Intracavernous and Intravenous Use of Contrast-Enhanced Ultrasound in Children: A Report of Five Cases and Review of the Literature

References

[1] A. Ntoulia, S. A. Anupindi, S. J. Back, et al., “Contrast-Enhanced Ultrasound: A Comprehensive Review of Safety in Children,” Pediatric Radiology 51, no. 12 (2021): 2161–2180.

[2] A. Ntoulia, E. Aguirre Pascual, S. J. Back, et al., “Contrast-Enhanced Voiding Urosonography, Part 1: Vesicoureteral Reflux Evaluation,” Pediatric Radiology 51, no. 12 (2021): 2351–2367.

[3] M. Mao, B. Xia, W. Chen, et al., “The Safety and Effectiveness of Intravenous Contrast-Enhanced Sonography in Chinese Children: A Single Center and Prospective Study in China,” Frontiers in Pharmacology 10 (2019): 1447.

[4] A. M. El-Ali, J. C. Davis, J. M. Cickelli, and J. H. Squires, “Contrast-Enhanced Ultrasound of Liver Lesions in Children,” Pediatric Radiology 49, no. 11 (2019): 1422–1432.

[5] M. Chen, M. Qiu, Y. Liu, W. Zhou, X. Xie, and L. Zhou, “Utility of the Pediatric Liver Contrast-Enhanced Ultrasound Criteria in Differentiating Malignant and Benign Multifocal Lesions,” Pediatric Radiology 53, no. 10 (2023): 2004–2012.

[6] G. Wang, X. Xie, H. Chen, et al., “Development of a Pediatric Liver CEUS Criterion to Classify Benign and Malignant Liver Lesions in Pediatric Patients: A Pilot Study,” European Radiology 31, no. 9 (2021): 6747–6757.

[7] A. Tong, K. Flemming, E. McInnes, S. Oliver, and J. Craig, “Enhancing Transparency in Reporting the Synthesis of Qualitative Research: ENTREQ,” BMC Medical Research Methodology 12, no. 1 (2012): 181.

[8] J. Niu, L. Sun, J. Zhang, et al., “Quantitative Analysis of CEUS in Differential Diagnosis of Benign and Malignant Ovarian Tumors” [in Chinese], Chinese Journal of Medical Imaging Technology 29, no. 6 (2013): 994–997, https://doi.org/10.13929/j.1003-3289.2013.06.044.

[9] R. Mao, Y.-J. Chen, B.-L. Chen, et al., “Intra-Cavitary Contrast-Enhanced Ultrasound: A Novel Radiation-Free Method for Detecting Abscess-Associated Penetrating Disease in Crohn’s Disease,” Journal of Crohn's and Colitis 13, no. 5 (2019): 593–599.

[10] E.-J. Xu, M. Zhang, K. Li, et al., “Intracavitary Contrast-Enhanced Ultrasound in the Management of Post-Surgical Gastrointestinal Fistulas,” Ultrasound in Medicine and Biology 44, no. 2 (2018): 502–507.

[11] Q.-Y. Shan, H. Jiang, S.-L. Chen, et al., “Postsurgical Management of Dilated Biliary Tract in Children: Ultrasound-Guided Percutaneous Transhepatic Cholangial Drainage and Subsequent Percutaneous Ultrasound Cholangiography,” American Journal of Roentgenology 214, no. 6 (2020): 1377–1383.

[12] L. Zhou, J. Xie, P. Gao, et al., “Percutaneous Ultrasound-Guided Cholecystocholangiography With Microbubbles Combined With Liver Biopsy for the Assessment of Suspected Biliary Atresia,” Pediatric Radiology 52, no. 6 (2022): 1075–1085.

[13] L.-Y. Zhou, S.-L. Chen, H.-D. Chen, et al., “Percutaneous US-Guided Cholecystocholangiography With Microbubbles for Assessment of Infants With US Findings Equivocal for Biliary Atresia and Gallbladder Longer Than 1.5 cm: A Pilot Study,” Radiology 286, no. 3 (2018): 1033–1039.

[14] Y.-J. Chen, R. Mao, X.-H. Xie, et al., “Intracavitary Contrast-Enhanced Ultrasonography to Detect Enterovesical Fistula in Crohn’s Disease,” Gastroenterology 150, no. 2 (2016): 315–317.

[15] D. Ključevšek, M. Riccabona, L.-S. Ording Müller, et al., “Intracavitary Contrast-Enhanced Ultrasonography in Children: Review With Procedural Recommendations and Clinical Applications From the European Society of Paediatric Radiology Abdominal Imaging Task Force,” Pediatric Radiology 50, no. 4 (2020): 596–606.

[16] C. Liu, Y. Li, Y. Zhu, and M. Lu, “The Value of IOTA Simple Rules Combined With CEUS Scoring System in the Diagnosis of Benign and Malignant Ovarian Masses and Its Correlation With MVD and VEGF: A Preliminary Study,” Journal of Ultrasound in Medicine 41, no. 12 (2022): 2983–2992.

[17] Z. Hu, S. Fan, X. Feng, et al., “Performance of Grayscale Combined With Contrast-Enhanced Ultrasound in Differentiating Benign and Malignant Pediatric Ovarian Masses,” European Radiology 35, no. 2 (2025): 828–836.

[18] J.-J. Ma and B. Zhang, “Diagnosis of an Actively Bleeding Brachial Artery Hematoma by Contrast-Enhanced Ultrasound: A Case Report,” World Journal of Clinical Cases 8, no. 17 (2020): 3835–3840.

[19] Y. He, Y. Yang, H. Zhang, X. Jia, and L. Du, “CEUS in Diagnosis and Follow-Up of Renal Hemorrhage Following Percutaneous Renal Biopsy” [in Chinese], Chinese Journal of Medical Imaging Technology 32, no. 3 (2016): 421–424, https://doi.org/10.13929/j.1003-3289.2016.03.026.

[20] D. Di Renzo, A. Persico, G. Lisi, et al., “Contrast-Enhanced Ultrasonography (CEUS) in the Follow-Up of Pediatric Abdominal Injuries: Value and Timing,” Journal of Ultrasound 23, no. 2 (2020): 151–155.

[21] M. Shunmugam and R. D. Goldman, “Testicular Torsion in Children,” Canadian Family Physician 67, no. 9 (2021): 669–671.

[22] M. Tenuta, F. Sesti, I. Bonaventura, et al., “Use of Contrast Enhanced Ultrasound in Testicular Diseases: A Comprehensive Review,” Andrology 9, no. 5 (2021): 1369–1382.

[23] C. Visalli, S. L. Vinci, S. Mondello, et al., “Microvascular Imaging Ultrasound (MicroV) and Power Doppler Vascularization Analysis in a Pediatric Population With Early Scrotal Pain Onset,” Japanese Journal of Radiology 40, no. 2 (2022): 192–201.

[24] L. Yi, C. Yong-Hui, L. Jin-Hui, and S. Li-Na, “Research on Contrast-Enhanced Ultrasound in Testicular Torsion After Reduction” [in Chinese], Journal of Chinese Practical Diagnosis and Therapy 28, no. 3 (2014): 261–262, https://doi.org/10.13507/j.issn.1674-3474.2014.03.022.

[25] W. Zhang, Z.-Q. Jin, M. Baikpour, et al., “Clinical Application of Ultrasound-Guided Percutaneous Microwave Ablation for Benign Breast Lesions: A Prospective Study,” BMC Cancer 19, no. 1 (2019): 345.

[26] M. Maybody, C. Comstock, S. Solomon, and A. Sag, “Percutaneous Image-Guided Ablation of Breast Tumors: An Overview,” Seminars in Interventional Radiology 31, no. 2 (2014): 193–202.

[27] W. Zhang, J.-M. Li, W. He, et al., “Ultrasound-Guided Percutaneous Microwave Ablation for Benign Breast Lesions: Evaluated by Contrast-Enhanced Ultrasound Combined With Magnetic Resonance Imaging,” Journal of Thoracic Disease 9, no. 11 (2017): 4767–4773.

[28] W. Zhou, R. Wang, X. Liu, et al., “Ultrasound-Guided Microwave Ablation: A Promising Tool in Management of Benign Breast Tumours,” International Journal of Hyperthermia 33, no. 3 (2017): 263–270.

[29] G. T. Yusuf, M. E. Sellars, A. Deganello, D. O. Cosgrove, and P. S. Sidhu, “Retrospective Analysis of the Safety and Cost Implications of Pediatric Contrast-Enhanced Ultrasound at a Single Center,” American Journal of Roentgenology 208, no. 2 (2017): 446–452.

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2026 The Author(s). Pediatric Discovery published by John Wiley & Sons Australia, Ltd on behalf of Children's Hospital of Chongqing Medical University.