Specific Brain Activity During Theory of Mind Tasks in Autistic Individuals: A Meta-Analysis of fMRI Studies

Hanran Li; Yihui Wang; Lei Chang; Li Yi; Lai Na Siu; Juan Zhang

doi:10.1002/pchj.70060

Psych Journal ›› 2026, Vol. 15 ›› Issue (1) :e70060 DOI: 10.1002/pchj.70060

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Specific Brain Activity During Theory of Mind Tasks in Autistic Individuals: A Meta-Analysis of fMRI Studies

Hanran Li ¹^,²
, Yihui Wang ¹^,³
, Lei Chang ²
, Li Yi ⁴^,⁵
, Lai Na Siu ¹
, Juan Zhang ¹^,³

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Abstract

Autistic individuals exhibit differences in Theory of Mind (ToM) compared to neurotypical (NT) individuals. The aim of this study was to meta-analyse the neural correlates that contributed to the manifestation of the expression differences in ToM between autistic individuals and the NT population. A total of 328 autistic participants and 314 NT participants from 18 studies were included. We adopted Activation Network Mapping, which is a novel neuroimaging meta-analysis method based on activation seeds and functional connectivity to identify brain networks, to investigate how the ToM network of the autistic group differed from that of the NT group. The thalamus and precuneus robustly participated in the ToM network of the autistic group. Moreover, the temporoparietal junction and the right hemisphere of the limbic system, especially the thalamus, caudate, and cingulum, were less involved in the autistic group's ToM network, compared to the NT group. Our findings provide the first quantitative evidence supportive of the distinct patterns in the ToM brain network in the autistic population. The current findings indicate that the primary difference in ToM task performance in autistic individuals may stem from altered information processing mechanisms rather than deficits in core ToM abilities.

Keywords

activation network mapping / autism / fMRI / meta-analysis / theory of mind

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Hanran Li, Yihui Wang, Lei Chang, Li Yi, Lai Na Siu, Juan Zhang. Specific Brain Activity During Theory of Mind Tasks in Autistic Individuals: A Meta-Analysis of fMRI Studies. Psych Journal, 2026, 15(1): e70060 DOI:10.1002/pchj.70060

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References

Publishing order | Descend order by publishing year | Descend order by cited within

[1]	Adolphs, R., L. Sears, and J. Piven. 2001. “Abnormal Processing of Social Information From Faces in Autism.” Journal of Cognitive Neuroscience 13, no. 2: 232–240. https://doi.org/10.1162/089892901564289.

[2]	Alaerts, K., S. P. Swinnen, and N. Wenderoth. 2017. “Neural Processing of Biological Motion in Autism: An Investigation of Brain Activity and Effective Connectivity.” Scientific Reports 7, no. 1: 5612. https://doi.org/10.1038/s41598-017-05786-z.

[3]	American Psychiatric Association. 2013. Diagnostic and Statistical Manual of Mental Disorders: DSM-5. Vol. 5. American psychiatric association. https://doi.org/10.1176/appi.books.9780890425596.

[4]	Aoki, Y., S. Cortese, and M. Tansella. 2015. “Neural Bases of Atypical Emotional Face Processing in Autism: A Meta-Analysis of fMRI Studies.” World Journal of Biological Psychiatry 16, no. 5: 291–300. https://doi.org/10.3109/15622975.2014.957719.

[5]	Bachevalier, J., and K. A. Loveland. 2006. “The Orbitofrontal-Amygdala Circuit and Self-Regulation of Social-Emotional Behavior in Autism.” Neuroscience and Biobehavioral Reviews 30, no. 1: 97–117. https://doi.org/10.1016/j.neubiorev.2005.07.002.

[6]	Bamiou, D. E., F. E. Musiek, and L. M. Luxon. 2003. “The Insula (Island of Reil) and Its Role in Auditory Processing. Literature Review.” Brain Research. Brain Research Reviews 42, no. 2: 143–154. https://doi.org/10.1016/s0165-0173(03)00172-3.

[7]	Barbas, H. 2007. “Flow of Information for Emotions Through Temporal and Orbitofrontal Pathways.” Journal of Anatomy 211, no. 2: 237–249. https://doi.org/10.1111/j.1469-7580.2007.00777.x.

[8]

Bardi, L., C. Desmet, A. Nijhof, J. R. Wiersema, and M. Brass. 2017. “Brain Activation for Spontaneous and Explicit False Belief Tasks Overlaps: New fMRI Evidence on Belief Processing and Violation of Expectation.” Social Cognitive and Affective Neuroscience 12, no. 3: 391–400. https://doi.org/10.1093/scan/nsw143.

[9]	Baron-Cohen, S. 1989. “The Autistic Child's Theory of Mind: A Case of Specific Developmental Delay.” Journal of Child Psychology and Psychiatry 30, no. 2: 285–297. https://doi.org/10.1111/j.1469-7610.1989.tb00241.x.

[10]	Baron-Cohen, S., A. M. Leslie, and U. Frith. 1985. “Does the Autistic Child Have a “Theory of Mind”?” Cognition 21, no. 1: 37–46. https://doi.org/10.1016/0010-0277(85)90022-8.

[11]	Beer, J. S., O. P. John, D. Scabini, and R. T. Knight. 2006. “Orbitofrontal Cortex and Social Behavior: Integrating Self-Monitoring and Emotion-Cognition Interactions.” Journal of Cognitive Neuroscience 18, no. 6: 871–879. https://doi.org/10.1162/jocn.2006.18.6.871.

[12]	Black, M. H., N. T. M. Chen, K. K. Iyer, et al. 2017. “Mechanisms of Facial Emotion Recognition in Autism Spectrum Disorders: Insights From Eye Tracking and Electroencephalography.” Neuroscience and Biobehavioral Reviews 80: 488–515. https://doi.org/10.1016/j.neubiorev.2017.06.016.

[13]	Boccadoro, S., E. Cracco, A. R. Hudson, et al. 2019. “Defining the Neural Correlates of Spontaneous Theory of Mind (ToM): An fMRI Multi-Study Investigation.” NeuroImage 203: 116193. https://doi.org/10.1016/j.neuroimage.2019.116193.

[14]

Broekhof, E., L. Ketelaar, L. Stockmann, A. van Zijp, M. G. Bos, and C. Rieffe. 2015. “The Understanding of Intentions, Desires and Beliefs in Young Children With Autism Spectrum Disorder.” Journal of Autism and Developmental Disorders 45, no. 7: 2035–2045. https://doi.org/10.1007/s10803-015-2363-3.

[15]	Brothers, L. 1990. “The Neural Basis of Primate Social Communication.” Motivation and Emotion 14, no. 2: 81–91. https://doi.org/10.1007/Bf00991637.

[16]	Brothers, L. 2002. “The Social Brain: A Project for Integrating Primate Behavior and Neurophysiology in a New Domain.” In Foundations in Social Neuroscience, edited by J. T. Cacioppo, G. G. Berntson, R. Adolphs, et al., 367–386. MIT Press. https://doi.org/10.7551/mitpress/3077.003.0029.

[17]	Brownell, H., R. Griffin, E. Winner, O. Friedman, and F. Happé. 2000. “Cerebral Lateralization and Theory of Mind.” In Understanding Other Minds, edited by S. Baron-Cohen, H. Tager-Flusberg, and D. J. Cohen, vol. 2, 306–333. OUP Oxford.

[18]	Cabanis, M., M. Pyka, S. Mehl, et al. 2013. “The Precuneus and the Insula in Self-Attributional Processes.” Cognitive, Affective, & Behavioral Neuroscience 13, no. 2: 330–345. https://doi.org/10.3758/s13415-012-0143-5.

[19]	Carpenter, M., B. F. Pennington, and S. J. Rogers. 2001. “Understanding of Others' Intentions in Children With Autism.” Journal of Autism and Developmental Disorders 31, no. 6: 589–599. https://doi.org/10.1023/a:1013251112392.

[20]	Carrington, S. J., and A. J. Bailey. 2009. “Are There Theory of Mind Regions in the Brain? A Review of the Neuroimaging Literature.” Human Brain Mapping 30, no. 8: 2313–2335. https://doi.org/10.1002/hbm.20671.

[21]	Carter, E. J., D. L. Williams, N. J. Minshew, and J. F. Lehman. 2012. “Is He Being Bad? Social and Language Brain Networks During Social Judgment in Children With Autism.” PLoS One 7, no. 10: e47241. https://doi.org/10.1371/journal.pone.0047241.

[22]	Cattaneo, L., M. Fabbri-Destro, S. Boria, et al. 2007. “Impairment of Actions Chains in Autism and Its Possible Role in Intention Understanding.” Proceedings of the National Academy of Sciences of the United States of America 104, no. 45: 17825–17830. https://doi.org/10.1073/pnas.0706273104.

[23]	Cavanna, A. E., and M. R. Trimble. 2006. “The Precuneus: A Review of Its Functional Anatomy and Behavioural Correlates.” Brain 129, no. 3: 564–583. https://doi.org/10.1093/brain/awl004.

[24]

Clausi, S., G. Olivito, L. Siciliano, et al. 2021. “The Cerebellum Is Linked to Theory of Mind Alterations in Autism. A Direct Clinical and MRI Comparison Between Individuals With Autism and Cerebellar Neurodegenerative Pathologies.” Autism Research 14, no. 11: 2300–2313. https://doi.org/10.1002/aur.2593.

[25]	Cohen, A., L. Soussand, P. McManus, and M. Fox. 2020. “GSP1000 Preprocessed Connectome Version V3 Harvard Dataverse.” https://doi.org/10.7910/DVN/ILXIKS.

[26]	Constable, P. A., J. A. Solomon, S. B. Gaigg, and D. M. Bowler. 2010. “Crowding and Visual Search in High Functioning Adults With Autism Spectrum Disorder.” Clinical Optometry 2: 93–103. https://doi.org/10.2147/OPTO.S11476.

[27]	Couto, B., L. Sedeño, L. A. Sposato, et al. 2013. “Insular Networks for Emotional Processing and Social Cognition: Comparison of Two Case Reports With Either Cortical or Subcortical Involvement.” Cortex 49, no. 5: 1420–1434. https://doi.org/10.1016/j.cortex.2012.08.006.

[28]	Dadario, N. B., and M. E. Sughrue. 2023. “The Functional Role of the Precuneus.” Brain 146, no. 9: 3598–3607. https://doi.org/10.1093/brain/awad181.

[29]	Dahl, C. D., N. K. Logothetis, and C. Kayser. 2010. “Modulation of Visual Responses in the Superior Temporal Sulcus by Audio-Visual Congruency.” Frontiers in Integrative Neuroscience 4: 10. https://doi.org/10.3389/fnint.2010.00010.

[30]	Dakin, S., and U. Frith. 2005. “Vagaries of Visual Perception in Autism.” Neuron 48, no. 3: 497–507. https://doi.org/10.1016/j.neuron.2005.10.018.

[31]	Dalton, K. M., B. M. Nacewicz, T. Johnstone, et al. 2005. “Gaze Fixation and the Neural Circuitry of Face Processing in Autism.” Nature Neuroscience 8, no. 4: 519–526. https://doi.org/10.1038/nn1421.

[32]	de la Vega, A., L. J. Chang, M. T. Banich, T. D. Wager, and T. Yarkoni. 2016. “Large-Scale Meta-Analysis of Human Medial Frontal Cortex Reveals Tripartite Functional Organization.” Journal of Neuroscience 36, no. 24: 6553–6562. https://doi.org/10.1523/JNEUROSCI.4402-15.2016.

[33]	Demetriou, E. A., A. Lampit, D. S. Quintana, et al. 2018. “Autism Spectrum Disorders: A Meta-Analysis of Executive Function.” Molecular Psychiatry 23, no. 5: 1198–1204. https://doi.org/10.1038/mp.2017.75.

[34]

Denny, B. T., H. Kober, T. D. Wager, and K. N. Ochsner. 2012. “A Meta-Analysis of Functional Neuroimaging Studies of Self- and Other Judgments Reveals a Spatial Gradient for Mentalizing in Medial Prefrontal Cortex.” Journal of Cognitive Neuroscience 24, no. 8: 1742–1752. https://doi.org/10.1162/jocn_a_00233.

[35]	Desaunay, P., B. Guillery, E. Moussaoui, F. Eustache, D. M. Bowler, and F. Guenole. 2023. “Brain Correlates of Declarative Memory Atypicalities in Autism: A Systematic Review of Functional Neuroimaging Findings.” Molecular Autism 14: 2. https://doi.org/10.1186/s13229-022-00525-2.

[36]	Dubey, I., D. Ropar, and A. F. D. Hamilton. 2015. “Measuring the Value of Social Engagement in Adults With and Without Autism.” Molecular Autism 6: 35. https://doi.org/10.1186/s13229-015-0031-2.

[37]	Dufour, N., E. Redcay, L. Young, et al. 2013. “Similar Brain Activation During False Belief Tasks in a Large Sample of Adults With and Without Autism.” PLoS One 8, no. 9: e75468.

[38]	Engen, H. G., and M. C. Anderson. 2018. “Memory Control: A Fundamental Mechanism of Emotion Regulation.” Trends in Cognitive Sciences 22, no. 11: 982–995. https://doi.org/10.1016/j.tics.2018.07.015.

[39]	Fan, Y. T., C. Chen, S. C. Chen, J. Decety, and Y. Cheng. 2014. “Empathic Arousal and Social Understanding in Individuals With Autism: Evidence From fMRI and ERP Measurements.” Social Cognitive and Affective Neuroscience 9, no. 8: 1203–1213. https://doi.org/10.1093/scan/nst101.

[40]	Federici, A., V. Parma, M. Vicovaro, L. Radassao, L. Casartelli, and L. Ronconi. 2020. “Anomalous Perception of Biological Motion in Autism: A Conceptual Review and Meta-Analysis.” Scientific Reports 10, no. 1: 4576. https://doi.org/10.1038/s41598-020-61252-3.

[41]	Fletcher-Watson, S., F. McConnell, E. Manola, and H. McConachie. 2014. “Interventions Based on the Theory of Mind Cognitive Model for Autism Spectrum Disorder (ASD).” Cochrane Database of Systematic Reviews 2014, no. 3: CD008785. https://doi.org/10.1002/14651858.CD008785.pub2.

[42]	Focquaert, F., and S. M. Platek. 2006. “Social Cognition and the Evolution of Self-Awareness.” In Evolutionary Cognitive Neuroscience, edited by S. Platek, T. Shackelford, and J. Keenan, 457–497. MIT Press.

[43]	Frith, C. D., and U. Frith. 2006. “The Neural Basis of Mentalizing.” Neuron 50, no. 4: 531–534. https://doi.org/10.1016/j.neuron.2006.05.001.

[44]	Frith, C. D., and U. Frith. 2012. “Mechanisms of Social Cognition.” Annual Review of Psychology 63, no. 1: 287–313. https://doi.org/10.1146/annurev-psych-120710-100449.

[45]	Gasquoine, P. G. 2014. “Contributions of the Insula to Cognition and Emotion.” Neuropsychology Review 24, no. 2: 77–87. https://doi.org/10.1007/s11065-014-9246-9.

[46]	Geng, C., S. Wang, Z. Li, et al. 2022. “Resting-State Functional Network Topology Alterations of the Occipital Lobe Associated With Attention Impairment in Isolated Rapid Eye Movement Behavior Disorder.” Frontiers in Aging Neuroscience 14: 844483. https://doi.org/10.3389/fnagi.2022.844483.

[47]	Georgescu, A. L., B. Kuzmanovic, L. Schilbach, et al. 2013. “Neural Correlates of “Social Gaze” Processing in High-Functioning Autism Under Systematic Variation of Gaze Duration.” NeuroImage: Clinical 3: 340–351. https://doi.org/10.1016/j.nicl.2013.08.014.

[48]	Goldberg, I. I., M. Harel, and R. Malach. 2006. “When the Brain Loses Its Self: Prefrontal Inactivation During Sensorimotor Processing.” Neuron 50, no. 2: 329–339. https://doi.org/10.1016/j.neuron.2006.03.015.

[49]

Gong, X. Y., X. Li, Q. D. Wang, et al. 2021. “Comparing Visual Preferences Between Autism Spectrum Disorder (ASD) and Normal Children to Explore the Characteristics of Visual Preference of ASD Children by Improved Visual Preference Paradigm: A Case-Control Study.” Translational Pediatrics 10, no. 8: 2006–2015. https://doi.org/10.21037/tp-21-294.

[50]	Graff-Radford, J., L. Williams, D. T. Jones, and E. E. Benarroch. 2017. “Caudate Nucleus as a Component of Networks Controlling Behavior.” Neurology 89, no. 21: 2192–2197. https://doi.org/10.1212/Wnl.0000000000004680.

[51]	Greene, D. J., N. Colich, M. Iacoboni, E. Zaidel, S. Y. Bookheimer, and M. Dapretto. 2011. “Atypical Neural Networks for Social Orienting in Autism Spectrum Disorders.” NeuroImage 56, no. 1: 354–362. https://doi.org/10.1016/j.neuroimage.2011.02.031.

[52]	Greimel, E., M. Schulte-Rüther, T. Kircher, et al. 2010. “Neural Mechanisms of Empathy in Adolescents With Autism Spectrum Disorder and Their Fathers.” NeuroImage 49, no. 1: 1055–1065. https://doi.org/10.1016/j.neuroimage.2009.07.057.

[53]	Hadjikhani, N., N. R. Zürcher, O. Rogier, et al. 2014. “Emotional Contagion for Pain is Intact in Autism Spectrum Disorders.” Translational Psychiatry 4, no. 1: e343. https://doi.org/10.1038/tp.2013.113.

[54]	Hardan, A. Y., N. J. Minshew, N. M. Melhem, et al. 2008. “An MRI and Proton Spectroscopy Study of the Thalamus in Children With Autism.” Psychiatry Research 163, no. 2: 97–105. https://doi.org/10.1016/j.pscychresns.2007.12.002.

[55]	Haupt, C., and A. B. Huber. 2008. “How Axons See Their Way—Axonal Guidance in the Visual System.” Frontiers in Bioscience-Landmark 13, no. 13: 3136–3149. https://doi.org/10.2741/2915.

[56]	Ho, M. K., R. Saxe, and F. Cushman. 2022. “Planning With Theory of Mind.” Trends in Cognitive Sciences 26, no. 11: 959–971. https://doi.org/10.1016/j.tics.2022.08.003.

[57]	Hoffmann, E., C. Bruck, B. Kreifelts, T. Ethofer, and D. Wildgruber. 2016. “Reduced Functional Connectivity to the Frontal Cortex During Processing of Social Cues in Autism Spectrum Disorder.” Journal of Neural Transmission (Vienna) 123, no. 8: 937–947. https://doi.org/10.1007/s00702-016-1544-3.

[58]	Holt, R. J., L. R. Chura, M. C. Lai, et al. 2014. “'Reading the Mind in the Eyes': An fMRI Study of Adolescents With Autism and Their Siblings.” Psychological Medicine 44, no. 15: 3215–3227. https://doi.org/10.1017/S0033291714000233.

[59]	Hus, Y., and O. Segal. 2021. “Challenges Surrounding the Diagnosis of Autism in Children.” Neuropsychiatric Disease and Treatment 17: 3509–3529. https://doi.org/10.2147/NDT.S282569.

[60]	Ibanez, A., E. Gleichgerrcht, and F. Manes. 2010. “Clinical Effects of Insular Damage in Humans.” Brain Structure & Function 214, no. 5–6: 397–410. https://doi.org/10.1007/s00429-010-0256-y.

[61]	Ilzarbe, D., S. Lukito, C. Moessnang, et al. 2020. “Neural Correlates of Theory of Mind in Autism Spectrum Disorder, Attention-Deficit/Hyperactivity Disorder, and the Comorbid Condition.” Frontiers in Psychiatry 11: 544482. https://doi.org/10.3389/fpsyt.2020.544482.

[62]	Ishitobi, M., H. Kosaka, M. Omori, et al. 2011. “Differential Amygdala Response to Lower Face in Patients With Autistic Spectrum Disorders: An fMRI Study.” Research in Autism Spectrum Disorders 5, no. 2: 910–919. https://doi.org/10.1016/j.rasd.2010.10.005.

[63]	Jitsuishi, T., and A. Yamaguchi. 2021. “Posterior Precuneus Is Highly Connected to Medial Temporal Lobe Revealed by Tractography and White Matter Dissection.” Neuroscience 466: 173–185. https://doi.org/10.1016/j.neuroscience.2021.05.009.

[64]	Joseph, R. M., B. Keehn, C. Connolly, J. M. Wolfe, and T. S. Horowitz. 2009. “Why is Visual Search Superior in Autism Spectrum Disorder?” Developmental Science 12, no. 6: 1083–1096. https://doi.org/10.1111/j.1467-7687.2009.00855.x.

[65]	Kana, R. K., T. A. Keller, V. L. Cherkassky, N. J. Minshew, and M. A. Just. 2009. “Atypical Frontal-Posterior Synchronization of Theory of Mind Regions in Autism During Mental State Attribution.” Social Neuroscience 4, no. 2: 135–152. https://doi.org/10.1080/17470910802198510.

[66]	Kana, R. K., L. E. Libero, C. P. Hu, H. D. Deshpande, and J. S. Colburn. 2014. “Functional Brain Networks and White Matter Underlying Theory-Of-Mind in Autism.” Social Cognitive and Affective Neuroscience 9, no. 1: 98–105. https://doi.org/10.1093/scan/nss106.

[67]	Kana, R. K., J. O. Maximo, D. L. Williams, et al. 2015. “Aberrant Functioning of the Theory-Of-Mind Network in Children and Adolescents With Autism.” Molecular Autism 6: 59. https://doi.org/10.1186/s13229-015-0052-x.

[68]	Keehn, B., L. Brenner, E. Palmer, A. J. Lincoln, and R. A. Muller. 2008. “Functional Brain Organization for Visual Search in ASD.” Journal of the International Neuropsychological Society 14, no. 6: 990–1003. https://doi.org/10.1017/S1355617708081356.

[69]	Khan, A. J., A. Nair, C. L. Keown, M. C. Datko, A. J. Lincoln, and R. A. Muller. 2015. “Cerebro-Cerebellar Resting-State Functional Connectivity in Children and Adolescents With Autism Spectrum Disorder.” Biological Psychiatry 78, no. 9: 625–634. https://doi.org/10.1016/j.biopsych.2015.03.024.

[70]	Kim, E., S. Kyeong, K. A. Cheon, et al. 2016. “Neural Responses to Affective and Cognitive Theory of Mind in Children and Adolescents With Autism Spectrum Disorder.” Neuroscience Letters 621: 117–125. https://doi.org/10.1016/j.neulet.2016.04.026.

[71]	Klin, A., D. J. Lin, P. Gorrindo, G. Ramsay, and W. Jones. 2009. “Two-Year-Olds With Autism Orient to Non-Social Contingencies Rather Than Biological Motion.” Nature 459, no. 7244: 257. https://doi.org/10.1038/nature07868.

[72]	Koldewyn, K., D. Whitney, and S. M. Rivera. 2011. “Neural Correlates of Coherent and Biological Motion Perception in Autism.” Developmental Science 14, no. 5: 1075–1088. https://doi.org/10.1111/j.1467-7687.2011.01058.x.

[73]	Koshino, H., P. A. Carpenter, N. J. Minshew, V. L. Cherkassky, T. A. Keller, and M. A. Just. 2005. “Functional Connectivity in an fMRI Working Memory Task in High-Functioning Autism.” NeuroImage 24, no. 3: 810–821. https://doi.org/10.1016/j.neuroimage.2004.09.028.

[74]	Krajbich, I., R. Adolphs, D. Tranel, N. L. Denburg, and C. F. Camerer. 2009. “Economic Games Quantify Diminished Sense of Guilt in Patients With Damage to the Prefrontal Cortex.” Journal of Neuroscience 29, no. 7: 2188–2192. https://doi.org/10.1523/JNEUROSCI.5086-08.2009.

[75]	Kringelbach, M. L., and E. T. Rolls. 2004. “The Functional Neuroanatomy of the Human Orbitofrontal Cortex: Evidence From Neuroimaging and Neuropsychology.” Progress in Neurobiology 72, no. 5: 341–372. https://doi.org/10.1016/j.pneurobio.2004.03.006.

[76]	Kuusikko, S., H. Haapsamo, E. Jansson-Verkasalo, et al. 2009. “Emotion Recognition in Children and Adolescents With Autism Spectrum Disorders.” Journal of Autism and Developmental Disorders 39, no. 6: 938–945. https://doi.org/10.1007/s10803-009-0700-0.

[77]	Lacadie, C. M., R. K. Fulbright, N. Rajeevan, R. T. Constable, and X. Papademetris. 2008. “More Accurate Talairach Coordinates for Neuroimaging Using Non-Linear Registration.” NeuroImage 42, no. 2: 717–725. https://doi.org/10.1016/j.neuroimage.2008.04.240.

[78]	Lan, Y., H. Yuan, X. Ma, et al. 2024. “Resting-State Functional Connectivity of the Occipital Cortex in Different Subtypes of Parkinson's Disease.” CNS Neuroscience & Therapeutics 30, no. 8: e14915. https://doi.org/10.1111/cns.14915.

[79]	Lee, M., P. Sehatpour, M. J. Hoptman, et al. 2017. “Neural Mechanisms of Mismatch Negativity Dysfunction in Schizophrenia.” Molecular Psychiatry 22, no. 11: 1585–1593. https://doi.org/10.1038/mp.2017.3.

[80]	Lee, P. S., J. Foss-Feig, J. G. Henderson, et al. 2007. “Atypical Neural Substrates of Embedded Figures Task Performance in Children With Autism Spectrum Disorder.” NeuroImage 38, no. 1: 184–193. https://doi.org/10.1016/j.neuroimage.2007.07.013.

[81]	Li, Q., W. Zhao, L. Palaniyappan, and S. Guo. 2023. “Atypical Hemispheric Lateralization of Brain Function and Structure in Autism: A Comprehensive Meta-Analysis Study.” Psychological Medicine 53, no. 14: 6702–6713. https://doi.org/10.1017/S0033291723000181.

[82]	Libero, L. E., J. O. Maximo, H. D. Deshpande, L. G. Klinger, M. R. Klinger, and R. K. Kana. 2014. “The Role of Mirroring and Mentalizing Networks in Mediating Action Intentions in Autism.” Molecular Autism 5, no. 1: 50. https://doi.org/10.1186/2040-2392-5-50.

[83]	Luna, B., N. J. Minshew, K. E. Garver, et al. 2002. “Neocortical System Abnormalities in Autism: An fMRI Study of Spatial Working Memory.” Neurology 59, no. 6: 834–840. https://doi.org/10.1212/wnl.59.6.834.

[84]	Manjaly, Z. M., N. Bruning, S. Neufang, et al. 2007. “Neurophysiological Correlates of Relatively Enhanced Local Visual Search in Autistic Adolescents.” NeuroImage 35, no. 1: 283–291. https://doi.org/10.1016/j.neuroimage.2006.11.036.

[85]	Mišić, B., and O. Sporns. 2016. “From Regions to Connections and Networks: New Bridges Between Brain and Behavior.” Current Opinion in Neurobiology 40: 1–7.

[86]	Mitchell, J. P. 2008. “Activity in Right Temporo-Parietal Junction is Not Selective for Theory-Of-Mind.” Cerebral Cortex 18, no. 2: 262–271. https://doi.org/10.1093/cercor/bhm051.

[87]	Molenberghs, P., H. Johnson, J. D. Henry, and J. B. Mattingley. 2016. “Understanding the Minds of Others: A Neuroimaging Meta-Analysis.” Neuroscience and Biobehavioral Reviews 65: 276–291. https://doi.org/10.1016/j.neubiorev.2016.03.020.

[88]	Naqvi, N. H., D. Rudrauf, H. Damasio, and A. Bechara. 2007. “Damage to the Insula Disrupts Addiction to Cigarette Smoking.” Science 315, no. 5811: 531–534. https://doi.org/10.1126/science.1135926.

[89]	Ninomiya, T., A. Noritake, M. Ullsperger, and M. Isoda. 2018. “Performance Monitoring in the Medial Frontal Cortex and Related Neural Networks: From Monitoring Self Actions to Understanding Others' Actions.” Neuroscience Research 137: 1–10. https://doi.org/10.1016/j.neures.2018.04.004.

[90]	O'Riordan, M. A., K. C. Plaisted, J. Driver, and S. Baron-Cohen. 2001. “Superior Visual Search in Autism.” Journal of Experimental Psychology. Human Perception and Performance 27, no. 3: 719–730. https://doi.org/10.1037//0096-1523.27.3.719.

[91]	Page, M. J., J. E. McKenzie, P. M. Bossuyt, et al. 2021. “The PRISMA 2020 Statement: an Updated Guideline for Reporting Systematic Reviews.” BMJ: n71. https://doi.org/10.1136/bmj.n71.

[92]	Pelphrey, K. A., J. P. Morris, and G. McCarthy. 2005. “Neural Basis of Eye Gaze Processing Deficits in Autism.” Brain 128, no. 5: 1038–1048. https://doi.org/10.1093/brain/awh404.

[93]	Peng, S., P. Xu, Y. Jiang, and G. Gong. 2022. “Activation Network Mapping for Integration of Heterogeneous fMRI Findings.” Nature Human Behaviour 6, no. 10: 1417–1429. https://doi.org/10.1038/s41562-022-01371-1.

[94]	Preckel, K., P. Kanske, and T. Singer. 2018. “On the Interaction of Social Affect and Cognition: Empathy, Compassion and Theory of Mind.” Current Opinion in Behavioral Sciences 19: 1–6. https://doi.org/10.1016/j.cobeha.2017.07.010.

[95]	Rasga, C., A. C. Quelhas, and R. M. J. Byrne. 2017. “How Children With Autism Reason About Other's Intentions: False-Belief and Counterfactual Inferences.” Journal of Autism and Developmental Disorders 47, no. 6: 1806–1817. https://doi.org/10.1007/s10803-017-3107-3.

[96]	Redcay, E., D. Dodell-Feder, P. L. Mavros, et al. 2013. “Atypical Brain Activation Patterns During a Face-To-Face Joint Attention Game in Adults With Autism Spectrum Disorder.” Human Brain Mapping 34, no. 10: 2511–2523. https://doi.org/10.1002/hbm.22086.

[97]	Rosenblau, G., D. Kliemann, B. Lemme, H. Walter, H. R. Heekeren, and I. Dziobek. 2016. “The Role of the Amygdala in Naturalistic Mentalising in Typical Development and in Autism Spectrum Disorder.” British Journal of Psychiatry 208, no. 6: 556–564. https://doi.org/10.1192/bjp.bp.114.159269.

[98]	Rudie, J. D., Z. Shehzad, L. M. Hernandez, et al. 2012. “Reduced Functional Integration and Segregation of Distributed Neural Systems Underlying Social and Emotional Information Processing in Autism Spectrum Disorders.” Cerebral Cortex 22, no. 5: 1025–1037. https://doi.org/10.1093/cercor/bhr171.

[99]	Santiesteban, I., S. White, J. Cook, S. J. Gilbert, C. Heyes, and G. Bird. 2012. “Training Social Cognition: From Imitation to Theory of Mind.” Cognition 122, no. 2: 228–235. https://doi.org/10.1016/j.cognition.2011.11.004.

[100]

Saxe, R. 2006. “Uniquely Human Social Cognition.” Current Opinion in Neurobiology 16, no. 2: 235–239. https://doi.org/10.1016/j.conb.2006.03.001.

[101]

Saxe, R., and N. Kanwisher. 2003. “People Thinking About Thinking People: The Role of the Temporo-Parietal Junction in “Theory of Mind”.” NeuroImage 19, no. 4: 1835–1842. https://doi.org/10.1016/s1053-8119(03)00230-1.

[102]

Schaafsma, S. M., D. W. Pfaff, R. P. Spunt, and R. Adolphs. 2015. “Deconstructing and Reconstructing Theory of Mind.” Trends in Cognitive Sciences 19, no. 2: 65–72. https://doi.org/10.1016/j.tics.2014.11.007.

[103]

Schaefer, A., R. Kong, E. M. Gordon, et al. 2018. “Local-Global Parcellation of the Human Cerebral Cortex From Intrinsic Functional Connectivity MRI.” Cerebral Cortex 28, no. 9: 3095–3114. https://doi.org/10.1093/cercor/bhx179.

[104]

Schneider, K., C. Regenbogen, K. D. Pauly, et al. 2013. “Evidence for Gender-Specific Endophenotypes in High-Functioning Autism Spectrum Disorder During Empathy.” Autism Research 6, no. 6: 506–521. https://doi.org/10.1002/aur.1310.

[105]

Schurz, M., J. Radua, M. Aichhorn, F. Richlan, and J. Perner. 2014. “Fractionating Theory of Mind: A Meta-Analysis of Functional Brain Imaging Studies.” Neuroscience and Biobehavioral Reviews 42: 9–34. https://doi.org/10.1016/j.neubiorev.2014.01.009.

[106]

Schurz, M., J. Radua, M. G. Tholen, et al. 2021. “Toward a Hierarchical Model of Social Cognition: A Neuroimaging Meta-Analysis and Integrative Review of Empathy and Theory of Mind.” Psychological Bulletin 147, no. 3: 293–327. https://doi.org/10.1037/bul0000303.

[107]

Shah, A., and U. Frith. 1983. “An Islet of Ability in Autistic Children: A Research Note.” Journal of Child Psychology and Psychiatry 24, no. 4: 613–620. https://doi.org/10.1111/j.1469-7610.1983.tb00137.x.

[108]

Shamay-Tsoory, S. G., H. Harari, J. Aharon-Peretz, and Y. Levkovitz. 2010. “The Role of the Orbitofrontal Cortex in Affective Theory of Mind Deficits in Criminal Offenders With Psychopathic Tendencies.” Cortex 46, no. 5: 668–677. https://doi.org/10.1016/j.cortex.2009.04.008.

[109]

Shamay-Tsoory, S. G., R. Tomer, B. D. Berger, D. Goldsher, and J. Aharon-Peretz. 2005. “Impaired “Affective Theory of Mind” Is Associated With Right Ventromedial Prefrontal Damage.” Cognitive and Behavioral Neurology 18, no. 1: 55–67. https://doi.org/10.1097/01.wnn.0000152228.90129.99.

[110]

Sherman, S. M., and R. W. Guillery. 2002. “The Role of the Thalamus in the Flow of Information to the Cortex.” Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 357, no. 1428: 1695–1708. https://doi.org/10.1098/rstb.2002.1161.

[111]

Shic, F., S. Macari, and K. Chawarska. 2014. “Speech Disturbs Face Scanning in 6-Month-Old Infants Who Develop Autism Spectrum Disorder.” Biological Psychiatry 75, no. 3: 231–237. https://doi.org/10.1016/j.biopsych.2013.07.009.

[112]

Simpson, E. H., C. Kellendonk, and E. Kandel. 2010. “A Possible Role for the Striatum in the Pathogenesis of the Cognitive Symptoms of Schizophrenia.” Neuron 65, no. 5: 585–596. https://doi.org/10.1016/j.neuron.2010.02.014.

[113]

Sodian, B., and S. Kristen-Antonow. 2015. “Declarative Joint Attention as a Foundation of Theory of Mind.” Developmental Psychology 51, no. 9: 1190–1200. https://doi.org/10.1037/dev0000039.

[114]

Sommer, M., K. Döhnel, I. Jarvers, et al. 2018. “False Belief Reasoning in Adults With and Without Autistic Spectrum Disorder: Similarities and Differences.” Frontiers in Psychology 9: 183. https://doi.org/10.3389/fpsyg.2018.00183.

[115]

Stacy, S., S. Gong, A. Parab, M. Zhao, K. Jiang, and T. Gao. 2024. “A Bayesian Theory of Mind Approach to Modeling Cooperation and Communication.” Wiley Interdisciplinary Reviews: Computational Statistics 16, no. 1: e1631. https://doi.org/10.1002/wics.1631.

[116]

Stantic, M., E. Ichijo, C. Catmur, and G. Bird. 2022. “Face Memory and Face Perception in Autism.” Autism 26, no. 1: 276–280. https://doi.org/10.1177/13623613211027685.

[117]

Sterzer, P., and A. Kleinschmidt. 2010. “Anterior Insula Activations in Perceptual Paradigms: Often Observed but Barely Understood.” Brain Structure & Function 214, no. 5–6: 611–622. https://doi.org/10.1007/s00429-010-0252-2.

[118]

Stoodley, C. J. 2012. “The Cerebellum and Cognition: Evidence From Functional Imaging Studies.” Cerebellum 11, no. 2: 352–365. https://doi.org/10.1007/s12311-011-0260-7.

[119]

Stroth, S., L. Paye, I. Kamp-Becker, et al. 2019. “Empathy in Females With Autism Spectrum Disorder.” Frontiers in Psychiatry 10: 428. https://doi.org/10.3389/fpsyt.2019.00428.

[120]

Thompson, J., and R. Parasuraman. 2012. “Attention, Biological Motion, and Action Recognition.” NeuroImage 59, no. 1: 4–13. https://doi.org/10.1016/j.neuroimage.2011.05.044.

[121]

Tomasi, D., and N. D. Volkow. 2019. “Reduced Local and Increased Long-Range Functional Connectivity of the Thalamus in Autism Spectrum Disorder.” Cerebral Cortex 29, no. 2: 573–585. https://doi.org/10.1093/cercor/bhx340.

[122]

Urbain, C. M., E. W. Pang, and M. J. Taylor. 2015. “Atypical Spatiotemporal Signatures of Working Memory Brain Processes in Autism.” Translational Psychiatry 5, no. 8: e617. https://doi.org/10.1038/tp.2015.107.

[123]

Vacas, J., A. Antoli, A. Sanchez-Raya, C. Perez-Duenas, and F. Cuadrado. 2021. “Visual Preference for Social vs. Non-Social Images in Young Children With Autism Spectrum Disorders. An Eye Tracking Study.” PLoS One 16, no. 6: e0252795. https://doi.org/10.1371/journal.pone.0252795.

[124]

Van Overwalle, F. 2009. “Social Cognition and the Brain: A Meta-Analysis.” Human Brain Mapping 30, no. 3: 829–858. https://doi.org/10.1002/hbm.20547.

[125]

Vogan, V. M., K. E. Francis, B. R. Morgan, M. L. Smith, and M. J. Taylor. 2018. “Load Matters: Neural Correlates of Verbal Working Memory in Children With Autism Spectrum Disorder.” Journal of Neurodevelopmental Disorders 10, no. 1: 19. https://doi.org/10.1186/s11689-018-9236-y.

[126]

Votinov, M., A. Myznikov, M. Zheltyakova, et al. 2021. “The Interaction Between Caudate Nucleus and Regions Within the Theory of Mind Network as a Neural Basis for Social Intelligence.” Frontiers in Neural Circuits 15: 727960. https://doi.org/10.3389/fncir.2021.727960.

[127]

Vucurovic, K., S. Caillies, and A. Kaladjian. 2020. “Neural Correlates of Theory of Mind and Empathy in Schizophrenia: An Activation Likelihood Estimation Meta-Analysis.” Journal of Psychiatric Research 120: 163–174. https://doi.org/10.1016/j.jpsychires.2019.10.018.

[128]

Wang, Y., Y. B. Zhang, L. L. Liu, et al. 2017. “A Meta-Analysis of Working Memory Impairments in Autism Spectrum Disorders.” Neuropsychology Review 27, no. 1: 46–61. https://doi.org/10.1007/s11065-016-9336-y.

[129]

Wang, Z., L. Fei, Y. Sun, J. Li, F. Wang, and Z. Lu. 2019. “The Role of the Precuneus and Posterior Cingulate Cortex in the Neural Routes to Action.” Computer Assisted Surgery 24, no. sup1: 113–120. https://doi.org/10.1080/24699322.2018.1557903.

[130]

Weigelt, S., K. Koldewyn, and N. Kanwisher. 2012. “Face Identity Recognition in Autism Spectrum Disorders: A Review of Behavioral Studies.” Neuroscience and Biobehavioral Reviews 36, no. 3: 1060–1084. https://doi.org/10.1016/j.neubiorev.2011.12.008.

[131]

Wellman, H. M., S. Baron-Cohen, R. Caswell, et al. 2002. “Thought-Bubbles Help Children With Autism Acquire an Alternative to a Theory of Mind.” Autism 6, no. 4: 343–363. https://doi.org/10.1177/1362361302006004003.

[132]

Williams, D., and F. Happe. 2010. “Representing Intentions in Self and Other: Studies of Autism and Typical Development.” Developmental Science 13, no. 2: 307–319. https://doi.org/10.1111/j.1467-7687.2009.00885.x.

[133]

Williams, D. L. 2011. “Making Connections Between the Brain and Behavior Invited Commentary on “Disrupted Cortical Connectivity Theory as an Explanatory Model for Autism Spectrum Disorders” by RK Kana, LE Libero, and MS Moore.” Physics of Life Reviews 8, no. 4: 438–439. https://doi.org/10.1016/j.plrev.2011.10.021.

[134]

Williams, J. H., G. D. Waiter, O. Perra, D. I. Perrett, and A. Whiten. 2005. “An fMRI Study of Joint Attention Experience.” NeuroImage 25, no. 1: 133–140. https://doi.org/10.1016/j.neuroimage.2004.10.047.

[135]

Yang, D. Y., G. Rosenblau, C. Keifer, and K. A. Pelphrey. 2015. “An Integrative Neural Model of Social Perception, Action Observation, and Theory of Mind.” Neuroscience and Biobehavioral Reviews 51: 263–275. https://doi.org/10.1016/j.neubiorev.2015.01.020.

[136]

Yang, Y., Y. Tian, J. Fang, H. Lu, K. Wei, and L. Yi. 2017. “Trust and Deception in Children With Autism Spectrum Disorders: A Social Learning Perspective.” Journal of Autism and Developmental Disorders 47, no. 3: 615–625. https://doi.org/10.1007/s10803-016-2983-2.

[137]

Yeo, B. T., F. M. Krienen, J. Sepulcre, et al. 2011. “The Organization of the Human Cerebral Cortex Estimated by Intrinsic Functional Connectivity.” Journal of Neurophysiology 106, no. 3: 1125–1165. https://doi.org/10.1152/jn.00338.2011.

[138]

Yuk, V., C. Urbain, E. W. Pang, E. Anagnostou, D. Buchsbaum, and M. J. Taylor. 2018. “Do You Know What I'm Thinking? Temporal and Spatial Brain Activity During a Theory-Of-Mind Task in Children With Autism.” Developmental Cognitive Neuroscience 34: 139–147. https://doi.org/10.1016/j.dcn.2018.08.001.

[139]

Zhao, H. C., R. Lv, G. Y. Zhang, et al. 2021. “Alterations of Prefrontal-Posterior Information Processing Patterns in Autism Spectrum Disorders.” Frontiers in Neuroscience 15: 768219. https://doi.org/10.3389/fnins.2021.768219.