Correlation between daily physical activity and intestinal microbiota in perimenopausal women

Abstract

This study aimed to examine the correlation between daily physical activity levels and gut microbiota during the perimenopausal period. To explore the physiopathological traits of perimenopause women, and provide a theoretical basis for the development of menopause exercise intervention program. In this study, daily physical activity was assessed using the ActiGraph wGT3X-BT wearable sensor, and 16S rRNA sequencing was employed to analyze gut microbiota diversity and composition. Comparative analysis was conducted to evaluate the association between physical activity and specific phyla and genera in the gut microbiota, comparing perimenopausal women to youth women. The results showed perimenopausal women exhibited significantly lower levels of daily physical activity, including Kcals, metabolic equivalents (METs), and moderate-to-vigorous physical activity (MVPA), compared to youth women. The composition of the gut microbiota was markedly different between the two groups. Specifically, the abundance of Acidobacteria, Chloroflexi, Nitrospirae, and Gemmatimonadetes were lower at the phylum level (p < 0.01). Collinsella, Ruminococcus gnavus, Rothia, Haemophilus, Sphingomonas, Lactobacillales, and Lactococcus were lower at the genus level, while Phascolarctobacterium, Paraprevotella, Acinetobacter, Flavonifractor, and Intestinimonas exhibited a significant increase (p < 0.05, p < 0.01). Furthermore, a positive correlation was observed between Chloroflexi or Sphingomonas and physical activity (kcals, METs, and MVPA), while a negative correlation was found between Intestinimonas and physical activity (METs: p < 0.01, and MVPA: p < 0.05). Doubtlessly, the perimenopausal period is associated with lower levels of physical activity and distinct changes in gut microbiota. Sphingomonas may serve as a sensitive bacterium closely linked to physical activity.

Keywords

Physical activity / Intestinal microbiota / Perimenopause

Ethical approval statement

All subjects gave informed consent before participating， and the study procedure was approved by the Ethics Committee of Gaozhou Hospital of Traditional Chinese Medicine, Guangzhou University of Traditional Chinese Medicine (NO. Y [2021]16).

Authors' contributions

Yanqiu Zheng: Writing - review & editing, Writing - original draft, Data curation. Junyu Ke: Writing - review & editing, Investigation. JinBin Song: Investigation. Xuyu Li: Resources, Methodology, Investigation. Rongman Kuang: Resources, Methodology, Investigation. Haiyan Wang: Resources, Methodology, Investigation. Shuang Li: Writing - review & editing, Formal analysis, Data curation, Conceptualization. Yanwu Li: Writing - review & editing, Writing - original draft, Formal analysis, Data curation, Conceptualization.

Conflict of interest

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Acknowledgements

We are grateful to Guangzhou University for their help in providing the platform and samples. This work was supported by the Key Areas Project of Guangdong Province Educational Committee (2020ZDZX3040).

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