Enhanced substrate tolerance of l-amino acid deaminase by reshaping substrate binding pocket for phenylpyruvic acid production

Kai Chu , Yingjia Tong , Qingbo Deng , Xiaomei Zhang , Jinsong Shi , Zhenghong Xu , Hui Li

Systems Microbiology and Biomanufacturing ›› 2026, Vol. 6 ›› Issue (2) : 49

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Systems Microbiology and Biomanufacturing ›› 2026, Vol. 6 ›› Issue (2) :49 DOI: 10.1007/s43393-026-00448-6
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Enhanced substrate tolerance of l-amino acid deaminase by reshaping substrate binding pocket for phenylpyruvic acid production
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Phenylpyruvate / Substrate tolerance / l-amino acid deaminase / Binding pocket remodeling / Whole-cell biocatalysis

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Kai Chu, Yingjia Tong, Qingbo Deng, Xiaomei Zhang, Jinsong Shi, Zhenghong Xu, Hui Li. Enhanced substrate tolerance of l-amino acid deaminase by reshaping substrate binding pocket for phenylpyruvic acid production. Systems Microbiology and Biomanufacturing, 2026, 6(2): 49 DOI:10.1007/s43393-026-00448-6

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Funding

Fundamental Research Funds for the Central Universities(Grant JUSRP202504023)

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Jiangnan University

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