. Syntheses and biological activities of chalcone and 1,5-benzothiazepine derivatives: promising new free-radical scavengers, and esterase, urease, and α-glucosidase inhibitors. Chem. Biodivers. 2005, 2, 487-496.

[6]

Raju DB, Rao AV, Prasad YR. Hybrid sulfonylurea-linked chalconoids as antidiabetic agents: Evaluation of antihyperglycemic effects in streptozotocin-induced type 2 diabetic rats. Rasayan J. Chem. 2018, 11, 1334-1338.

[7]

Bak E, Park H, Lee C, Lee T, Woo G, Na Y, et al. Effects of novel chalcone derivatives on α-glucosidase, dipeptidyl peptidase-4 and adipocyte differentiation in vitro. BMB Rep. 2011, 44, 410-414.

[8]

Abdelmalek I. Formulation, evaluation and microbiological activity of ampicillin and amoxicillin microspheres. J. Mater. Environ. Sci. 2014, 5, 1799-1807.

[9]

Gomes MN, Muratov EN, Pereira M, Peixoto JC, Rosseto LP, Cravo PV, et al. Chalcone derivatives: Promising starting points for drug design. Molecules 2017, 22, 1210.

[10]

Fringuelli F, Pizzo F, Vittoriani C, Vaccaro L. Polystyryl-supported TBD as an efficient and reusable catalyst under solvent-free conditions. Chem. Commun. 2004, 23, 2756-2757.

[11]

Srivastava YK. Ecofriendly microwave assisted synthesis of some chalcones. Rasayan J. Chem. 2008, 1, 884-886.

[12]

Ouattara B, Simard RE, Piette G, Begin A, Holley RA. Diffusion of acetic and propionic acids from chitosan‐based antimicrobial packaging films. J. Food Sci. 2000, 65, 768-773.

[13]

Yea SD, Kirana E. Formation of polymer particles with supercritical fluids: A review. J. Supercrit. Fluid. 2005, 34, 287-308.

[14]

Abdallah R, Frikha D, Maalej S, Sassi S. Evaluation in vitro de l’activité antibacterienne et antifongique de quatre especes algales marines. J. l'Information Médicale Sfax 2019, 31, 38-44.

[15]

Schwalbe R, Steele-Moore L, Goodwin AC. Antimicrobial Susceptibility Testing Protocols; CRC Press: Boca Raton, FL, USA, 2007; Volume 56.

[16]

Pavia DL, Lampman GM, Kriz GS, Engel RG. Introduction to Organic Laboratory Techniques, 4th ed.; Brooks Cole: Pacific Grove, CA, USA, 1990.

[17]

Macías-Cortés E, Gallegos-Infante JA, Rocha-Guzmán NE, Moreno-Jiménez MR, Medina-Torres L, González-Laredo RF. Microencapsulation of phenolic compounds: Technologies and novel polymers. Revista Mexicana de Ingeniería Química 2020, 19, 491-521.

[18]

Ming L, Rouaud O, Poncelet D. Microencapsulation by solvent evaporation: State of the art for process engineering approaches. Int. J. Pharm. 2008, 363, 26-39.

[19]

Kemala T, Budianto E, Soegiyono B. Preparation and characterization of microspheres based on blend of poly (lactic acid) and poly (ɛ-caprolactone) with poly (vinyl alcohol) as emulsifier. Arab. J. Chem. 2012, 5, 103-108.

[20]

Youn RH, Dong HL, Sun HK, Young JS, Minhee Y, Jae SS. Preparation of biodegradable poly(lactic acid) microspheres containing plasmid DNA for gene delivery. J. Ind. Eng. Chem. 2010, 16, 728-733.

[21]

Zolnik BS, Burgess DJ. Evaluation of in vivo-in vitro release of dexamethasone from PLGA microspheres. J. Control. Release 2008, 127, 137-145.

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