Fiber-Optic Raman Spectrum Sensor for Fast Diagnosis of Esophageal Cancer

Jianhua Dai; Xiu He; Zhuoyue Li; Kang Li; Tingting Yang; Zengling Ran; Lijian Yin; Yao Chen; Xiang Zou; Dianchun Fang; Guiyong Peng

doi:10.1007/s13320-018-0516-7

Photonic Sensors ›› 2018, Vol. 9 ›› Issue (1) : 53 -59. DOI: 10.1007/s13320-018-0516-7

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Fiber-Optic Raman Spectrum Sensor for Fast Diagnosis of Esophageal Cancer

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Abstract

A fiber-optic Raman spectrum sensor system is used for the fast diagnosis of esophageal cancer during clinical endoscopic examination. The system contains a 785 nm exciting laser, a Raman fiber-optic probe with 7 large core fibers and a focus lens, and a highly sensitive spectrum meter. The Raman spectrum of the tissue could be obtained within 1 second by using such a system. A signal baseline removal and denoising technology is used to improve the signal quality. A novel signal feature extraction method for differentiating the normal and esophageal cancer tissues is proposed, based on the differences in half-height width (HHW) in 1200 cm^‒1 to 1400 cm^‒1 frequency band and the ratios of the spectral integral energy between 1600 cm^‒1 − 1700 cm^‒1 and 1500 cm^‒1 − 1600 cm^‒1 band. It shows a high specificity and effectivity for the diagnosis of esophageal cancer.

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Fiber-optic / Raman spectrum / esophageal cancer

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Jianhua Dai, Xiu He, Zhuoyue Li, Kang Li, Tingting Yang, Zengling Ran, Lijian Yin, Yao Chen, Xiang Zou, Dianchun Fang, Guiyong Peng. Fiber-Optic Raman Spectrum Sensor for Fast Diagnosis of Esophageal Cancer. Photonic Sensors, 2018, 9(1): 53-59 DOI:10.1007/s13320-018-0516-7

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