Mechanisms of muscle repair after peripheral nerve injury by electrical stimulation combined with blood flow restriction training

Abstract

This review elucidates the impact of electrical stimulation (ES) and blood flow restriction (BFR) training on muscle function. ES induces a transformation in muscle fibers type by rearranging myosin heavy chain isoform patterns. Additionally, it influences muscle protein synthesis and degradation through specific signaling pathways such as protein kinase B/mechanistic target of rapamycin (Akt/mTOR), as well as via autophagy and the ubiquitin-proteasome system, thereby effectively maintaining muscle mass. BFR, on the other hand, restricts muscle blood flow, leading to metabolic products accumulation and localized hypoxia, which not only promotes the recruitment of fast-twitch fibers but also activates the mTOR signaling pathway, enhancing muscle protein synthesis. The combination of ES and BFR synergistically facilitates muscle protein synthesis through the mTOR pathway, thereby accelerating the recovery of muscle function following peripheral nerve injury.

Keywords

Electrical stimulation / Blood flow restriction / Muscle fibers / mTOR / Muscle protein synthesis

CRediT authorship contribution statement

Xiaolei Chu: Writing - original draft. Jiaojiao Sun: Writing - original draft. Jiajia Liang: Writing - review & editing. Wenjie Liu: Writing - review & editing. Zheng Xing: Writing - review & editing. Qi Li: Writing - review & editing. Qingwen Li: Writing - review & editing.

Declaration of competing interest

We confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome.

We confirm that the manuscript has been read and approved by all named authors and that there are no other persons who satisfied the criteria for authorship but are not listed. We further confirm that the order of authors listed in the manuscript has been approved by all of us.

We confirm that we have given due consideration to the protection of intellectual property associated with this work and that there are no impediments to publication, including the timing of publication, with respect to intellectual property. In so doing we confirm that we have followed the regulations of our institutions concerning intellectual property.

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