Additive manufacturing in nano drug delivery systems

Abstract

The adoption of innovative mixing and fabrication technologies in the pharmaceutical industry has inspired research on nano-drugs and expanded the scope of study in the field. Researchers' interest in the recently discovered drug delivery nanoparticles has increased significantly. This interest is especially seen in the specific preparation of nanoparticles as drug carriers through the use of three-dimensional (3D) printing, a modern additive manufacturing (AM) technology. The benefits of 3D printing, especially at the nanoscale, make it an innovative technology that could revolutionize the pharmaceutical and regenerative medicine industries. The laborious creation of intricate structures made possible by nanoscale 3D printing brings up the possibility of developing nanomedicine and producing functioning tissues and organs. The uses of AM in nano drug delivery systems (NDDS) are highlighted in this study, with a focus on how it can improve drug release kinetics, enhance therapeutic efficacy, and minimize side effects. A new era of personalized medicine has begun with the development of patient-specific formulations made possible by the customization capabilities of 3D printing. This review discusses the various uses of AM in NDDS while addressing issues including scalability, biocompatibility, and regulatory concerns. This review highlights the developing integration between AM and nanotechnology in medicine delivery and discusses ongoing research activities and possible solutions. As this innovative technology develops further, it has the potential to completely change the pharmaceutical development field by providing fresh approaches to the complex problems of contemporary healthcare and advancing the ideas behind drug delivery.

Keywords

3D printing / Nano drug / Delivery / Hydrogels / Nanoparticles

Credit authorship contribution statement

Md. Habibur Rahman completed the writing task; Nilufar Yasmin Liza completed the literature search and screening; Md. Abu Shyeed wrote and reviewed the manuscript; Dipika Ramdas Kalambhe checked and reviewed the writing quality of the article; Dilwar Hossain Noor oversaw resources and reviewing; Khan Rajib Hossain determined the direction and content composition of the article and checked and reviewed the writing quality of the article. All authors have reviewed and approved the final manuscript, attesting to its accuracy and their collective commitment to the review.

Data availability

Not applicable.

Ethics approval

Not applicable.

Funding information

No agency funding was used in the drafting of this manuscript.

Declaration of interest

The authors declared that they have no involvement of affiliations with any financial institution or entity with any financial or non-financial interest in the contents discussed in this manuscript. The authors also do not have any conflict of interest.

Acknowledgments

With the extraordinary assistance of my mentor, Khan Rajib Hossain, this review that underpinned it was feasible. I want to thank the following co-authors for their knowledge and assistance in all facets of our work and for their aid in authoring the manuscript. The authors appreciate the efforts of Md. Abu Shyeed and Nilufar Yasmin Liza for checking and reviewing the writing quality of the article. We should thank Dilwar Hossain Noor and Dipika Ramdas Kalambhe for their advice and reviewing on preparing the manuscript.

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