Current status and challenges of biomanufacturing in India: a comprehensive review

Abstract

The biological sciences, especially biotechnology-based value-added products and services, are key players in sustainable revenue generation and influence the global bioeconomy. The study aims to understand the frameworks for historical advancements, the scope, and the emerging challenges faced by biotechnology-driven industries. Biotechnology-driven therapeutics are gaining attention due to the roles of primary and secondary metabolites, antibiotics, and antiviral vaccines in supporting human health and societal advancement. Drawing on a conceptual outline linking raw biological materials to value-added bioproducts, this study highlights bio-based resources as a cornerstone of contemporary industry and underscores their growing relevance. The review emphasizes the Indian bioeconomy, highlighting the growing significance of biomass, biotechnological innovations, and bio-derived products across multiple sectors, including biofuel production (alcohol, gasohol), enzyme-based cleaning agents, genetically modified (GM) crops, pulp and paper processing, and pharmaceutical manufacturing. This comprehensive study also delineates the economic differentiation of bioresources from conventional resources. It illustrates this with historical examples, such as the important role of India’s jute industry in shaping its national economy during the 1920s and 1930s. Biomanufacturing in India has grown steadily, with strong capabilities in vaccines, biosimilars, and large-scale fermentation-based production. However, while progress is notable, gaps remain in advanced infrastructure, scale-up capacity, and high-end innovation. In conclusion, the emerging biotechnology sectors involved in vaccine, nutraceutical, pharmaceutical, biomolecule, and personalized therapeutic production were examined, offering insights into their roles in value addition and national income generation.

Keywords

Agricultural waste / Biomass / Cottage industries / Economics / Epidemics / Policies

References

[1] Abajebal N, Barnabas J, Abebe T. Impact of RNA Enzymes and RNA Protein Complexes in Unleashing RNAInterference for Manyfold Crop Improvements: A Review. Agricultural Reviews, 2024

[2] Adesina O, Anzai IA, Avalos JL, Barstow B. Embracing Biological Solutions to the Sustainable Energy Challenge. Chem, 2017, 2: 20-51

[3] Afraz M, Muhammad F, Nisar J, Shah A, Munir S, Ali G, Ahmad A. Production of value added products from biomass waste by pyrolysis: An updated review. Waste Manage Bull, 2024, 1: 30-40

[4] Aguilar A, Twardowski T, Wohlgemuth R. Bioeconomy for sustainable development. Biotechnol J. 2019;14. https://doi.org/10.1002/biot.201800638.

[5] Akhlisah ZN, Yunus R, Abidin ZZ, Lim BY, Kania D. Pretreatment methods for an effective conversion of oil palm biomass into sugars and high-value chemicals. Biomass Bioenergy, 2021, 144: 105901

[6] AliAkbari R, Ghasemi MH, Neekzad N, Kowsari E, Ramakrishna S, Mehrali M, Marfavi Y. High value add bio-based low-carbon materials: Conversion processes and circular economy. J Clean Prod, 2021, 293: 126101

[7] Arshad U, Hassan A, Ahmad T, Naeem M, Chaudhary MT, Abbas SQ, Randhawa MA, Pimentel TC, da Cruz AG, Aadil RM. A recent glance on the valorisation of cheese whey for industrial prerogative: high-value‐added products development and integrated reutilising strategies. Int J Food Sci Technol, 2023, 58: 2001-13

[8] Bezie A, Regasa H. The role of starter culture and enzymes/ rennet for fermented dairy products manufacture- A review. Nutri Food Sci Int J 9 (2019).

[9] Bhaker S, Kaushal P. Feasibility analysis for ethanol blended fuel in India, Biofuels (2020).

[10] Boantza VD. Fermentation. Encyclopedia of Early Modern Philosophy and the Sciences, 2022, Cham, Springer International Publishing: 667-82

[11] Boswihi SS, Udo EE. Methicillin-resistant Staphylococcus aureus: An update on the epidemiology, treatment options and infection control. Curr Med Res Pract, 2018, 8: 18-24

[12] Bröring S, Thybussek V. Understanding the business model design for complex technology systems: The case of the bioeconomy. EFB Bioeconomy J, 2023, 3: 100052

[13] Bujang A, Abidin SASZ, Nizar NNA. Innovation of food products in halal supply chain worldwide. Elsevier Science; 2023.

[14] Bytyqi H, Gündüz Ergün B, Ozturk AB, Kumar G. Review of enzymatic and pretreatment methods for lignocellulosic biomass biorefinery: technical advances and economic viability, (2026). https://doi.org/10.2139/ssrn.6171466

[15] Ngwakwe C. COVID-vaccination and performance in five global stock market indexes: array, Acta Universitatis Danubius. Œconomica 17 (2021).

[16] Chavda VP, Vihol DR, Solanki HK, Apostolopoulos V. The Vaccine World of COVID-19: India’s Contribution. Vaccines (Basel), 2022, 10: 1943

[17] Chettri U, Rai AK, Thabah S, Joshi SR. Production of Malt-Based Beverages. Industrial Microbiology and Biotechnology, 2022, Singapore, Springer Singapore: 279-306

[18] Chi W-Y, Li Y-D, Huang H-C, Chan TEH, Chow S-Y, Su J-H, Ferrall L, Hung C-F, Wu T-C. COVID-19 vaccine update: vaccine effectiveness, SARS-CoV-2 variants, boosters, adverse effects, and immune correlates of protection. J Biomed Sci, 2022, 29: 82

[19] Chinthapalli R, Skoczinski P, Carus M, Baltus W, de Guzman D, Käb H, Raschka A, Ravenstijn J. Biobased Building Blocks and Polymers—Global Capacities, Production and Trends, 2018–2023. Ind Biotechnol, 2019, 15: 237-41

[20] Clauser NM, Felissia FE, Area MC, Vallejos ME. Process Design for Value-Added Products in a Biorefinery Platform from Agro and Forest Industrial Byproducts. Polym (Basel), 2023, 15: 274

[21] Clauser NM, Felissia FE, Area MC, Vallejos ME. Process Design for Value-Added Products in a Biorefinery Platform from Agro and Forest Industrial Byproducts. Polym (Basel), 2023, 15: 274

[22] Cummins MR, Burr J, Young L, Yeatts SD, Ecklund DJ, Bunnell BE, Dwyer JP, VanBuren JM. Decentralized research technology use in multicenter clinical research studies based at U.S. academic research centers. J Clin Transl Sci, 2023, 7: e250

[23] Dávila Costa JS, Guerrero DS, Romero CM. Streptomyces: connecting red-nano and grey biotechnology fields. Crit Rev Microbiol, 2022, 48: 565-76

[24] Dahiya D, Sharma H, Rai AK, Nigam PS. Application of biological systems and processes employing microbes and algae to Reduce, Recycle, Reuse (3Rs) for the sustainability of circular bioeconomy. AIMS Microbiol, 2022, 8: 83-102

[25] Das Dangol S, Hashmi MH, Saeed F, Yel I, Öztürk A, Bakhsh A. Utilizing RNA-based approaches to understand plant-insect interactions, in: 2021: pp. 393–428. https://doi.org/10.1007/978-3-030-64994-4_17

[26] Das S. The National Policy of biofuels of India – A perspective. Energy Policy, 2020, 143: 111595

[27] Das S, Ray MK, Panday D, Mishra PK. Role of biotechnology in creating sustainable agriculture. PLOS Sustain Transformation, 2023, 2: e0000069

[28] Destek MA, Sarkodie SA, Asamoah EF. Does biomass energy drive environmental sustainability? An SDG perspective for top five biomass consuming countries. Biomass Bioenergy, 2021, 149: 106076

[29] Duarah P, Haldar D, Patel AK, Dong C-D, Singhania RR, Purkait MK. A review on global perspectives of sustainable development in bioenergy generation. Bioresour Technol, 2022, 348: 126791

[30] Dutfield G. Intellectual property rights and the life science industries. Routledge; 2017. https://doi.org/10.4324/9781315252131.

[31] El-Sohaimy SA, Hussain MA. Functional Probiotic Foods Development: Trends, Concepts, and Products. Fermentation, 2023, 9: 249

[32] Fauconnier A, Nagel TE, Fauconnier C, Verbeken G, De Vos D, Merabishvili M, Pirnay J-P. The unique role that WHO could play in implementing phage therapy to combat the global antibiotic resistance crisis. Front Microbiol. 2020;11. https://doi.org/10.3389/fmicb.2020.01982.

[33] Frisvold GB, Moss SM, Hodgson A, Maxon ME. Understanding the U.S. Bioeconomy: A New Definition and Landscape. Sustainability, 2021, 13: 1627

[34] Ganesh KS, Sridhar A, Vishali S. Utilization of fruit and vegetable waste to produce value-added products: Conventional utilization and emerging opportunities-A review. Chemosphere, 2022, 287: 132221

[35] Gao S, Song W, Guo M. The Integral Role of Bioproducts in the Growing Bioeconomy. Ind Biotechnol, 2020, 16: 13-25

[36] Gargalo CL, Udugama I, Pontius K, Lopez PC, Nielsen RF, Hasanzadeh A, Mansouri SS, Bayer C, Junicke H, Gernaey KV. Towards smart biomanufacturing: a perspective on recent developments in industrial measurement and monitoring technologies for bio-based production processes. J Ind Microbiol Biotechnol, 2020, 47: 947-64

[37] Gaurav N, Sivasankari S, Kiran G, Ninawe A, Selvin J. Utilization of bioresources for sustainable biofuels: A Review. Renew Sustain Energy Rev, 2017, 73: 205-14

[38] Ghosh PK. Indian vaccines industry addressing human health challenges, (2019).

[39] Ghosh PK. Status of the Indian biopharmaceutical industry and way forward to be a dominant global player. MGM J Med Sci, 2023, 10: 317-26

[40] Glover A, Heathcote J, Krueger D. Optimal age-Based vaccination and economic mitigation policies for the second phase of the covid-19 pandemic. J Econ Dyn Control, 2022, 140: 104306

[41] Graciano RCD, Ribeiro JAT, Macêdo AKS, de Lavareda JP, de Oliveira PR, Netto JB, Nogueira LM, Machado JM, Camposda-Paz M, Giunchetti RC, Galdino AS. Recent Patents Applications in Red Biotechnology: A Mini-Review, Recent Pat. Biotechnol, 2019, 13: 170-86

[42] Gupta V, Sengupta M, Prakash J, Tripathy BC. An Introduction to Biotechnology. Basic and Applied Aspects of Biotechnology, 2017, Singapore, Springer Singapore: 1-21

[43] Han K, Yang H, Fan D, Deng J. Advances in Nanotechnology Research in Food Production. Nutr Health Nutrients, 2025, 17: 2443

[44] Harshitha T, Parinitha A, Gawali PP, Somya A, Yannam SK. Grain Processing and Baking Technology. Frontiers in Food Biotechnology, 2024, Singapore, Springer Nature Singapore: 91-119

[45] Harutyunyan M, Malfeito-Ferreira M. The Rise of Wine among Ancient Civilizations across the Mediterranean Basin. Heritage, 2022, 5: 788-812

[46] Henrich E, Dahmen N, Dinjus E, Sauer J. The Role of Biomass in a Future World without Fossil Fuels. Chem Ing Tech, 2015, 87: 1667-85

[47] Hussain S, Sharma S, Kumar A, Patil M, Kumar P, Isha A. Narain Singh, Conservation and Management of Bioresources in India. Biotechnological Innovations for Sustainable Biodiversity and Development, 2025, Boca Raton, CRC: 147-59

[48] Idris F, Ting DHR, Alonso S. An update on dengue vaccine development, challenges, and future perspectives, Expert Opin. Drug Discov, 2021, 16: 47-58

[49] Jagaba AH, Kutty SRM, Baloo L, Birniwa AH, Lawal IM, Aliyu MK, Yaro NSA, Usman AK. Combined treatment of domestic and pulp and paper industry wastewater in a rice straw embedded activated sludge bioreactor to achieve sustainable development goals. Case Stud Chem Environ Eng, 2022, 6: 100261

[50] Jagtap U, Bapat VA. Tailoring plants by gene silencing associated with small nucleic acid molecules: an update. Endocytobiosis Cell Res 27 (2016).

[51] Jakovljevic M, Wu W, Merrick J, Cerda A, Varjacic M, Sugahara T. Asian innovation in pharmaceutical and medical device industry – beyond tomorrow. J Med Econ, 2021, 24: 42-50

[52] Kardung M, Cingiz K, Costenoble O, Delahaye R, Heijman W, Lovrić M, van Leeuwen M, M’Barek R, van Meijl H, Piotrowski S, Ronzon T, Sauer J, Verhoog D, Verkerk PJ, Vrachioli M, Wesseler JHH, Zhu BX. Development of the Circular Bioeconomy: Drivers and Indicators. Sustainability, 2021, 13: 413

[53] Katz L, Chen YY, Gonzalez R, Peterson TC, Zhao H, Baltz RH. Synthetic biology advances and applications in the biotechnology industry: a perspective. J Ind Microbiol Biotechnol, 2018, 45: 449-61

[54] Kazemi Shariat Panahi H, Dehhaghi M, Guillemin GJ, Gupta VK, Lam SS, Aghbashlo M, Tabatabaei M. Bioethanol production from food wastes rich in carbohydrates. Curr Opin Food Sci, 2022, 43: 71-81

[55] Kedia AG, Kumar P, Dutta A. Value added hydrocarbons from lignin derived bio-oils: Insights from process simulations. Mater Today Proc, 2023, 72: 187-91

[56] Khan AA, Iqbal B, Jalal A, Khan KA, Al-Andal A, Khan I, Suboktagin S, Qayum A, Elboughdiri N. Advanced Molecular Approaches for Improving Crop Yield and Quality: A Review, J. Plant Growth Regul, 2024, 43: 2091-103

[57] Khunnonkwao P, Thitiprasert S, Jaiaue P, Khumrangsee K, Cheirsilp B, Thongchul N. The outlooks and key challenges in renewable biomass feedstock utilization for value-added platform chemical via bioprocesses. Heliyon, 2024, 10: e30830

[58] Khushboo KK, Dubey. Enhanced Production of Lipstatin Through NTG Treatment of Streptomyces toxytricini KD18 at 5 L Bioreactor Level. Appl Biochem Biotechnol, 2023, 195: 6881-92

[59] Khushboo M, Thakur P, Kumar D, Rajput V, Yadav N, Dhaka R, Shukla K, Kumar, Dubey. Genome-guided approaches and evaluation of the strategies to influence bioprocessing assisted morphological engineering of Streptomyces cell factories. Bioresour Technol, 2023, 376: 128836

[60] Kim HS, Kwak S-S. Crop biotechnology for sustainable agriculture in the face of climate crisis. Plant Biotechnol Rep, 2020, 14: 139-41

[61] Knorr D, Augustin MA. Preserving the food preservation legacy. Crit Rev Food Sci Nutr, 2023, 63: 9519-38

[62] Konde V. Biotechnology business models: An Indian perspective. J Commer Biotechnol, 2009, 15: 215-26

[63] Kordi M, Salami R, Bolouri P, Delangiz N, Asgari Lajayer B, van Hullebusch ED. White biotechnology and the production of bio-products. Syst Microbiol Biomanufacturing, 2022, 2: 413-29

[64] Krampis K, Wultsch C. Review of Cloud Computing Bioinformatics Solutions for Next-Gen Sequencing Data Analysis and Research2015

[65] Kulkarni PS, Padmapriyadarsini C, Vekemans J, Bavdekar A, Gupta M, Kulkarni P, Garg BS, Gogtay NJ, Tambe M, Lalwani S, Singh K, Munshi R, Meshram S, Selvavinayagam TS, Pandey K, Bhimarasetty DM, Ramakrishnan SR, Bhamare C, Dharmadhikari A, Budhawant C, Bonhomme CJ, Thakar M, Kurle SN, Kelly EJ, Gautam M, Gupta N, Panda S, Bhargava B, Poonawalla CS, Shaligram U, Kapse D, Gunale B, Kawade A, Gondhali A, Singh MP, Mohindra R, Pereiera P, Narayana Murthy MR, Raut AV, Maliye C, Kalantri A, Chaudhari VLL, Godbole CJ, Parande M, Salunke N, Palkar S, Hanumante N, Chaudhari P, Karande S, Kumbhar D, Gupta S, Mitra S, Sudharshini S, Venkatesan P, - M, Sen A, Sreegiri S, Vithanala VDP, Panneerselvam T, Nair AM, Chaudhari A, Patil S. Seropersistence of SII-ChAdOx1 nCoV-19 (COVID-19 vaccine): 6-month follow-up of a randomized, controlled, observer-blind, phase 2/3 immuno-bridging study in Indian adults. Hum Vaccin Immunother. 2024;20. https://doi.org/10.1080/21645515.2024.2304974.

[66] Kumar B. Government initiatives and policies in healthcare biotechnology, in: biotechnology in healthcare, Elsevier, 2022: pp. 303–320. https://doi.org/10.1016/B978-0-323-90042-3.00017-7

[67] Kumar D, Kumar J. Establishing BioE3 centres: catalyzing India’s biomanufacturing transformation. Front Bioeng Biotechnol. 2025;13. https://doi.org/10.3389/fbioe.2025.1681476.

[68] Kumar N, Biotechnology, improvement C. CRC, New York, 2022. https://doi.org/10.1201/9781003239932

[69] Kumar K, Gambhir G, Dass A, Tripathi AK, Singh A, Jha AK, Yadava P, Choudhary M, Rakshit S. Genetically modified crops: current status and future prospects. Planta, 2020, 251: 91

[70] Kumar S, Bhawna R, Sharma A, Gupta KK, Dubey AM, Khan R, Singhal R, Kumar A, Bharti P, Singh R, Kant V, Kumar. TiO2 based Photocatalysis membranes: An efficient strategy for pharmaceutical mineralization. Sci Total Environ, 2022, 845: 157221

[71] Kumari R, Parashar P. Exploring the Global Trend of the Sustainable Bioeconomy: An Analysis of Scientific Literature. Circular Econ Sustain, 2026, 6: 84

[72] Lalchhandama K. History of penicillin. WikiJournal Med, 2021, 8: 3

[73] Leonard MM, Cureton P, Fasano A. Nutritional Considerations in the management of gluten-related disorders * *adapted from Michelle Pietzak. Nutrition in the prevention and treatment of disease. Elsevier; 2017. pp. 893–909. https://doi.org/10.1016/B978-0-12-802928-2.00041-2.

[74] Lesk AM. Introduction to bioinformatics. 5th ed. Oxford University Press; 2019.

[75] Libbrecht MW, Noble WS. Machine learning applications in genetics and genomics. Nat Rev Genet, 2015, 16: 321-32

[76] Liu Z, de Souza TSP, Holland B, Dunshea F, Barrow C, Suleria HAR. Valorization of Food Waste to Produce Value-Added Products Based on Its Bioactive Compounds. Processes, 2023, 11: 840

[77] Lv M, Luo X, Shen Q, Lei R, Liu X, Liu E, Li Q, Chen Y. Safety, Immunogenicity, and Efficacy of COVID-19 Vaccines in Children and Adolescents: A Systematic Review. Vaccines (Basel), 2021, 9: 1102

[78] Malik KA, Maqbool A. Transgenic crops for biofortification, front. Sustain Food Syst. 2020;4. https://doi.org/10.3389/fsufs.2020.571402.

[79] Malvika G, Gupta S. Startups and the growing entrepreneurial ecosystem. J Intellect Property Rights. 2021;26. https://doi.org/10.56042/jipr.v26i1.35258.

[80] Mandeep G, Kumar Gupta P, Shukla. Insights into the resources generation from pulp and paper industry wastes: Challenges, perspectives and innovations. Bioresour Technol, 2020, 297: 122496

[81] Manohar S, Kumar S, Krishnan V, Maheshwari C, Dhaka AS, Narwal S, Nair LS, Vinutha T, Bansal N, Sureja AK, Dahuja A, Kumari S. Insights into the Genetic Improvement of Carrot (Daucus carota L. Genetic Engineering of Crop Plants for Food and Health Security, 2024, Singapore, Springer Nature Singapore: 185-203

[82] Mboowa D. A review of the traditional pulping methods and the recent improvements in the pulping processes. Biomass Convers Biorefin, 2024, 14: 1-12

[83] Mboumboue E, Njomo D. Biomass resources assessment and bioenergy generation for a clean and sustainable development in Cameroon. Biomass Bioenergy, 2018, 118: 16-23

[84] Modak M, Nyayanit N, Sivaram A, Patil N. The recombinant DNA technology era, in: 2022: pp. 1–14. https://doi.org/10.1007/978-3-030-96851-9_1

[85] Monteiro MG, Martins CB, Sanchez ZM, Rehm J, Shield K, Falade R, MacDiarmid J, Trangenstein P. Assessing Sustainable Development Goal Target Indicator 3.5.2: Trends in alcohol per capita consumption in the Americas 1990–2016. Revista Panam de Salud Pública, 2021, 45: 1

[86] Panda B, Dhar PK. Building biofoundry India: challenges and path forward. Synth Biol. 2021;6. https://doi.org/10.1093/synbio/ysab015.

[87] Panda S, Singh PK, Mishra S, Mitra S, Pattnaik P, Das Adhikary S, Mohapatra RK. Indian Biosimilars and Vaccines at Crossroads–Replicating the Success of Pharmagenerics. Vaccines (Basel), 2023, 11: 110

[88] Patel AK, Dong C-D, Chen C-W, Pandey A, Singhania RR. Production, purification, and application of microbial enzymes. Biotechnology of microbial enzymes. Elsevier; 2023. pp. 25–57. https://doi.org/10.1016/B978-0-443-19059-9.00019-0.

[89] Persson F, Bodegard J, Lahtela JT, Nyström T, Jørgensen ME, Jensen ML, Gulseth HL, Thuresson M, Hoti F, Nathanson D, Norhammar A, Birkeland KI, Eriksson JG, Eriksson JW. Different patterns of second-line treatment in type 2 diabetes after metformin monotherapy in Denmark, Finland, Norway and Sweden (D360 Nordic): a multinational observational study. Endocrinol Diabetes Metab. 2018;1. https://doi.org/10.1002/edm2.36.

[90] Petrie LT. Raising the dead: experimental and metaphysical approaches of rehydrating ancient mummified human tissue. Macquarie University; 2020.

[91] Premetis G, Marugas P, Fanos G, Vlachakis D, Chronopoulou EG, Perperopoulou F, Dubey KK, Shukla P, Foudah AI, Muharram MM, Aldawsari MF, Papageorgiou AC, Labrou NE. The Interaction of the Microtubule Targeting Anticancer Drug Colchicine with Human Glutathione Transferases. Curr Pharm Des, 2020, 26: 5205-12

[92] Directorate-general for research and innovation. Top 20 innovative bio-based products: R&I policy support study. Publications Office of the European Union; 2019.

[93] Ray RC, Paramithiotis S, Thekkangil A, Nethravathy V, Rai AK, Martin JGP. Food Fermentation and Its Relevance in the Human History. Trending Topics on Fermented Foods, 2024, Cham, Springer Nature Switzerland: 1-57

[94] Raza A. Genetically modified crops: benefits, risks, and regulatory perspectives. Frontiers in Agriculture; 2024.

[95] S. GÜRKÖK, Microbial enzymes in detergents: a review. Int J Sci Eng Res 10 (2019).

[96] Sahu B, Perepu I. Kiran Mazumdar-Shaw: the woman behind the success of Biocon. Case Women. 2022;1–37. https://doi.org/10.1108/CFW.2022.000006.

[97] Salalli R, Dange JR, Dhiman S, Sharma T. Vaccines development in India: advances, regulation, and challenges. Clin Exp Vaccine Res, 2023, 12: 193

[98] Santos-Beneit F. What is the role of microbial biotechnology and genetic engineering in medicine? Microbiologyopen. 2024;13. https://doi.org/10.1002/mbo3.1406.

[99] Scillitoe JL, Birasnav M. Ease of market entry of Indian startups: formal and informal institutional influences. South Asian J Bus Stud, 2022, 11: 195-215

[100] Segers B, Nimmegeers P, Spiller M, Tofani G, Jasiukaitytė-Grojzdek E, Dace E, Kikas T, Marchetti JM, Rajić M, Yildiz G, Billen P. Lignocellulosic biomass valorisation: a review of feedstocks, processes and potential value chains and their implications for the decision-making process. RSC Sustain, 2024, 2: 3730-49

[101] Sharma R. Locating food in the cultural history of Sikkim: a study of fermented drinks. Sikkim University; 2021.

[102] Sharma S, Tiwari RK, Sagar V. C. Maharana, Soil- and tuber-borne diseases of potato, in: approaches for potato crop improvement and stress management, Springer Nature Singapore, Singapore, 2024: pp. 179–231. https://doi.org/10.1007/978-981-97-1223-6_7

[103] Singh VK. Policy and regulatory changes for a successful startup revolution: experiences from the startup action plan in India, in: 2021: pp. 33–67. https://doi.org/10.1142/9789811235825_0002

[104] Sme O, Papers E, Montegu J, Saporito NF, Polakiewicz Z. 2025 D4SME survey the evolution of the biotechnology sector implications for FDI and SME linkages across Europe OECD SME and entrepreneurship papers, 2026. www.oecd.org

[105] Sodhi AS, Sharma N, Bhatia S, Verma A, Soni S, Batra N. Insights on sustainable approaches for production and applications of value added products. Chemosphere, 2022, 286: 131623

[106] Sorokan A, Gabdrakhmanova V, Kuramshina Z, Khairullin R, Maksimov I. Plant-Associated Bacillus thuringiensis and Bacillus cereus: Inside Agents for Biocontrol and Genetic Recombination in Phytomicrobiome. Plants, 2023, 12: 4037

[107] Sperkova K, Anderson P, Llopis EJ. Alcohol policy measures are an ignored catalyst for achievement of the sustainable development goals. PLoS ONE, 2022, 17: e0267010

[108] Srivastava S, Tyagi R, Sharma S. Seed biopriming as a promising approach for stress tolerance and enhancement of crop productivity: a review. J Sci Food Agric, 2024, 104: 1244-57

[109] Srivastava S, Chandramouli A, Gupta P, Manzer AR, Choudhury R, Reddy DS, Yazdani SS, Kamat SS, Mohanty D, Nandicoori VK, Gokhale RS. Novel routes for bioproduction of delta lactone aroma compounds. Metab Eng, 2026, 94: 295-304

[110] Suresh N, Chandan SR, Bioeconomy report india bioeconomy. Report 2026, 2026. https://www.birac.nic.in/webcontent/IBER_2026.pdf (accessed April 20, 2026).

[111] Temesgen B. Combining ability and heterosis in plant improvement. Open J Plant Sci. 2021;108–17. https://doi.org/10.17352/ojps.000043.

[112] Thatoi HN, Chattaraj S, Mishra RR, Das Mohapatra PK, Mohapatra S. Contributions of biotechnology industries of India to global bioeconomy: an overview. 3 Biotech, 2025, 15: 46

[113] microlit. Top 10 Biotechnology companies in the USA, (2021). https://www.microlit.us/top-10-bio-technology-companies-in-the-usa/ (accessed January 21, 2026).

[114] Tse V, Schweizer L. Global or local: The future of biotech, Drug Discov. Today, 2023, 28: 103528

[115] Uppal A, Chakrabarti R, Chirmule N, Rathore A, Atouf F. Biopharmaceutical Industry Capability Building in India: Report from a Symposium. J Pharm Innov, 2022, 17: 1555-62

[116] Vala AK, Sachaniya BK, Dave BP. Marine fungal white biotechnology: an ecological and industrial perspective, in: 2019: pp. 483–503. https://doi.org/10.1007/978-3-030-10480-1_15

[117] Value-addition in food products and processing through enzyme technology. Elsevier, 2022. https://doi.org/10.1016/C2020-0-03025-2

[118] van den Boogaard J, de Gier B, de Oliveira Bressane P, Lima S, Desai HE, de Melker SJM, Hahné IK, Veldhuijzen. Immunogenicity, duration of protection, effectiveness and safety of rubella containing vaccines: A systematic literature review and meta-analysis. Vaccine, 2021, 39: 889-900

[119] Visciano P, Schirone M. Update on Biogenic Amines in Fermented and Non-Fermented Beverages. Foods, 2022, 11: 353

[120] Vishal S, Banyal AK, Shukla A, Kumari A, Kumar A, Khatak A, Luthra, Sunil M, Kumar. Effect of Modification on Quality Parameters of Jackfruit (Atrocarpus heterophyllus) Seed Starch to Valorize its Food Potential and In-Silico Investigation of the Pharmacological Compound Against Salmonellosis. Waste Biomass Valorization, 2023, 14: 1597-610

[121] West JB. Joseph Black, carbon dioxide, latent heat, and the beginnings of the discovery of the respiratory gases. Am J Physiology-Lung Cell Mol Physiol, 2014, 306: L1057-63

[122] Xia Y, Li Y, Shen W, Yang H, Chen X. CRISPR-Cas Technology for Bioengineering Conventional and Non-Conventional Yeasts: Progress and New Challenges. Int J Mol Sci, 2023, 24: 15310

[123] Xu Q, Xu B, Wang P, He Y. Bundling strategies for complementary products in a horizontal supply chain. Kybernetes, 2018, 47: 1158-77

[124] Zhang M, Zhang Y, Yang C, Ma C, Tang J. Enzyme-inorganic hybrid nanoflowers: Classification, synthesis, functionalization and potential applications. Chem Eng J, 2021, 415: 129075

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