Smart Medicine >

2024 , Vol. 3 >Issue 2: 20240004

DOI: https://doi.org/10.1002/SMMD.20240004

Iron-doped nanozymes with spontaneous peroxidasemimic activity as a promising antibacterial therapy for bacterial keratitis

  • Xiwen Geng 1,2,3 ,
  • Nan Zhang 1,4 ,
  • Zhanrong Li 1,4 ,
  • Mengyang Zhao , 1,4 ,
  • Hongbo Zhang , 2,3 ,
  • Jingguo Li , 1,4
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  • 1. Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou, China
  • 2. Pharmaceutical Sciences Laboratory, Faculty of Science and Engineering, Åbo Akademi University, Turku, Finland
  • 3. Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland
  • 4. Henan Eye Hospital, Zhengzhou, China
zhaomyscnu@163.com
hongbo.zhang@abo.fi
lijingguo@zzu.edu.cn

Received date: 17 Mar 2024

Accepted date: 23 Apr 2024

Copyright

2024 2024 The Authors. Smart Medicine published by Wiley‐VCH GmbH on behalf of Wenzhou Institute, University of Chinese Academy of Sciences.
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Abstract

The development of non-antibiotic pharmaceuticals with biocompatible and efficient antibacterial properties is of great significance for the treatment of bacterial keratitis. In this study, we have developed antibacterial iron-doped nanozymes (Fe3+-doped nanozymes, FNEs) with distinguished capacity to fight against bacterial infections. The iron-doped nanozymes are composed of Fe3+ doped zeolitic imidazolate framework-8 (Fe/ZIF-8) and polyethylene imide (PEI), which were functionally coated on the surface of Fe/ZIF-8 and imparted the FNEs with improved water dispersibility and biocompatibility. FNEs possess a significant spontaneous peroxidase-mimic activity without the need for external stimulation, thus elevating cellular reactive oxygen species level by catalyzing local H2O2 at the infection site and resulting in bacteria damaged to death. FNEs eliminated 100% of Staphylococcus aureus within 6 h, and significantly relieved inflammation and bacterial infection levels in mice bacterial keratitis, exhibiting higher bioavailability and a superior therapeutic effect compared to conventional antibiotic eye drops. In addition, the FNEs would not generate drug resistance, suggesting that FNEs have great potential in overcoming infectious diseases caused by antimicrobial resistant bacteria.

Key words： antibacterial; antimicrobial-resistant; bacterial keratitis; nanozyme; ROS

Cite this article

Xiwen Geng , Nan Zhang , Zhanrong Li , Mengyang Zhao , Hongbo Zhang , Jingguo Li . Iron-doped nanozymes with spontaneous peroxidasemimic activity as a promising antibacterial therapy for bacterial keratitis[J]. Smart Medicine, 2024 , 3(2) : 20240004 . DOI: 10.1002/SMMD.20240004

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