Technological Innovation in Syngas Fermentation and Prospects for Industrial Application

Abstract

In the context of the global carbon neutrality strategy, syngas fermentation technology has emerged as a research hotspot in biomanufacturing because it can recover and convert industrial exhaust gas. Relying on the Wood-Ljungdahl pathway in acetogens, this technology converts gaseous substrates, such as CO and CO2, into high-value-added chemicals. However, bottlenecks including low gas-liquid mass-transfer efficiency and challenges with scale-up, severely limit its industrialization. The review focuses on core research-level topics, including the key enzymatic mechanisms of acetogens, metabolic regulation strategies, and high-throughput strain construction technologies; systematically analyzes the feed gas pretreatment process, design principles of large-scale reactors, fermentation process optimization, efficient product separation and purification technologies, and full-process integration at the process level; and summarizes techno-economic analysis and global policy support for industrial application. Finally, it thoroughly analyzes the core challenges of this technology across core mechanisms, engineering operations, economic markets, and industrial chain coordination, and outlines the future development direction of the technology. By systematically collating the syngas fermentation technology system and its industrialization bottlenecks, this review provides references for its industrialization. It is positioned to boost the economic viability and industrial appeal of the CCUS system, acting as a pivotal engine for advancing deep industrial decarbonization and fostering emerging green industries.

Keywords

Carbon neutrality / Syngas fermentation / Acetogens / Wood-Ljungdahl pathway / Scale-up

Statement of the Use of Generative AI and AI-Assisted Technologies in the Writing Process

During the preparation of this manuscript, the authors used DeepSeek to improve the grammar and syntax. After using this tool/service, the authors reviewed and edited the content as needed and take full responsibility for the content of the published article.

Author Contributions

Investigation, X.L.; Writing—Original Draft Preparation, N.L.; Writing—Review & Editing, X.B.; Project Administration, M.Y. and R.W.; Funding Acquisition, W.C.

Ethics Statement

Not applicable for studies not involving humans or animals.

Informed Consent Statement

Not applicable for studies not involving humans.

Data Availability Statement

As this article is a review paper, no original research data were generated. All information and data cited in this study were obtained from the published literature.

Funding

This work was supported by the National Key Research and Development Program of China (2024YFA0918100).

Declaration of Competing Interest

The authors declare no conflicts of interest. The authors are employees of Beijing Shougang LangzaTech Technology Co., Ltd; however, the company had no role in the study design, data collection, data analysis, decision to publish, or preparation of the manuscript.

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