Graphene Oxide/Chitosan/Calcium Silicate Aerogels for Hemostasis and Infectious Wound Healing

Abstract

Uncontrolled hemorrhage is still the great obstacle for saving life during accident or surgery. In addition, hemostatic materials integrating with both rapid hemostasis and wound healing functions are of great significance in clinic. In this work, we successfully developed graphene oxide/chitosan/calcium silicate aerogels with good hemostasis, anti-bacteria and wound healing abilities. The porous lamellar structure with interconnected channels were constructed in aerogels, which enabled the rapid liquid-absorbing capacity and certain elasticity. Moreover, the graphene oxide/chitosan/calcium silicate aerogels exhibited good blood clotting ability in vitro and fast stop bleeding effect in vivo, far exceeding the hemostatic effect of gauze. Additionally, the graphene oxide/chitosan/calcium silicate aerogels could not only accumulate blood cells to promote primary hemostasis, but also activate the intrinsic pathway of coagulation during second hemostasis owing to the graphene oxide and bioactive components (Ca and Si ions). For the repairing of infectious skin wounds, such aerogels could inhibit inflammation after photothermal therapy at early stage and achieve high healing quality after 14 days. These multifunctional aerogels are promising biomaterials for uncontrolled hemorrhage and subsequently tissue skin tissue healing of emergency trauma.

Keywords

graphene oxide / hemostatic aerogels / anti-bacteria / wound healing