Genetic correlations and clinical value of increased renal echogenicity in fetuses identified by prenatal ultrasonography

Abstract

To explore the clinical value of prenatal ultrasound suggesting enhanced fetal renal echo, compare the genetic results and pregnancy outcomes, and provide reference for clinical consultation and prognostic evaluation. A total of 163 cases with enhanced fetal renal echo detected by ultrasound were collected. The ultrasound images and basic maternal data were analyzed, the genetic diagnosis results were compared, and the pregnancy outcomes were followed up. Among the 163 cases, 42 cases (25.77%) of genetic abnormalities were detected, including 24 cases (57.14%) of chromosomal abnormalities, among which 17q microdeletion accounted for the highest proportion. The differences in the detection rate of genetic abnormalities and the incidence of adverse pregnancy outcomes between the advanced age group and the non-advanced age group were statistically significant (p < .05). Enhanced fetal renal echo is closely related to genetic abnormalities, especially 17q abnormalities. When the pregnant woman is of advanced age or the fetus is complicated with other ultrasound abnormalities, the risk of genetic abnormalities increases, requiring focused screening and intervention.

Keywords

enhanced fetal renal echo / genetic diagnosis / prenatal ultrasound

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RIGHTS & PERMISSIONS

2026 The Author(s). Precision Medical Sciences published by John Wiley & Sons Australia, Ltd on behalf of Nanjing Medical University Affiliated Cancer Hospital & Jiangsu Cancer Hospital.