Reprogramming central carbon metabolism for the efficient de novo biosynthesis of D-chiro-inositol in Escherichia coli

Kaiyang Zhao , Yaokang Wu , Xueqin Lv , Jianghua Li , Long Liu , Guocheng Du , Jian Chen , Yanfeng Liu

Systems Microbiology and Biomanufacturing ›› 2026, Vol. 6 ›› Issue (2) : 52

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Systems Microbiology and Biomanufacturing ›› 2026, Vol. 6 ›› Issue (2) :52 DOI: 10.1007/s43393-026-00458-4
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Reprogramming central carbon metabolism for the efficient de novo biosynthesis of D-chiro-inositol in Escherichia coli
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Escherichia coli / Metabolic engineering / D-chiro-inositol / Central metabolic regulation / Fed-batch fermentation

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Kaiyang Zhao, Yaokang Wu, Xueqin Lv, Jianghua Li, Long Liu, Guocheng Du, Jian Chen, Yanfeng Liu. Reprogramming central carbon metabolism for the efficient de novo biosynthesis of D-chiro-inositol in Escherichia coli. Systems Microbiology and Biomanufacturing, 2026, 6(2): 52 DOI:10.1007/s43393-026-00458-4

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Funding

National Key Research and Development Program for Food Nutrition and Safety(2023YFF1104100)

National Natural Science Foundation of China(32300064)

Scientific Research Innovation Capability Support Project for Young Faculty(ZYGXQNJSKYCXNLZCXM-A6)

the Fundamental Research Funds for the Central Universities(JUSRP622028)

Research Program of State Key Laboratory of Food Science and Resources, Jiangnan University(SKLF-ZZB-202405)

Jiangsu Basic Research Center for Synthetic Biology(20233003)

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Jiangnan University

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